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Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc (2001)
Food and Nutrition Board (FNB)
Institute of Medicine (IOM)

Citation Manager

. "10 Manganese." Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: The National Academies Press, 2001.

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Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc

Sandstrom B, Davidsson L, Eriksson R, Alpsten M, Bogentoft C. 1987. Retention of selenium (75Se), Zinc (65Zn) and manganese (54Mn) in humans after intake of a labelled vitamin and mineral supplement. J Trace Elem Electrolytes Health Dis 1:33–38.

Sandstrom B, Davidsson L, Erickson RA, Alpsten M. 1990. Effects of long-term trace element supplementation on blood trace element levels and absorption of (75Se), (54Mn), and (65Zn). J Trace Elem Electrolytes Health Dis 4:65–72.

Schroeder HA, Balassa JJ, Tipton IH. 1966. Essential trace metals in man: Manganese. A study in homeostasis. J Chron Dis 19:545–571.

Senturk UK, Oner G. 1996. The effect of manganese-induced hypercholesterolemia on learning in rats. Biol Trace Elem Res 51:249–257.

Spahr L, Butterworth RF, Fontaine S, Bui L, Therrien G, Milette PC, Lebrun LH, Zayed J, LeBlanc A, Pomier-Layrargues G. 1996. Increased blood manganese in cirrhotic patients: Relationship to pallidal magnetic resonance signal hyper-intensity and neurological symptoms. Hepatology 24:1116–1120.

Spencer H, Asmussen CR, Holtzman RB, Kramer L. 1979. Metabolic balances of cadmium, copper, manganese, and zinc in man. Am J Clin Nutr 32:1867–1875.

Stastny D, Vogel RS, Picciano MF. 1984. Manganese intake and serum manganese concentration of human milk-fed and formula-fed infants. Am J Clin Nutr 39:872–878.

Strause L, Saltman P. 1987. Role of manganese in bone metabolism. In: Kies C, ed. Nutritional Bioavailability of Manganese. Washington, DC: American Chemical Society. Pp. 46–55.

Strause L, Hegenauer J, Saltman P, Cone R, Resnick D. 1986. Effects of long-term dietary manganese and copper deficiency on rat skeleton. J Nutr 116:135–141.

Strause L, Saltman P, Glowacki J. 1987. The effect of deficiencies of manganese and copper on osteoinduction and on resorption of bone particles in rats. Calcif Tissue Int 41:145–150.


Velazquez SF, Du JT. 1994. Derivation of the reference dose for manganese. In: Mertz W, Abernathy CO, Olin SS, eds. Risk Assessment of Essential Elements. Washington, DC: ILSI Press. Pp. 253–266.

Vieregge P, Heinzow B, Korf G, Teichert HM, Schleifenbaum P, Mosinger HU. 1995. Long term exposure to manganese in rural well water has no neurological effects. Can J Neurol Sci 22:286–289.


Zidenberg-Cherr S, Keen CL, Lonnerdal B, Hurley LS. 1983. Superoxide dismutase activity and lipid peroxidation in the rat: Developmental correlations affected by manganese deficiency. J Nutr 113:2498–2504.

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Front Matter (R1-R24)
Summary (1-28)
1 Introduction to Dietary Reference Intakes (29-43)
2 Overview and Methods (44-59)
3 A Model for the Development of Tolerable Upper Intake Levels (60-81)
4 Vitamin A (82-161)
5 Vitamin K (162-196)
6 Chromium (197-223)
7 Copper (224-257)
8 Iodine (258-289)
9 Iron (290-393)
10 Manganese (394-419)
11 Molybdenum (420-441)
12 Zinc (442-501)
13 Arsenic, Boron, Nickel, Silicon, and Vanadium (502-553)
14 Uses of Dietary Reference Intakes (554-579)
15 A Research Agenda (580-586)
Appendix A Origin and Framework of the Development of Dietary Reference Intake (587-590)
Appendix B Acknowledgments (591-593)
Appendix C Dietary Intake Data from the Third National Health and Nutrition Examination Survey (NHANES III), 1988-1994 (594-643)
Appendix D Dietary Intake Data from the Continuing Survey of Food Intakes by Individuals (CSFII), 1994-1996 (644-653)
Appendix E Dietary Intake Data from the U.S. Food and Drug Administration Total Diet Study, 1991-1997 (654-673)
Appendix F Canadian Dietary Intake Data, 1990 (674-679)
Appendix G Biochemical Indicators for Iron, Vitamin A, and Iodine from the Third National Health and Nutrition Examination Survey (NHANES III), 1988-1994 (680-691)
Appendix H Comparison of Vitamin A and Iron Intake and Biochemical Indicators from the Third National Health and Nutrition Examination Survey (NHANES III), 1988-1994 (692-696)
Appendix I Iron Intakes and Estimated Percentile of the Distribution of Iron Requirements from the Continuing Survey of Food Intakes by Individuals (CSFII), 1994-1996 (697-703)
Appendix J Glossary and Acronyms (704-708)
Appendix K Conversion of Units (709-709)
Appendix L Options for Dealing with Uncertainties (710-714)
Appendix M Biographical Sketches of Panel and Subcommittee Members (715-728)
Index (729-769)
Summary Table, Dietary Reference Intakes: Recommended Intakes for Individuals, Vitamins (770-771)
Summary Table, Dietary Reference Intakes: Recommended Intakes for Individuals, Elements (772-773)