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Toxicological Risks of Selected Flame-Retardant Chemicals
TABLE 4–1 Physical and Chemical Properties of HBCD
Property
Value
Reference
Chemical formula
C12H18Br6
CHEMID 1999
Chemical structure
CAS Registry #
25637–99–4 (mixed isomers)
CHEMID 1999
Molecular weight
641.7
Hatlelid 1999
Melting point
185–195°C
Hatlelid 1999
Vapor pressure
4.7×10−7 mm Hg
Stenzel and Nixon 1997
Density
2.24 g/cm3
Hatlelid 1999
Solubility in water
0.0034 mg/L
Stenzel and Markley 1997
Partition coefficient (Log Kow)
5.6
MacGregor and Nixon 1997
holstery seating in transportation, draperies, and wall coverings (FRCA 1998). HBCD is usually applied with antimony trioxide as a back coating in a mass ratio of 2:1 (i.e., about 6–15% HBCD and 4–10% antimony oxide by weight).
TOXICOKINETICS
No human data on the toxicokinetics of HBCD were located for any route. No toxicokinetic studies via the dermal or inhalation exposure routes were reported in experimental animals. However, in a report by Dean and Leong (1977), rats exposed dermally to a high dose of HBCD in saline experienced diarrhea and slight weight loss. This finding indicates that at least some absorption occurs via the dermal route.
In an unpublished study by Vesicol Chemical Corporation (1980), rats
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