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Mineral Tolerance of Domestic Animals (1980)
Board on Agriculture (BOA)

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MIKICD A I TOLERANCE OF DOMESTIC ANIMALS SUBCOMMIIlEE ON MINERAL TOXICITY IN ANIMALS Committee on Animal Nutrition Board on Agriculture and Renewable Resources Commission on Natural Resources National Research Council NATIONAL ACADEMY OF SCIENCES Washington, D.C. l9B0

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NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineenng, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competencies and with regard for appropriate balance. Lois report has been reviewed by a group other than the authors according to proce- dures approved by a Report Review Committee consisting of members of the National Academy of Sciences, the National Academy of Engineenng, and the Institute of Medicine. This study was supported by the Bureau of Veterinary Medicine, Food and Drug Ad- m~s~ation of the U.S. Department of Health and Human Services; by Agncultural Research, Science and Education Administration of the U.S. Department of Agriculture; and by the National Feed Ingredients Association. Library of As Cataloging ~ Publicadm ~" National Research Council. Subcommittee on Mineral Toxicity in Animals. Mineral tolerance of domestic animals. Bibliography: p. 1. Veterinary toxicology. nutntion. I. Title. SF 757.5.N27 1980 ISBN 0-309 03022-6 Available from National Academy Press National Academy of Sciences 2101 Constitution Avenue, N.W. Washington, D.C. 20418 2. Minerals in animal 636.089'59 8~15466 Printed in the United States of America First Printing, July 1980 Second Printing, September 1988 Third Printing, January 1992

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Preface The Subcommittee on Mineral Toxicity was requested by the Commit- tee on Animal Nutrition to review and evaluate the literature relating to mineral tolerance of animals and to set maximum tolerable levels of dietary minerals for domestic animals. Information for 35 minerals, including the essential elements and those traditionally considered as "toxic," was reviewed. The report emphasizes the potential adverse effects of minerals on animals, with only limited discussion of other aspects, such as essentiality and metabolism. The information should be useful to those persons involved with the formulation of diets for domestic animals. The subcommittee was fortunate in having the advice and guidance of many scientists in the review of this report. The following individuals contributed significantly to the work of the subcommittee by critically reviewing some or all chapters of the report and suggesting ways in which the report could be more useful to the scientific community: Richard A. Anderson, David H. Baker, V. R. Bohman, Ian Bremner, C. C. Calvert, Rufus L. Chaney, David C. Church, George K. Davis, Richard M. Forbes, Douglas V. Frost, Howard E. Ganther, Robert A. Goyer, Samuel L. Hansard II, Vernon R. Heaton, Roger W. Hemken, Charles H. Hill, William A. House, Norman L. Jacobson, Leo S. Jensen, P. Larvor, Roland M. Leach, Jr., Orville A. Levander, Kathryn R. Mahaffey, Walter Melts, Elwyn R. Miller, James G. Mor- r~s, Talmadge S. Nelson, Forrest H. Nielsen, Boyd L. O'Dell, Loyd Poitevint, Bobby L. Reid, G. Stanley Smith, Sedgwick E. Smith, Roy · - ~

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iv Preface F. Spalding, James F. Standish, John W. Suttie, Roger A. Teekell, and H. J. Weeth. The subcommittee is also indebted to Philip Ross, Executive Secre- tary, and Selma P. Baron, StaffOff'cer, of the Board on Agriculture and Renewable Resources for their assistance In the production of this report, to the members of the Committee on Animal Nutrition and reviewers from the Board on Agriculture and Renewable Resources and the Commission on Natural Resources for their comments and suggestions, and to Pamela R. Henry for technical assistance in the preparation of the manuscript. SUBCOMMITTEE ON MINERAL TOXICITY CLARENCE B. AMMERMAN, Chairman; University of Florida JOSEPH P. FONTENOT, VP! and State University MATnE RAE SPIVEY FOX, Food and Drug Administration, DHHS HAROLD D. HUTCHINSON, Moo~an Manufacturing Company PAUL LE~", Fob and Dog Administration, DHHS HOWARD D. STOWE, Michigan State University DAVID I. THOMSON, International Miner~s and Chemical Corporation DUANE E. UEEREY, Michigan State University

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COMMITI EE ON ANIMAL NUTRITION JOSEPH P. FONTENOT, Chairman; vP~ and State University CARL E. COPPOCK, Texas A&M University RICHARD D. GOODRICH, University of Minnesota PAUL W. MOE, USDA Nutrition Institute QUINTON R. ROGERS, University of California, Davis GARY E. RUMSEY, Tunison Laboratory of Fish Nutrition VAUGHN C. SPEER, Iowa State University JOHN D. SUPERS, University of Guelph DUANE E. UEEREY, Michigan State University BOARD ON AGRICULTURE AND RENEWABLE RESOURCES CHESTER O. McCORKLE, of., Chairman; University of California, Davis GEORGE K. DAVIS, Vice Chairman; University of Florida JOHN D. AXTEEL, Purdue University THADIS W. BOX, Utah State University ROBERT E. BUCKMAN, USDA Forest Service NEVILLE P. CLA=E, Texas A&M University ELLIS B. COWING, North Carolina State University SALLY K. FAIRFAX, University of California, Berkeley JOHN E. HALVER, University of Washington HELEN M. INGRAM, University of Arizona RALPH I. MCCRACKEN, USDA Science and Education Administration BERNARD S. SCHWEIGERT, University of California, Davis GEORGE R. STAEBEER, Weyerhaeuser Company v

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Contents l Introduction Maximum Tolerable Levels Aluminum Antimony Arsenic Banum Bismuth Boron Bromine Cadmium Calcium Chromium Cobalt Copper FluoIine Iodine Iron Lead V1 3 8 24 40 54 60 71 84 93 131 142 154 162 184 227 242 256

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Magnesium Manganese Mercury Molybdenum Nickel Phosphorus Potassium Selenium Silicon Silver Sodium Chloride Strontium Super Tin Titanium Tungsten Uranium Vanadium Zinc 277 290 304 328 345 364 378 392 421 431 441 459 466 491 510 515 525 534 553 ·. V11

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