An Assessment of the NIH Women's Health Initiative

Authors

Susan Thaul and Dana Hotra, Editors; Committee to Review the NIH Women's Health Initiative, Institute of Medicine

Description

The National Institutes of Health Women's Health Initiative (WHI) is the largest research study ever funded by NIH ($625 million over 14 years) and is designed to test strategies to prevent cardiovascular disease, breast cancer, and osteoporotic fractures--leading causes of death, disability, and decreased quality of life for older women. Although the WHI has already begun, serious questions remain about its design, cost, and the likelihood that it can answer the questions it asks. This book evaluates whether the effort can be justified scientifically.

Front Matter i-xvi
Executive Summary 1-18
Introduction 19-24
Clinical Trial 25-76
Observational Study 77-80
Community Prevention Study 81-84
Concluding Remarks 85-90
References 91-94
Appendix A: Clinical Trial Exclusion Criteria 95-100
Appendix B: U.S. House of Representatives Appropriations COmmittee 101-102
Appendix C: Statement of Task 103-104
Appendix D: Documents Received by the Institute of Medicine from the National Institutes of Health 105-108
Appendix E: Meeting Participants June, July, and August 1993 109-112
Appendix F: Primary and Subsidiary Hypotheses of the Women's Health Initiative Clinical Trial 113-114
Appendix G: Women's Health Initiative Committees 115-116
Appendix H: NIH-Sponsored Women's Health Studies 117-122
Appendix I: NIH Cost and FTE Summary for Vanguard Clinical Centers 123-126
Appendix J: NIH Power Calculations 127-132
Appendix K: Women's Health Initiative Clinical Coordinating Center and Vanguard Clinical Centers Principal Investigators 133-134
Appendix L: Abbreviations and Acronyms 135-136
Appendix M: Committee and Staff Biographies 137-142

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An Assessment of the NIH Women's Health Initiative

(1993)

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An Assessment of the NIH Women's Health Initiative

(1993)

Overview

Authors

Description

Table of Contents

Front Matter i-xvi

Executive Summary 1-18

Introduction 19-24

Clinical Trial 25-76

Observational Study 77-80

Community Prevention Study 81-84

Concluding Remarks 85-90

References 91-94

Appendix A: Clinical Trial Exclusion Criteria 95-100

Appendix B: U.S. House of Representatives Appropriations COmmittee 101-102

Appendix C: Statement of Task 103-104

Appendix D: Documents Received by the Institute of Medicine from the National Institutes of Health 105-108

Appendix E: Meeting Participants June, July, and August 1993 109-112

Appendix F: Primary and Subsidiary Hypotheses of the Women's Health Initiative Clinical Trial 113-114

Appendix G: Women's Health Initiative Committees 115-116

Appendix H: NIH-Sponsored Women's Health Studies 117-122

Appendix I: NIH Cost and FTE Summary for Vanguard Clinical Centers 123-126

Appendix J: NIH Power Calculations 127-132

Appendix K: Women's Health Initiative Clinical Coordinating Center and Vanguard Clinical Centers Principal Investigators 133-134

Appendix L: Abbreviations and Acronyms 135-136

Appendix M: Committee and Staff Biographies 137-142

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