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of the member to a chemical warfare agent or other hazardous material to which the member was exposed during active military service. The Department of Defense is required to develop a plan for compliance.

As a part of its efforts to protect military and civilian personnel from reproductive and developmental hazards in the workplace, the Navy requested that the National Research Council (NRC) recommend an approach that can be used to evaluate sources of potential reproductive and developmental toxicity. The NRC assigned this project to the Committee on Toxicology, which convened the Subcommittee on Reproductive and Developmental Toxicology. The subcommittee was assigned the following tasks:

  • Develop a process for assessing the reproductive and developmental toxicity potential from exposures to chemicals and physical agents.

  • Develop a strategy for dealing with the potential reproductive and developmental toxicity of exposures to chemicals and physical agents for which little or no information is available.

  • Conduct pilot evaluations on two chemicals using the process developed by the subcommittee.

  • Identify reliable sources for assessment of reproductive and developmental toxicity.

  • Identify areas of needed research.

In this report, the subcommittee recommends an approach to assess potential reproductive and developmental toxicity from exposures to substances encountered in workplaces operated by the United States Navy.


The subcommittee's major conclusions and recommendations, organized in response to each of its tasks, are presented below.

Evaluative Process

The subcommittee's recommended approach for evaluating exposures to chemicals and physical agents for reproductive and develop-

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