Biotechnology Unzipped:Promises and Realities
(1997)
Joseph Henry Press (JHP)
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How genes make proteins
It becomes difficult at this point in the story to avoid a textbook-like complexity, with descriptions of sections of genes that don't code for amino acids, sections that carry instructions for starting and stopping protein building, sections that overlap with each other, and so on. But although there's much more that can be said about the action of genes, you don't need these additional details in order to make sense of biotechnology. The table below summarizes the history outlined so far. Before bringing this account to an end, I'll just make one more point about the link between genes and proteins.
Steps on the road to biotechnology
Year
Event
1665
Robert Hooke describes and names cells
1675
Anton van Leeuwenhoek develops better microscopes and discovers microorganisms, bacteria, and sperm cells
1839
Matthias Schleiden and Theodore Schwann state their cell theory
1859
Charles Darwin publishes On The Origin of Species, establishing the theory of natural selection
1866
Gregor Mendel publishes Experiments With Plant Hybrids, outlining the principles of heredity
1869
Johann Miescher makes the first chemical analysis of nucleic acid
1902
Archibald Garrod speculates that genes consist of instructions for making proteins
1910
Thomas Hunt Morgan establishes that genes are located on chromosomes
1928
Fred Griffith finds that a "transforming principle" (genetic material) carries the trait of virulence from dead bacterial cells to live ones
1941
George Beadle and Edward Tatum establish that one gene makes one enzyme