mg/day), vanadium (1.8 mg/day), and zinc (40 mg/day), as shown in Table S-10, were set to protect the most sensitive individuals in the general population (such as those who might be below the reference adult weight).

Members of the general, apparently healthy population should be advised not to routinely exceed the UL. However, intake above the UL may be appropriate for investigation within well-controlled clinical trials to ascertain if such intakes are of benefit to health for specific reasons. Clinical trials of doses above the UL should not be discouraged, as it is expected that participation in these trials will require informed consent that will include discussion of the possi-