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Science and Judgment in Risk Assessment (1994)
Board on Environmental Studies and Toxicology (BEST)

Page
XI
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Page xi

Contents

EXECUTIVE SUMMARY

1

1

INTRODUCTION

16

 

Charge to the Committee

17

 

Conceptual Framework of the Report

21

PART I
CURRENT APPROACHES TO RISK ASSESSMENT

23

2

RISK ASSESSMENT AND ITS SOCIAL AND REGULATORY CONTEXTS

25

 

General Concepts

25

 

Historical Roots

29

 

NRC Study of Risk Assessment in the Federal Government

33

 

Events After Release of the 1983 NRC Report

34

 

Uses of Risk Assessment in the Regulation of Hazardous Air Pollutants

36

 

Noncancer Risk Associated with Hazardous Air Pollutants

39

 

Public Criticism of Conduct and Uses of Risk Assessment

40

3

EXPOSURE ASSESSMENT

43

 

Introduction

43

 

Emission Characterization

47

 

Modeling Used in Exposure Assessment

50

Page
XI
Front Matter (R1-R16)
Executive Summary (1-15)
1 Introduction (16-22)
Part I Current Approaches to Risk Assessment: 2 Risk Assessment and its Social and Regulatory Contexts (23-42)
3 Exposure Assessment (43-55)
4 Assessment of Toxicity (56-67)
5 Risk Characterization (68-78)
Part II Strategies for Improving Risk Assessment: 6 Default Options (79-105)
7 Models, Methods, and Data (106-143)
8 Data Needs (144-159)
9 Uncertainty (160-187)
10 Variability (188-223)
11 Aggregation (224-242)
Part III Implementation of Findings: 12 Implementation (243-268)
References (269-286)
Appendix A: Risk Assessment Methodologies: EPA (287-350)
Appendix B: EPA Memorandum from Henry Habicht (351-374)
Appendix C: Calculation and Modeling of Exposure (375-382)
Appendix D: Working Paper for Considering Draft Revisions to the U.S. EPA Guidelines for Cancer Risk Assessment (383-448)
Appendix E: Use of Pharmacokinetics to Extrapolate from Animal Data to Humans (449-452)
Appendix F: Uncertainty Analysis of Health Risk Estimates (453-478)
Appendix G: Improvement in Human Health Risk Assessment Utilizing Site- and Chemical-Specific Information: A Case Study (479-502)
Appendix H-1: Some Definitional Concerns About Variability (503-504)
Appendix H-2: Individual Susceptibility Factors (505-514)
Appendix I: Aggregation (515-536)
Appendix J: A Tiered Modeling Approach for Assessing the Risks Due to Sources of Hazardous Air Pollutants (537-582)
Appendix K: Science Advisory Board Memorandum on the Integrated Risk Information System and EPA Response (583-590)
Appendix L: Development of Data Used in Risk Assessment (591-598)
Appendix M: Charge to the Committee (599-600)
Appendix N-1: The Case for (601-628)
Appendix N-2: Making Full Use of Scientific Information in Risk Assessment (629-640)
Index (641-652)