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Marine Biotechnology in the Twenty-First Century: Problems, Promise, and Products (2002)
Ocean Studies Board (OSB)
Board on Life Sciences (BLS)

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54
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Marine Biotechnology in the Twenty-First Century: Problems, Promise, and Products

TABLE 4 A Sampling of Undeveloped Marine Compounds with Significant Indications of Efficacy

Marine Source

Compounds

Potential Uses

Reference

Sponge Trachycladus

Onnamide F atode worm

Antifungal, antinem

Vuong et al., 2001

Sponge Aka

Kynureninase inhibitors serotonin sulfate

Neuroprotectants for use in AIDS-dementia and stroke

Feng et al., 2000

Cyanobacterium Lyngbya

Hermitamides A, B

Anticancer

Tan et al., 2000

Sponge

Axisonitrile-3

AntiTuberculosis

König et al., 2000

Sea whip Pseudopterogorgia

Pseudopteroxazole

AntiTuberculosis

Rodriguez et al., 1999

Sponge Ircinia

Cheilanthane sesterterpenoids

Kinase inhibitors, multiple uses

Buchanan et al., 2001

Fungus Acremonium

Oxepinamide

Antiinflammatory

Belofsky et al., 2000

Fungus Acremonium

Fumiquinazoline

Antifungal

Belofsky et al., 2000

Natural source

Polycyclic acridines

Drug resistant lung cancer

Stanslas et al., 2000

Hydroid

Tridentatol A

Antioxidant inhibits LDL lipid peroxidation (superior to vitamin E)

Johnson et al., 1999

Ascidian

Lamellarin alpha 20-sulfate

AntiHIV virus

Reddy et al., 1999

Microorganisms

Cyclic depsipeptide Sansalvemide A

AntiPox virus (MCV)

Hwang et al., 1999

Natural source

Makaluvamines

Anticancer

Matsumoto et al., 1999

Crinoid

Gymnochrome D

Antidengue virus

Laille et al., 1998

Fungus Phoma

Phomactins

Antagonist of platelet activating factor

Sugano et al., 1996

Sponge Cymbastela

Diterpenes and others

Antimalarial

Wright et al., 1996

Xetospongia, Agelas

Xestospongine B, sceptrine, age

Cystic fibrosis, impotence, Alzheimer’s, cancer

Vassas et al., 1996

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