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The report finds that the body can compensate for iodide deficiency, and that iodide uptake would likely have to be reduced by at least 75% for months or longer for adverse health effects, such as hypothryroidism, to occur. The report recommends using clinical studies of iodide uptake in humans as the basis for determining a reference dose rather than using studies of adverse health effects in rats that serve as EPA s basis. The report suggests that daily ingestion of 0.0007 milligrams of perchlorate per kilograms of body weight an amount more than 20 times the reference dose proposed by EPA should not threaten the health of even the most sensitive populations.
National Research Council. Health Implications of Perchlorate Ingestion . Washington, DC: The National Academies Press, 2005.
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