(Sackler NAS Colloquium) Self-Perpetuating Structural States in Biology, Disease, and Genetics

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Size: 136 pages, 8 1/2 x 11

Publication Year:2002

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Proceedings of the National Academy of Sciences
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Table of Contents
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Front Matter	i-vi
Self-perpetuating structural states in biology, disease, and genetics	1-1	(skim)
Transmission of prions	2-7	(skim)
Conservation of a portion of the S. cerevisiae Ure2p prion domain that interacts with the full-length protein	8-15	(skim)
Interactions among prions and prion “strains” in yeast	16-23	(skim)
Identification of benzothiazoles as potential polyglutamine aggregation inhibitors of Huntington	24-30	(skim)
Chaperoning brain degeneration	31-35	(skim)
Molecular chaperones as modulators of polyglutamine protein aggregation and toxicity	36-42	(skim)
Studies of the aggregation of mutant proteins in vitro provide insights into the genetics of amyloid diseases	43-50	(skim)
Sequence-dependent denaturation energetics: A major determinant in amyloid disease diversity	51-56	(skim)
The insulation of genes from external enhancers and silencing chromatin	57-61	(skim)
Histone H3 lysine 4 methylation is mediated by Set1 and promotes maintenance of active chromatin states in fission yeast	62-69	(skim)
Changes in the middle region of Sup35 profoundly alter the nature of epigenetic inheritance for the yeast prion [PSI+]	70-77	(skim)
Heritable chromatin structure: Mapping “memory” in histones H3 and H4	78-85	(skim)
Does heterochromatin protein 1 always follow code?	86-93	(skim)
Self-perpetuating epigenetic pili switches in bacteria	94-100	(skim)
Histone H3 variants specify modes of chromatin assembly	101-108	(skim)
Induction and maintenance of nonsymmetrical DNA methylation in Neurospora	109-114	(skim)
Locus-specific control of asymmetric and CpNpG methylation by the DRM and CMT3 methyltransferase genes	115-122	(skim)
RNA-directed DNA methylation in Arabidopsis	123-134	(skim)

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