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Drinking Water and Health, Volume 9

Selected Issues in Risk Assessment

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Status: Available Now

Size: 284 pages, 6 x 9

Publication Year:1989


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ISBN-10: 0-309-03897-9
ISBN-13: 978-0-309-03897-3
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Authors:
Safe Drinking Water Committee, National Research Council
Authoring Organizations

Description:
The National Research Council closes the landmark series Drinking Water and Health with Volume 9, published in two parts:
Part I: DNA Adducts provides an overview of DNA adducts and their effects on human health, explores the techniques currently in use ...
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Table of Contents
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Front Matter i-xiv  
Part I: DNA Adducts 1-2 (skim)
Executive Summary 3-5 (skim)
1 Biologic Significance of DNA Adducts and Protein Adducts 6-37 (skim)
2 DNA-Adduct Technology 38-56 (skim)
3 Conclusions and Recommendations 57-60 (skim)
Appendix A: Drinking Water Contaminant Candidates for Development of Baseline Data on Formation of DNA Adducts 61-78 (skim)
Glossary 79-88 (skim)
Biographical Sketches 89-92 (skim)
Part II: Mixtures 93-94 (skim)
Executive Summary 95-100 (skim)
1 Introduction 101-107 (skim)
2 Pharmacokinetics and the Risk Assessment of Drinking Water Contaminants 108-120 (skim)
3 Risk Assessment of Mixtures of Systemic Toxicants in Drinking Water 121-132 (skim)
4 Assessment of Exposure to Organophosphorus Conpounds, Carbamates, and Volatile Organic Chemicals 133-145 (skim)
5 Acetylcholinesterase Inhibitors: Case Study of Mixtures of Contaminates with Similar Biologic Effects 146-161 (skim)
6 Volatile Organic Compounds (VOCs): Risk Assessment of Mixtures of Potentially Carcinogenic Chemicals 162-167 (skim)
7 Conclusions and Recommendations for Research 168-170 (skim)
Appendix A: An Approach for Risk Assessment of Volatile Organic Chemicals in Drinking Water That Uses Experimental Inhalation Data and a Physiologically Based Pharmacokinetic Model 171-174 (skim)
Appendix B: A Model Illustrating Synergism 175-176 (skim)
Appendix C: Models of Response: Dose Additivity and Response Additivity 177-181 (skim)
Biographical Sketches 182-184 (skim)
Part III: Cumulative Index 185-186 (skim)
Index 187-268 (skim)

Description

The National Research Council closes the landmark series Drinking Water and Health with Volume 9, published in two parts:
Part I: DNA Adducts provides an overview of DNA adducts and their effects on human health, explores the techniques currently in use for detecting them, offers an outlook on future toxicity testing, and lists specific recommendations for action.
Part II: Mixtures explores the issues surrounding multiple-chemical exposure from drinking water and reviews options for grouping compounds so their toxicity in mixtures can be reliably assessed. The book describes alternative approaches and considers the option of developing a modified "hazard index" for chemical compounds.

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