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The following HTML text is provided to enhance online readability. Many aspects of typography translate only awkwardly to HTML. Please use the page image as the authoritative form to ensure accuracy. Page ii NATIONAL ACADEMY PRESS 2101 Constitution Avenue, N.W. Washington, D.C. 20418 NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance. This report has been prepared with funds provided by the Department of Energy, grant DEFG02-94ER61939, and the National Cancer Institute, contract No. N01-OD-4-2139. ISBN 0-309-07335-9 Copyright 2001 by the National Academy of Sciences. All rights reserved. Printed in the United States of America.
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