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Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc (2001)
Food and Nutrition Board (FNB)
Institute of Medicine (IOM)

Citation Manager

. "7 Copper." Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: The National Academies Press, 2001.

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Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc

Reference

Study Group

Stage of Lactation

Milk Concentration (μg/L)

Estimated Copper Intake of Infants (μg/d)a

Butte et al., 1987

45 women

1 mo

 

270

2 mo

230

3 mo

210

4 mo

200

Casey et al., 1989

22 women

7 d

620

480

5 mo

220

170

Anderson, 1992

7 women

Up to 5 mo

310

240

Anderson, 1993

6 women, 20–30 y

 

110–380

 

Biego et al., 1998

17 milk samples

Mature milk

250

190

Rossipal and Krachler, 1998

46 women

1–3 d

570

440

42–60 d

230

180

97–293 d

150

90

NOTE: Maternal intakes were reported in only two studies: in Vaughan et al. (1979), mean intakes (mg/day) were 3.64, 1.90, 2.37, 6.80, and 2.50 at 4–6, 7–9, 10–12, 13–18, and 19–31 months; in Vuori et al. (1980), mean intakes (mg/day) were 1.88 at 6–8 weeks and 1.73 at 17–22 weeks.

a Copper intake based on reported data or concentration (μg/L) × 0.78 L/day for 0–6 months postpartum and concentration (μg/L) × 0.6 L/day for 7–12 months postpartum.

National Health and Nutrition Examination Survey, the median copper intake from weaning food for children aged 7 through 12 months is 100 μg/day (n = 45). The average copper concentration in human milk declines over time, and between 7 and 12 months postpartum the concentration is 200 μg/L or less (Table 7-1). Based on an average volume of 0.6 L/day of human milk that is secreted, the copper intake from human milk is 120 μg/day (0.6 × 200). Therefore the total intake of copper from human milk and complementary foods is 220 μg/day (120 + 100). For a 9 kg infant (reference weight 7 through 12 months, Chapter 2), this would be 24 μg/ kg/day (220 μg/kg ÷ 9 kg).

If the AI were extrapolated from the AI for younger infants by using the calculation in chapter 2, the average intake would be 241 μg/day.

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237
Front Matter (R1-R24)
Summary (1-28)
1 Introduction to Dietary Reference Intakes (29-43)
2 Overview and Methods (44-59)
3 A Model for the Development of Tolerable Upper Intake Levels (60-81)
4 Vitamin A (82-161)
5 Vitamin K (162-196)
6 Chromium (197-223)
7 Copper (224-257)
8 Iodine (258-289)
9 Iron (290-393)
10 Manganese (394-419)
11 Molybdenum (420-441)
12 Zinc (442-501)
13 Arsenic, Boron, Nickel, Silicon, and Vanadium (502-553)
14 Uses of Dietary Reference Intakes (554-579)
15 A Research Agenda (580-586)
Appendix A Origin and Framework of the Development of Dietary Reference Intake (587-590)
Appendix B Acknowledgments (591-593)
Appendix C Dietary Intake Data from the Third National Health and Nutrition Examination Survey (NHANES III), 1988-1994 (594-643)
Appendix D Dietary Intake Data from the Continuing Survey of Food Intakes by Individuals (CSFII), 1994-1996 (644-653)
Appendix E Dietary Intake Data from the U.S. Food and Drug Administration Total Diet Study, 1991-1997 (654-673)
Appendix F Canadian Dietary Intake Data, 1990 (674-679)
Appendix G Biochemical Indicators for Iron, Vitamin A, and Iodine from the Third National Health and Nutrition Examination Survey (NHANES III), 1988-1994 (680-691)
Appendix H Comparison of Vitamin A and Iron Intake and Biochemical Indicators from the Third National Health and Nutrition Examination Survey (NHANES III), 1988-1994 (692-696)
Appendix I Iron Intakes and Estimated Percentile of the Distribution of Iron Requirements from the Continuing Survey of Food Intakes by Individuals (CSFII), 1994-1996 (697-703)
Appendix J Glossary and Acronyms (704-708)
Appendix K Conversion of Units (709-709)
Appendix L Options for Dealing with Uncertainties (710-714)
Appendix M Biographical Sketches of Panel and Subcommittee Members (715-728)
Index (729-769)
Summary Table, Dietary Reference Intakes: Recommended Intakes for Individuals, Vitamins (770-771)
Summary Table, Dietary Reference Intakes: Recommended Intakes for Individuals, Elements (772-773)