National Academies Press: OpenBook
Suggested Citation:"Front Matter." National Academy of Sciences. 1999. (NAS Colloquium) Proteolytic Processing and Physiological Regulation. Washington, DC: The National Academies Press. doi: 10.17226/9735.
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COLLOQUIUM ON PROTEOLYTIC PROCESSING AND PHYSIOLOGICAL REGULATION

NATIONAL ACADEMY OF SCIENCES
WASHINGTON, D.C. 1999

Suggested Citation:"Front Matter." National Academy of Sciences. 1999. (NAS Colloquium) Proteolytic Processing and Physiological Regulation. Washington, DC: The National Academies Press. doi: 10.17226/9735.
×

NATIONAL ACADEMY OF SCIENCES

Colloquium Series

In 1991, the National Academy of Sciences inaugurated a series of scientific colloquia, five or six of which are scheduled each year under the guidance of the NAS Council’s Committee on Scientific Programs. Each colloquium addresses a scientific topic of broad and topical interest, cutting across two or more of the traditional disciplines. Typically two days long, colloquia are international in scope and bring together leading scientists in the field. Papers from colloquia are published in the Proceedings of the National Academy of Sciences (PNAS).

Suggested Citation:"Front Matter." National Academy of Sciences. 1999. (NAS Colloquium) Proteolytic Processing and Physiological Regulation. Washington, DC: The National Academies Press. doi: 10.17226/9735.
×

Proteolytic Processing and Physiological Regulation

A Colloquium sponsored by the National Academy of Sciences

February 20–21, 1999

PROGRAM

Saturday, February 20, 1999

Hans Neurath, University of Washington

Welcome and introduction: Proteolytic enzymes, past and future

David Agard, University of California, San Francisco

Kinetic stability and folding of proteases: twin paradigms for protease pro regions

Michael James, University of Alberta

Structural basis and mechanism of zymogen activation

David Matthews, Agouron Pharmaceuticals, Inc.

Structure-assisted design of mechanism based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes

Christopher Walsh, Harvard University

Role of D, D-Peptidase in Vancomycin Resistance

Earl Davie, University of Washington

Introduction to Protease activated receptors

Shaun Coughlin, University of California, San Francisco

Thrombin signaling: Molecular mechanisms and roles in vivo

Vishva Dixit, Genentech, Inc.

Identification of components of the cell death pathway

Wolfram Bode, Max-Planck-Institute for Biochemistry

Structure of tryptase, a cage-like serine proteinase involved in asthma, allergic and inflammatory disorders

Philip Beachy, Johns Hopkins University

Hedgehog protein biogenesis and signaling

Marc Kirschner, Harvard University

The role of proteases in the regulation of cell cycle

Suggested Citation:"Front Matter." National Academy of Sciences. 1999. (NAS Colloquium) Proteolytic Processing and Physiological Regulation. Washington, DC: The National Academies Press. doi: 10.17226/9735.
×

Sunday, February 21, 1999

C.S.Craik, University of California, San Francisco

Introduction

Arthur Horwich, Yale University

Chaperone Rings in Protein Folding and Degradation

Robert Huber, Max-Planck-Institute for Biochemistry

Structure of the archaeal and yeast 20S proteasomes and of the eubacterial Analog HslV

Sukanto Sinha, Athena Neurosciences

Cellular mechanism of beta amyloid production and secretion

Michael Brown, University of Texas Southwestern Medical Center

A proteolytic system that controls cholesterol metabolism

Michael Brown

Introduction

Charles Craik, University of California, San Francisco

Reverse biochemistry-using protease inhibitors to dissect complex biochemical processes

Christine Debouck, Smith-Kline and Beecham Pharmaceuticals

From genomics to drugs—cathepsin K and osteoporosis

James McKerrow, University of California, San Francisco

Parasite proteases—windows on molecular evolution and targets for drug design

Joshua Boger, Vertex Pharmaceuticals

Recognizing a drug

Suggested Citation:"Front Matter." National Academy of Sciences. 1999. (NAS Colloquium) Proteolytic Processing and Physiological Regulation. Washington, DC: The National Academies Press. doi: 10.17226/9735.
×

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Table of Contents

Papers from a National Academy of Sciences Colloquium on Proteolytic Processing and Physiological Regulation

 

 

Proteolytic enzymes, past and future
Hans Neurath

 

10962–10963

 

 

Caspase activation: The induced-proximity model
Guy S.Salvesen and Vishva M.Dixit

 

10964–10967

 

 

Structural aspects of activation pathways of aspartic protease zymogens and viral 3C protease precursors
Amir R.Khan, Nina Khazanovich-Bernstein, Ernst M.Bergmann, and Michael N.G.James

 

10968–10975

 

 

The catalytic sites of 20S proteasomes and their role in subunit maturation: A mutational and crystallographic study
Michael Groll, Wolfgang Heinemeyer, Sibylle Jäger, Tobias Ullrich, Matthias Bochtler, Dieter H.Wolf, and Robert Huber

 

10976–10983

 

 

The structure of the human ßII-tryptase tetramer: Fo(u)r better or worse
Christian P.Sommerhoff, Wolfram Bode, Pedro J.B.Pereira, Milton T.Stubbs, Jörg Stürzebecher, Gerd P.Piechottka, Gabriele Matschiner, and Andreas Bergner

 

10984–10991

 

 

Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for Patched
Naoyuki Fuse, Tapan Maiti, Baolin Wang, Jeffery A.Porter, Traci M.Tanaka Hall, Daniel J.Leahy, and Philip A.Beachy

 

10992–10999

 

 

Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes
D.A.Matthews, P.S.Dragovich, S.E.Webber, S.A.Fuhrman, A.K.Patick, L.S.Zalman, T.F.Hendrickson, R.A.Love, T.J.Prins, J.T.Marakovits, R.Zhou, J.Tikhe, C.E.Ford, J.W.Meador, R.A.Ferre, E.L.Brown, S.L.Binford, M.A.Brothers, D.M.DeLisle, and S.T.Worland

 

11000–11007

 

 

Kinetic stability as a mechanism for protease longevity
Erin L.Cunningham, Sheila S.Jaswal, Julie L.Sohl, and David A.Agard

 

11008–11014

 

 

Cysteine protease inhibitors as chemotherapy: Lessons from a parasite target
Paul M.Selzer, Sabine Pingel, Ivy Hsieh, Bernhard Ugele, Victor J.Chan, Juan C.Engel, Matthew Bogyo, David G.Russell, Judy A.Sakanari, and James H.McKerrow

 

11015–11022

Suggested Citation:"Front Matter." National Academy of Sciences. 1999. (NAS Colloquium) Proteolytic Processing and Physiological Regulation. Washington, DC: The National Academies Press. doi: 10.17226/9735.
×
Suggested Citation:"Front Matter." National Academy of Sciences. 1999. (NAS Colloquium) Proteolytic Processing and Physiological Regulation. Washington, DC: The National Academies Press. doi: 10.17226/9735.
×

National Academy of Sciences Colloquia

Bound Reprints Available

In 1991, the National Academy of Sciences (NAS) inaugurated a series of scientific colloquia, several of which are held each year under the auspices of the NAS Coun cil Committee on Scientific Programs. These colloquia address scientific topics of broad and topical interest that cut across two or more traditional disciplines. Typically two days long, these colloquia are international in scope and bring together leading scientists in the field.

Papers presented at these colloquia are published in the Proceedings of the National Academy of Sciences (PNAS) and are available online (www.pnas.org). Because they have generated much interest, these papers are now available in the form of collected bound reprints, which may be ordered through the National Academy Press.

Currently available are:

Carbon Dioxide and Climate Change ($11)

Held November 13–15, 1995 (Irvine, CA)

Computational Biomolecular Science ($16)

Held September 12–13, 1997 (Irvine, CA)

Earthquake Prediction ($16)

Held February 10–11, 1995 (Irvine, CA)

Elliptic Curves and Modular Forms ($7)

Held March 15–17, 1996 (Washington, DC)

Genetic Engineering of Viruses and Viral Vectors ($21)

Held June 9–11, 1996 (Irvine, CA)

Genetics and the Origin of Species ($8)

Held January 31-February 1, 1997 (Irvine, CA)

Geology, Mineralogy, and Human Welfare ($11)

Held November 8–9, 1998 (Irvine, CA)

Neurobiology of Pain ($8)

Held December 11–13, 1998 (Irvine, CA)

Neuroimaging of Human Brain Function ($17)

Held May 29–31, 1997 (Irvine, CA)

Plants and Population: Is There Time? ($8)

Held December 5–6, 1998 (Irvine, CA)

Protecting Our Food Supply: The Value of

Plant Genome Initiatives ($13)

Held May 29–31, 1997 (Irvine, CA)

Science, Technology, and the Economy ($12)

Held November 20–22, 1995 (Irvine, CA)

The Age of the Universe, Dark Matter, and Structure Formation ($13)

Held March 21–23, 1997 (Irvine, CA)

Papers from future colloquia will be available for purchase after they appear in PNAS.

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In the U.S. and Canada please add $4.50 for the first reprint ordered and $0.95 for each additional reprint.

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To order, call toll-free 1–800–624–6242 or order online at www.nap.edu and receive a 20% discount.

Suggested Citation:"Front Matter." National Academy of Sciences. 1999. (NAS Colloquium) Proteolytic Processing and Physiological Regulation. Washington, DC: The National Academies Press. doi: 10.17226/9735.
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