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| TABLE 2.1 Landmark Discoveries Since the 1982 IOM Report |
| Year | Discovery | Primary Investigators |
| 1986 | Potent cannabinoid agonists are developed; they are the key to discovering the receptor. | M. R. Johnson and L. S. Melvin75 |
| 1988 | First conclusive evidence of specific cannabinoid receptors. | A. Howlett and W. Devane36 |
| 1990 | The cannabinoid brain receptor (CB1) is cloned, its DNA sequence is identified, and its location in the brain is determined. | L. Matsuda107 and M. Herkenham et al.60 |
| 1992 | Anandamide is discovered--a naturally occurring substance in the brain that acts on cannabinoid receptors. | R. Mechoulam and W. Devane37 |
| 1993 | A cannabinoid receptor is discovered outside the brain; this receptor (CB2) is related to the brain receptor but is distinct. | S. Munro112 |
| 1994 | The first specific cannabinoid antagonist, SR 141716A, is developed. | M. Rinaldi-Carmona132 |
| 1998 | The first cannabinoid antagonist, SR144528, that can distinguish between CB1 and CB2 receptors discovered. | M. Rinaldi-Carmona133 |