Complex Mixtures:

Methods for In Vivo Toxicity Testing

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Size: 240 pages, 6 x 9

Publication Year:1988

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HARDBACK ISBN-10: 0-309-03778-6 ISBN-13: 978-0-309-03778-5	$35.00	Add to Cart

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Committee on Methods for the In Vivo Toxicity Testing of Complex Mixtures, Board on Environmental Studies and Toxicology, National Research Council
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In the laboratory, testing the toxic effects for a single compound is a straightforward process. However, many common harmful substances occur naturally as mixtures and can interact to exhibit greater toxic effects as a mixture than the individual components exhibit ...
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Table of Contents
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Front Matter	i-xii
Executive Summary	1-4	(skim)
1. Introduction	5-9	(skim)
2. Concepts for Analyzing Human Exposure to Complex Chemical Mixtures	10-38	(skim)
3. Testing Strategies and Methods	39-64	(skim)
4. Sampling and Chemical Characterization	65-98	(skim)
5. Interpretation and Modeling of Toxicity-Test Results	99-124	(skim)
Appendix A: Origins of Complex Mixtures	125-132	(skim)
Appendix B: Case Studies Establishing Active Agents and/or Interactions in Complex Mixtures	133-167	(skim)
Appendix C: Case Studies on Strategies for Testing the Toxicity of Complex Mixtures	168-178	(skim)
Appendix D: Predicting the Joint Risk of a Misture in Terms of the Component Risks	179-184	(skim)
Appendix E: Cancer Models	185-201	(skim)
Appendix F: Developmental Toxicology	202-208	(skim)
Appendix G: Empirical Modeling of the Toxicity of Mixtures	209-220	(skim)
Index	221-228	(skim)

Description

In the laboratory, testing the toxic effects for a single compound is a straightforward process. However, many common harmful substances occur naturally as mixtures and can interact to exhibit greater toxic effects as a mixture than the individual components exhibit separately. Complex Mixtures addresses the problem of identifying and classifying complex mixtures, investigating the effect of exposure, and the research problems inherent in testing their toxicity to human beings. A complete series of case studies is presented, including one that examines the cofactors of alcohol consumption and cigarette smoke.

Complex Mixtures:

Methods for In Vivo Toxicity Testing

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