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MIKICD A I
TOLERANCE OF
DOMESTIC
ANIMALS
SUBCOMMIIlEE ON MINERAL TOXICITY IN ANIMALS
Committee on Animal Nutrition
Board on Agriculture and Renewable Resources
Commission on Natural Resources
National Research Council
NATIONAL ACADEMY OF SCIENCES
Washington, D.C. l9B0
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NOTICE: The project that is the subject of this report was approved by the Governing
Board of the National Research Council, whose members are drawn from the councils of
the National Academy of Sciences, the National Academy of Engineenng, and the
Institute of Medicine. The members of the committee responsible for the report were
chosen for their special competencies and with regard for appropriate balance.
Lois report has been reviewed by a group other than the authors according to proce-
dures approved by a Report Review Committee consisting of members of the National
Academy of Sciences, the National Academy of Engineenng, and the Institute of
Medicine.
This study was supported by the Bureau of Veterinary Medicine, Food and Drug Ad-
m~s~ation of the U.S. Department of Health and Human Services; by Agncultural
Research, Science and Education Administration of the U.S. Department of Agriculture;
and by the National Feed Ingredients Association.
Library of As Cataloging ~ Publicadm ~"
National Research Council. Subcommittee on Mineral
Toxicity in Animals.
Mineral tolerance of domestic animals.
Bibliography: p.
1. Veterinary toxicology.
nutntion. I. Title.
SF 757.5.N27 1980
ISBN 0-309 03022-6
Available from
National Academy Press
National Academy of Sciences
2101 Constitution Avenue, N.W.
Washington, D.C. 20418
2. Minerals in animal
636.089'59 8~15466
Printed in the United States of America
First Printing, July 1980
Second Printing, September 1988
Third Printing, January 1992
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Preface
The Subcommittee on Mineral Toxicity was requested by the Commit-
tee on Animal Nutrition to review and evaluate the literature relating to
mineral tolerance of animals and to set maximum tolerable levels of
dietary minerals for domestic animals. Information for 35 minerals,
including the essential elements and those traditionally considered as
"toxic," was reviewed. The report emphasizes the potential adverse
effects of minerals on animals, with only limited discussion of other
aspects, such as essentiality and metabolism. The information should
be useful to those persons involved with the formulation of diets for
domestic animals.
The subcommittee was fortunate in having the advice and guidance
of many scientists in the review of this report. The following individuals
contributed significantly to the work of the subcommittee by critically
reviewing some or all chapters of the report and suggesting ways in
which the report could be more useful to the scientific community:
Richard A. Anderson, David H. Baker, V. R. Bohman, Ian Bremner,
C. C. Calvert, Rufus L. Chaney, David C. Church, George K. Davis,
Richard M. Forbes, Douglas V. Frost, Howard E. Ganther, Robert A.
Goyer, Samuel L. Hansard II, Vernon R. Heaton, Roger W. Hemken,
Charles H. Hill, William A. House, Norman L. Jacobson, Leo S.
Jensen, P. Larvor, Roland M. Leach, Jr., Orville A. Levander,
Kathryn R. Mahaffey, Walter Melts, Elwyn R. Miller, James G. Mor-
r~s, Talmadge S. Nelson, Forrest H. Nielsen, Boyd L. O'Dell, Loyd
Poitevint, Bobby L. Reid, G. Stanley Smith, Sedgwick E. Smith, Roy
· - ~
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iv Preface
F. Spalding, James F. Standish, John W. Suttie, Roger A. Teekell, and
H. J. Weeth.
The subcommittee is also indebted to Philip Ross, Executive Secre-
tary, and Selma P. Baron, StaffOff'cer, of the Board on Agriculture and
Renewable Resources for their assistance In the production of this
report, to the members of the Committee on Animal Nutrition and
reviewers from the Board on Agriculture and Renewable Resources
and the Commission on Natural Resources for their comments and
suggestions, and to Pamela R. Henry for technical assistance in the
preparation of the manuscript.
SUBCOMMITTEE ON MINERAL TOXICITY
CLARENCE B. AMMERMAN, Chairman; University of Florida
JOSEPH P. FONTENOT, VP! and State University
MATnE RAE SPIVEY FOX, Food and Drug Administration, DHHS
HAROLD D. HUTCHINSON, Moo~an Manufacturing Company
PAUL LE~", Fob and Dog Administration, DHHS
HOWARD D. STOWE, Michigan State University
DAVID I. THOMSON, International Miner~s and Chemical Corporation
DUANE E. UEEREY, Michigan State University
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COMMITI EE ON ANIMAL NUTRITION
JOSEPH P. FONTENOT, Chairman; vP~ and State University
CARL E. COPPOCK, Texas A&M University
RICHARD D. GOODRICH, University of Minnesota
PAUL W. MOE, USDA Nutrition Institute
QUINTON R. ROGERS, University of California, Davis
GARY E. RUMSEY, Tunison Laboratory of Fish Nutrition
VAUGHN C. SPEER, Iowa State University
JOHN D. SUPERS, University of Guelph
DUANE E. UEEREY, Michigan State University
BOARD ON AGRICULTURE AND RENEWABLE RESOURCES
CHESTER O. McCORKLE, of., Chairman; University of California, Davis
GEORGE K. DAVIS, Vice Chairman; University of Florida
JOHN D. AXTEEL, Purdue University
THADIS W. BOX, Utah State University
ROBERT E. BUCKMAN, USDA Forest Service
NEVILLE P. CLA=E, Texas A&M University
ELLIS B. COWING, North Carolina State University
SALLY K. FAIRFAX, University of California, Berkeley
JOHN E. HALVER, University of Washington
HELEN M. INGRAM, University of Arizona
RALPH I. MCCRACKEN, USDA Science and Education Administration
BERNARD S. SCHWEIGERT, University of California, Davis
GEORGE R. STAEBEER, Weyerhaeuser Company
v
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Contents
l
Introduction
Maximum Tolerable Levels
Aluminum
Antimony
Arsenic
Banum
Bismuth
Boron
Bromine
Cadmium
Calcium
Chromium
Cobalt
Copper
FluoIine
Iodine
Iron
Lead
V1
3
8
24
40
54
60
71
84
93
131
142
154
162
184
227
242
256
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Magnesium
Manganese
Mercury
Molybdenum
Nickel
Phosphorus
Potassium
Selenium
Silicon
Silver
Sodium Chloride
Strontium
Super
Tin
Titanium
Tungsten
Uranium
Vanadium
Zinc
277
290
304
328
345
364
378
392
421
431
441
459
466
491
510
515
525
534
553
·.
V11
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