Microbial Status and Genetic Evaluation of Mice and Rats: Proceedings of the 1999 US/Japan Conference
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Microbial Status and Genetic Evaluation of Mice and Rats:
Proceedings of the 1999 US/Japan Conference
(2000)
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Publication Info

166 pages | 6 x 9
Paperback
ISBN: 978-0-309-07357-8
Contents

Table of Contents

skim chapter
Front Matter i-xvi
Opening Remarks, Judith Vaitukaitis 1-3
Opening Remarks, Shin-Ichi Ota 4-5
Introductory Comments on Microbiologic Testing of Laboratory Mice and Rats: Uniformity of Results 6-6
Development of a Performance Assessment Program for Research Animal Diagnostic Laboratories and Defining Microbiologic Testing Standards 7-10
Standardization of Rodent Health Surveillance: Regulation Versus Competition 11-15
Factors Causing Difficulties in Uniformity of Results Among Testing Facilities in Microbiologic Monitoring of Laboratory Animals 16-20
Necessity of Reexamining the Pathogenicity and Elimination of Parasites in Rats and Mice 21-26
Emerging (and Reemerging) Viruses of Laboratory Mice and Rats 27-34
Emerging Infections as a Cause of Concern 35-39
Emerging Diseases in Mice and Rats 40-43
Survey of Heliobacter Species in Laboratory Mice and Gerbils in Japan 44-46
Genetic Evaluation of Outbred Rats 47-50
Genetic Evaluation of Outbred Rats from the Breeder's Perspective 51-64
Concept for Establishment of Rat Outbred Global Standard Strains 65-76
Necessity of Genetic and Microbiologic Quality Network from the Pharmaceutical Industry's Perspective 77-84
International Harmonization of Laboratory Animals 85-96
Rat Genetics and Toxicology 97-104
A Phenotype-driven Approach to the Molecular and Functional Analysis of the Mouse Genome 105-115
Evaluation of Targeted Mutations 116-118
Defining Behavioral Phenotypes in Transgenic and Knockout Mice 119-129
Defining Phenotype in Genetically Engineered Mice 130-131
Development of the Mouse Model Dramatype for Human Clinical Benefit 132-136
Concluding Remarks 137-137
Implication of Wild-derived Genes, Mitochondria, and Chromosomes in the Genetic Background of Mouse Models for Diseases and Biologic Functions 138-141
Concluding Comments, John Strandberg 142-143
Concluding Remarks, John Vandenbergh 144-146
Appendix A 147-148
Appendix B 149-150
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Suggested Citation

National Research Council. Microbial Status and Genetic Evaluation of Mice and Rats: Proceedings of the 1999 US/Japan Conference. Washington, DC: The National Academies Press, 2000.

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