Table of Contents
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Front Matter	i-xviii
Executive Summary	1-12	(skim)
1 Introduction	13-38	(skim)
2 Silicone Chemistry	39-53	(skim)
3 Implant Catalogue	54-79	(skim)
4 Silicone Toxicology	80-113	(skim)
5 Reoperations and Specific Local and Perioperative Complications	114-178	(skim)
6 Immunology of Silicone	179-197	(skim)
7 Antinuclear Antibodies and Silicone Breast Implants	198-214	(skim)
8 Epidemiological Studies of Connective Tissue or Rheumatic Diseases and Breast Implants	215-232	(skim)
9 Silicone Breast Implants and Cancer	233-241	(skim)
10 Neurological Disease and Its Association with Silicone Breast Implants	242-247	(skim)
11 Effects on Pregnancy, Lactation, and Children	248-263	(skim)
12 Silicone Implants and Breast Imaging	264-284	(skim)
Reference Lists	285-480	(skim)
Appendix A: Brief Description of the Scientific Workshop	481-487	(skim)
Appendix B: Description of the Public Meeting	488-504	(skim)
Appendix C: Review of the Reports of the Independent Review Group and the National Science Panel	505-514	(skim)
Appendix D: Glossary	515-524	(skim)
Index	525-540	(skim)

Description

The Dow Corning case raised serious questions about the safety of silicone breast implants and about larger issues of medical device testing and patient education.

Safety of Silicone Breast Implants presents a well-documented, thoughtful exploration of the safety of these devices, drawing conclusions from the available research base and suggesting further questions to be answered. This book also examines the sensitive issues surrounding women's decisions about implants. In reaching conclusions, the committee reviews:

• The history of the silicone breast implant and the development of its chemistry.
  
• The wide variety of U.S.-made implants and their regulation by the Food and Drug Administration.
  
• Frequency and consequences of local complications from implants.
  
• The evidence for and against links between implants and autoimmune disorders, connective tissue disease, neurological problems, silicone in breast milk, or a proposed new syndrome.
  
• Evidence that implants may be associated with lower frequencies of breast cancer.
  

Safety of Silicone Breast Implants provides a comprehensive, well-organized review of the science behind one of the most significant medical controversies of our time.

Authoring Organizations

• Institute of Medicine (IOM)
• More Titles from IOM

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