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Toxicological Effects of Methylmercury
C ONTENTS
EXECUTIVE SUMMARY
1
1
INTRODUCTION
13
Sources of Hg,
15
Fate and Transport,
16
Health Effects,
16
Exposure Events and Studies,
18
Summary of Risk Assessments for MeHg,
21
Scientific Controversies and Sources of Uncertainty,
26
Organization of the Report,
26
References,
27
2
CHEMISTRY, EXPOSURE, TOXICOKINETICS, AND TOXICODYNAMICS
31
Physical and Chemical Properties,
31
Methods of Chemical Analysis,
37
Exposures to MeHg in the U.S. Population,
38
Toxicokinetics,
42
Mobilization of Body Hg,
51
Chemical Forms of Hg in Toxicity,
52
Toxic Effects and Target Organs,
53
Biochemical Mechanisms of Toxicity,
54
Summary and Conclusions,
58
Recommendations,
60
References,
60
