Christopher P. Howson, Cynthia J. Howe, and Harvey V. Fineberg, Editors;Committee to Review the Adverse Consequences of Pertussis and RubellaVaccines, Institute of Medicine
Parents have come to depend on vaccines to protect their children from a variety of diseases. Some evidence suggests, however, that vaccination against pertussis (whooping cough) and rubella (German measles) is, in a small number of cases, associated with increased risk of serious illness. This book examines the controversy over the evidence and offers a comprehensively documented assessment of the risk of illness following immunization with vaccines against pertussis and rubella. Based on extensive review of the evidence from epidemiologic studies, case histories, studies in animals, and other sources of information, the book examines:
The relation of pertussis vaccines to a number of serious adverse events, including encephalopathy and other central nervous system disorders, sudden infant death syndrome, autism, Guillain-Barre syndrome, learning disabilities, and Reye syndrome.
The relation of rubella vaccines to arthritis, various neuropathies, and thrombocytopenic purpura.
The volume, which includes a description of the committee's methods for evaluating evidence and directions for future research, will be important reading for public health officials, pediatricians, researchers, and concerned parents.
National Research Council. Adverse Effects of Pertussis and Rubella Vaccines . Washington, DC: The National Academies Press, 1991.