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Toxicological Risks of Selected Flame-Retardant Chemicals (2000)
Commission on Life Sciences (CLS)

Page
237
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Toxicological Risks of Selected Flame-Retardant Chemicals

 

 

 

Interstitial inflammation and granulomatous inflammation

NOAEL: 0.9

LOAEL: 0.3

ND

ND

Watt 1983

Swine, Sinclair S-1, 3F

1.9, 5.0; 6 hr/d, 5 d/wk for 1 yr

0.3, 0.9

Minimal lung fibrosis

ND

ND

ND

Watt 1983

Rat, NS, 6–7

0.027, 0.082, 0.27; 24 hr/d for 21 d of gestation

0.027, 0.082, 0.27

Pre-implantation loss, fetal growth retardation, and pre-and post-implantation embryo death

NOAEL: 0.027

LOAEL: 0.082

ND

ND

Grin et al. 1987

BMC, benchmark concentration; F, female; HEC, human equivalent concentration; LOAEL, lowest-observed-adverse-effect level; M, male; ND, not determined; NOAEL, no-observed-adverse-effect level; RDDR, regional deposited dose ratio.

aAll inhalation exposures were whole body.

bConcentrations are adjusted for continuous exposure.

Page
237
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