Perchlorate a powerful oxidant used in solid rocket fuels by the military and aerospace industry has been detected in public drinking water supplies of over 11 million people at concentrations of at least 4 parts per billion (ppb). High doses of perchlorate can decrease thyroid hormone production by inhibiting the uptake of iodide by the thyroid. Thyroid hormones are critical for normal growth and development of the central nervous system of fetuses and infants. This report evaluates the potential health effects of perchlorate and the scientific underpinnings of the 2002 draft risk assessment issued by the U.S. Environmental Protection Agency (EPA).
The report finds that the body can compensate for iodide deficiency, and that iodide uptake would likely have to be reduced by at least 75% for months or longer for adverse health effects, such as hypothryroidism, to occur. The report recommends using clinical studies of iodide uptake in humans as the basis for determining a reference dose rather than using studies of adverse health effects in rats that serve as EPA s basis. The report suggests that daily ingestion of 0.0007 milligrams of perchlorate per kilograms of body weight an amount more than 20 times the reference dose proposed by EPA should not threaten the health of even the most sensitive populations.
Table of Contents
|2 The Thyroid and Disruption of Thyroid Function in Humans||35-74|
|3 Epidemiologic Studies of Occupational and Environmental Exposures to Perchlorate||75-114|
|4 Animal Studies||115-163|
|5 Risk Characterization of Perchlorate||164-181|
|6 Research Recommendations||182-198|
|Appendix A Biographic Information on the Committee to Assess the Health Implications of Perchlorate Ingestion||199-204|
|Appendix B Glossary||205-212|
|Appendix C Participants at Public Sessions||213-215|
|Appendix D Sensitivity of Perchlorate-Induced Iodide Uptake Inhibition to Serum Iodide Concentrations||216-218|
|Appendix E Physiologically Based Pharmacokinetic Modeling||219-260|
Find relevant information like your own rough draft from among the thousands of reports available for free at NAP.edu. Copy and paste up to 8 pages of content—whether from your own draft or an outside article—and Reference Finder will recommend NAP publications related to your text.
View Reference Finder
The National Academies Press (NAP) has partnered with Copyright Clearance Center's Rightslink service to offer you a variety of options for reusing NAP content. Through Rightslink, you may request permission to reprint NAP content in another publication, course pack, secure website, or other media. Rightslink allows you to instantly obtain permission, pay related fees, and print a license directly from the NAP website. The complete terms and conditions of your reuse license can be found in the license agreement that will be made available to you during the online order process. To request permission through Rightslink you are required to create an account by filling out a simple online form. The following list describes license reuses offered by the National Academies Press (NAP) through Rightslink:
Click here to obtain permission for the above reuses. If you have questions or comments concerning the Rightslink service, please contact:
Rightslink Customer Care
Tel (toll free): 877/622-5543
To request permission to distribute a PDF, please contact our Customer Service Department at 800-624-6242 for pricing.
To request permission to translate a book published by the National Academies Press or its imprint, the Joseph Henry Press, please click here to view more information.
Loading stats for Health Implications of Perchlorate Ingestion...