Biotechnology Unzipped: Promises and Realities (1997)
Joseph Henry Press (JHP)
The views expressed in this book are solely those of the author(s) and do not necessarily reflect the views of the National Academies.
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How genes make proteins

It becomes difficult at this point in the story to avoid a textbook-like complexity, with descriptions of sections of genes that don't code for amino acids, sections that carry instructions for starting and stopping protein building, sections that overlap with each other, and so on. But although there's much more that can be said about the action of genes, you don't need these additional details in order to make sense of biotechnology. The table below summarizes the history outlined so far. Before bringing this account to an end, I'll just make one more point about the link between genes and proteins.

Steps on the road to biotechnology

Year

Event

1665

Robert Hooke describes and names cells

1675

Anton van Leeuwenhoek develops better microscopes and discovers microorganisms, bacteria, and sperm cells

1839

Matthias Schleiden and Theodore Schwann state their cell theory

1859

Charles Darwin publishes On The Origin of Species, establishing the theory of natural selection

1866

Gregor Mendel publishes Experiments With Plant Hybrids, outlining the principles of heredity

1869

Johann Miescher makes the first chemical analysis of nucleic acid

1902

Archibald Garrod speculates that genes consist of instructions for making proteins

1910

Thomas Hunt Morgan establishes that genes are located on chromosomes

1928

Fred Griffith finds that a "transforming principle" (genetic material) carries the trait of virulence from dead bacterial cells to live ones

1941

George Beadle and Edward Tatum establish that one gene makes one enzyme


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