Beginning in the early 1980s, new technologies, began to permit evaluation of the expression of individual genes. Recent technological advances have expanded those evaluations to permit the simultaneous detection of the expression of tens of thousands of genes and to support holistic evaluations of the entire genome. The application of these technologies has enabled researchers to unravel complexities of cell biology and, in conjunction with toxicologic evaluations, the technologies are used to probe and gain insight into questions of toxicologic relevance. As a result, the use of the technologies has become increasingly important for scientists in academia, as well as for the regulatory and drug development process.
Table of Contents
|Summary of the Workshop||1-38|
|Attachment 1. Experimental Objectives of DNA Microarray Studies||39-48|
|Attachment 2. Comparison of Microarray Data from Multiple Labs and Platforms||49-57|
|Attachment 3. Statistical Analysis of Toxicogenomic Microarray Data||58-65|
|Attachment 4. Diagnostic Classifier – Gaining Confidence Through Validation||66-74|
|Appendix A: Workshop Planning Committee Biographical Information||75-78|
|Appendix B: Workshop Agenda||79-81|
|Appendix C: Federal Liaison Group for the NRC Committee on Emerging Issues and Data on Environmental Contaminants||82-84|
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