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Biologic Markers in Reproductive Toxicology

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Status: Available Now

Size: 420 pages, 7 x 10

Publication Year:1989


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ISBN-10: 0-309-03979-7
ISBN-13: 978-0-309-03979-6
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Authors:
Subcommittee on Reproductive and Neurodevelopmental Toxicology, Committee on Biologic Markers, Board on Environmental Studies and Toxicology, National Research Council
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Description:
Does exposure to environmental toxicants inhibit our ability to have healthy children who develop normally? Biologic markers--indicators that can tell us when environmental factors have caused a change at the cellular or biochemical level that might affect reproductive ability--are a ...
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Table of Contents
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Front Matter i-xxiv  
Executive Summary 1-14 (skim)
1. Report of the Oversight Committee 15-36 (skim)
I. Biologic Markers in Male Reproductive and Gametic Genetic Toxicology 37-38 (skim)
2. Introduction 39-42 (skim)
3. Clinical Evaluation of Male Infertility 43-46 (skim)
4. Biologic Markers of Testicular Function 47-62 (skim)
5. Biologic Markers of Epididymal Structure and Function 63-76 (skim)
6. Biologic Markers of Accessory Sex Organ Structure and Function 77-82 (skim)
7. Biologic Markers of Human Male Reproductive Health and Physiologic Damage 83-106 (skim)
8. Assessing Transmitted Mutations in Mice 107-118 (skim)
9. Markers for Measuring Germinal Genetic Toxicity and Heritable Mutations in People 119-140 (skim)
10. Conclusions and Recommendations 141-146 (skim)
II. Biologic Markers in Female Reproductive Toxicology 147-148 (skim)
11. Introduction 149-162 (skim)
12. Biologic Markers of Genetic Damage in Females 163-168 (skim)
13. Biologic Markers of Reproductive Development and Aging 169-178 (skim)
14. Biologic Markers of Nonconceptive Menstrual Cycles 179-186 (skim)
15. Developing Assays of Biologic Markers for Epidemiologic Studies: Experience with a Marker of Pregnancy and Early Loss 187-196 (skim)
16. Conclusions and Recommendations 197-202 (skim)
III. Biologic Markers of Toxicity during Pregnancy 203-204 (skim)
17. Introduction 205-210 (skim)
18. Molecular Biology: Developing DNA Markers of Genotoxic Effects 211-214 (skim)
19. Reproductive Immunology: Biologic Markers of Compromised Pregnancies 215-222 (skim)
20. Cell Biology: Identifying Biologic Markers Expressed during Early Pregnancy 223-240 (skim)
21. Physiologic Assessment of Fetal Compromise 241-246 (skim)
22. Biologic Markers of Exposure during Pregnancy: Pharmacokinetic Assessments 247-252 (skim)
23. Conclusions and Recommendations 253-262 (skim)
IV. Biologic Markers in Neurodevelopmental Toxicology 263-264 (skim)
24. Introduction 265-272 (skim)
25. Developmental Neurobiology of the Central Nervous System 273-280 (skim)
26. Morphologic, Neurochemical, and Behavioral Responses to Toxic Agents 281-288 (skim)
27. Methodologic Issues of Extrapolation from Animal Studies to Human Toxicant Exposure 289-296 (skim)
28. Lead as a Paradigm for the Study of Neurodevelopmental Toxicology 297-302 (skim)
29. Conclusions and Recommendations 303-310 (skim)
Appendix: Assessing the Validity of Biologic Markers: Alpha-Fetoprotein 311-318 (skim)
References 319-372 (skim)
Biographies 373-380 (skim)
Index 381-396 (skim)

Description

Does exposure to environmental toxicants inhibit our ability to have healthy children who develop normally? Biologic markers--indicators that can tell us when environmental factors have caused a change at the cellular or biochemical level that might affect reproductive ability--are a promising tool for research aimed at answering that important question. Biologic Markers in Reproductive Toxicology examines the potential of these markers in environmental health studies; clarifies definitions, underlying concepts, and possible applications; and shows the benefits to be gained from their use in reproductive and neurodevelopmental research.

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