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Suggested Citation:"References." National Research Council. 2000. Strategies That Influence Cost Containment in Animal Research Facilities. Washington, DC: The National Academies Press. doi: 10.17226/10006.
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References

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Capecchi, Mario R. 1989. Altering the genome by homologous recombination. Science 244: 1288-1292.

Gehrke, B. C., B. J. Weigler, and M. M. Slattum. 2000. Professional income of laboratory animal veterinarians predicted by multiple regression analysis. J Am Vet Med Assoc 216: 852-858.

Greger, J. 1995. Just in Time Report to NRC Round Table, December 7, 1995. Washington, DC: National Academy Press.

Houghtling, J. L. 1998. Outsourcing your animal care program. Lab Anim 27(9): 35-39.

Lipman, N. S. 1999. Isolator rodent caging systems (state of the art): A critical review. Contemp. Top Lab Anim Sci 38(1): 9-17.

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NIH [National Institutes of Health]. 1999. NIH Initiative to Reduce Regulatory Burden: Identification of Issues and Potential Solutions, edited by J.D. Mahoney. http:// grants.nih.gov/grants/policy/regulatoryburden/index.htm.

NIH [National Institutes of Health]. 2000. Cost Analysis and Rate Setting Manual for Animal Research Facilities NIH Committee on Revision of Cost Analysis and Rate Setting Manual for Animal Research Facilities. NIH Publication No 00-2006. Bethesda, MD: US Department of Health and Human Services, National Institutes of Health, National Center for Research Resources.

NRC [National Research Council]. 1998. Approaches to Cost Recovery for Animal Research: Implications for Science, Animals, Research Competitiveness, and Regulatory Compliance Washington, DC: National Academy Press.

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Suggested Citation:"References." National Research Council. 2000. Strategies That Influence Cost Containment in Animal Research Facilities. Washington, DC: The National Academies Press. doi: 10.17226/10006.
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NRC [National Research Council]. 1996b. Rodents: Laboratory Animal Management. Washington, DC: National Academy Press. P 167.

Perkins, S. E., and N. S. Lipman. 1995. Characterization and qualification of microenvironmental contaminants in isolator cages with a variety of contact beddings. Contemp Top Lab Anim Sci 34(3): 93-98.

Perkins, S. E., and N. S. Lipman. 1996. Evaluation of microenvironmental conditions and noise generation in three individually ventilated rodent caging systems and static isolator cages. Contemp Top Lab Anim Sci 35(2): 61-65.

Reeb, C. K., R. B. Jones, D. W. Bearg, H. Bedigian, D. D. Myers, and B. Paigen. 1998. Microenvironment in ventilated animal cages with differing ventilation rates, mice populations, and frequency of bedding changes. Contemp Top Lab Anim Sci 37(2): 43-49.

Suggested Citation:"References." National Research Council. 2000. Strategies That Influence Cost Containment in Animal Research Facilities. Washington, DC: The National Academies Press. doi: 10.17226/10006.
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Suggested Citation:"References." National Research Council. 2000. Strategies That Influence Cost Containment in Animal Research Facilities. Washington, DC: The National Academies Press. doi: 10.17226/10006.
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Page 60
Suggested Citation:"References." National Research Council. 2000. Strategies That Influence Cost Containment in Animal Research Facilities. Washington, DC: The National Academies Press. doi: 10.17226/10006.
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Page 61
Suggested Citation:"References." National Research Council. 2000. Strategies That Influence Cost Containment in Animal Research Facilities. Washington, DC: The National Academies Press. doi: 10.17226/10006.
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Page 62
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Care and use of animals in research are expensive, prompting efforts to contain or reduce costs. Components of those costs are personnel, regulatory compliance, veterinary medical care, and laboratory animal management, equipment, and procedures. Many efforts have been made to control and reduce personnel costs, the largest contributing factor to cost, through better facility and equipment design, more efficient use of personnel, and automation of many routine operations. However, there has been no comprehensive, recent analysis of the various cost components or examination of the strategies that have been proven or are purported to decrease the cost of animal facility operation.

Strategies that Influence Cost Containment in Animal Research Facilities examines the current interpretation of governmental policy (Office of Management and Budget Circular A-21) concerning institutional reimbursement for overhead costs of an animal research facility and describes methods for economically operating an animal research facility. This report develops recommendations by which federal auditors and research institutions can establish what cost components of research animal facilities should be charged to institutions' indirect cost pool and what animal research facility cost components should be included in the per diem charges to investigators, and assesses the financial and scientific ramifications that these criteria would have among federally funded institutions. Further, the report determines the cost components of laboratory animal care and use in biomedical research and assesses and recommends methods of cost containment for institutions maintaining animals for biomedical research.

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