Biologic Markers in Reproductive Toxicology

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Size: 420 pages, 7 x 10

Publication Year:1989

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PAPERBACK ISBN-10: 0-309-03979-7 ISBN-13: 978-0-309-03979-6	$32.95	Add to Cart

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Subcommittee on Reproductive and Neurodevelopmental Toxicology, Committee on Biologic Markers, Board on Environmental Studies and Toxicology, National Research Council
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Does exposure to environmental toxicants inhibit our ability to have healthy children who develop normally? Biologic markers--indicators that can tell us when environmental factors have caused a change at the cellular or biochemical level that might affect reproductive ability--are a ...
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Table of Contents
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Front Matter	i-xxiv
Executive Summary	1-14	(skim)
1. Report of the Oversight Committee	15-36	(skim)
I. Biologic Markers in Male Reproductive and Gametic Genetic Toxicology	37-38	(skim)
2. Introduction	39-42	(skim)
3. Clinical Evaluation of Male Infertility	43-46	(skim)
4. Biologic Markers of Testicular Function	47-62	(skim)
5. Biologic Markers of Epididymal Structure and Function	63-76	(skim)
6. Biologic Markers of Accessory Sex Organ Structure and Function	77-82	(skim)
7. Biologic Markers of Human Male Reproductive Health and Physiologic Damage	83-106	(skim)
8. Assessing Transmitted Mutations in Mice	107-118	(skim)
9. Markers for Measuring Germinal Genetic Toxicity and Heritable Mutations in People	119-140	(skim)
10. Conclusions and Recommendations	141-146	(skim)
II. Biologic Markers in Female Reproductive Toxicology	147-148	(skim)
11. Introduction	149-162	(skim)
12. Biologic Markers of Genetic Damage in Females	163-168	(skim)
13. Biologic Markers of Reproductive Development and Aging	169-178	(skim)
14. Biologic Markers of Nonconceptive Menstrual Cycles	179-186	(skim)
15. Developing Assays of Biologic Markers for Epidemiologic Studies: Experience with a Marker of Pregnancy and Early Loss	187-196	(skim)
16. Conclusions and Recommendations	197-202	(skim)
III. Biologic Markers of Toxicity during Pregnancy	203-204	(skim)
17. Introduction	205-210	(skim)
18. Molecular Biology: Developing DNA Markers of Genotoxic Effects	211-214	(skim)
19. Reproductive Immunology: Biologic Markers of Compromised Pregnancies	215-222	(skim)
20. Cell Biology: Identifying Biologic Markers Expressed during Early Pregnancy	223-240	(skim)
21. Physiologic Assessment of Fetal Compromise	241-246	(skim)
22. Biologic Markers of Exposure during Pregnancy: Pharmacokinetic Assessments	247-252	(skim)
23. Conclusions and Recommendations	253-262	(skim)
IV. Biologic Markers in Neurodevelopmental Toxicology	263-264	(skim)
24. Introduction	265-272	(skim)
25. Developmental Neurobiology of the Central Nervous System	273-280	(skim)
26. Morphologic, Neurochemical, and Behavioral Responses to Toxic Agents	281-288	(skim)
27. Methodologic Issues of Extrapolation from Animal Studies to Human Toxicant Exposure	289-296	(skim)
28. Lead as a Paradigm for the Study of Neurodevelopmental Toxicology	297-302	(skim)
29. Conclusions and Recommendations	303-310	(skim)
Appendix: Assessing the Validity of Biologic Markers: Alpha-Fetoprotein	311-318	(skim)
References	319-372	(skim)
Biographies	373-380	(skim)
Index	381-396	(skim)

Description

Does exposure to environmental toxicants inhibit our ability to have healthy children who develop normally? Biologic markers--indicators that can tell us when environmental factors have caused a change at the cellular or biochemical level that might affect reproductive ability--are a promising tool for research aimed at answering that important question. Biologic Markers in Reproductive Toxicology examines the potential of these markers in environmental health studies; clarifies definitions, underlying concepts, and possible applications; and shows the benefits to be gained from their use in reproductive and neurodevelopmental research.

Biologic Markers in Reproductive Toxicology

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