clarification of Circulars A-21 and A-122 (Action Transmittal OGAM AT 2000-1, dated November 15, 1999, Appendix A) to authorize the allocation of some costs to the F&A cost pool as suggested by the committee. Specifically, those costs were related to procedure rooms, operating and recovery rooms, isolation rooms, quarantine rooms directly related to research protocols, and rooms that house research animals that are not generally removed from the facility for conducting research. Institutions are still required to document, through space surveys, the particular research projects conducted in research space included in the F&A pool. Given those clarifications, an NIH committee completed work on a year 2000 revision of A Cost Analysis and Rate Setting Manual for Animal Research Facilities (CARS Manual). The manual was originally produced by NIH in 1974 and revised in 1979. It has been widely used for cost analysis and rate setting in animal research facilities. The 2000 revision of the manual will bring it up to date with federal cost policies and the technical evolution in the animal research facilities.

The ILAR committee's final objective was to analyze the costs entailed in the care and use of animals in biomedical research and to develop useful indicators for institutions to use in scaling their performance efficiency and evaluating their overall support systems for research animals. The committee was also given the charge of assessing and recommending methods of cost containment for institutions that maintain animals for biomedical research. The committee has drawn on a variety of sources to meet its objectives, including published reports in the literature, personal communications with experts in the field, the opinions of the committee's own members, and two survey documents that were available in whole or in part to the committee. The main survey document used by the committee was the 1999 Animal Resources Survey (1999 ARS), conducted by the Yale University School of Medicine's Section of Comparative Medicine and analyzed by the Division of Biomathematics and Biostatistics in the Columbia University Department of Pediatrics. Of 130 academic institutions contacted (including the top 100 recipients of NIH funds for 1995), 63 responded to the survey, for a nearly 50% response rate. The total research budget was greater than $50 million for 42 institutions, between $10 and $50 million for 15, and less than $10 million for six. The 1999 ARS questionnaire and a tabular summary of the findings are provided in Appendix C. The survey produced a wealth of descriptive information needed to characterize many variables relevant to contemporary animal care and use programs and practices, but it failed to yield detailed and compelling information about the linkage of costs to the quality of animal care in many areas. Also, a summary of the conclusions, but not the underlying data, of a survey conducted by the Ohio State University, Office of Research, for the Committee for Institutional



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