Appendix D
Example of a Table of Contents of A Technical Support Document

TABLE OF CONTENTS



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OCR for page 179
Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals Appendix D Example of a Table of Contents of A Technical Support Document TABLE OF CONTENTS     PREFACE   2     LIST OF TABLES   5     SUMMARY   6 1.   INTRODUCTION   9 2.   HUMAN TOXICITY DATA   10     2.1. Acute Lethality   10     2.2. Nonlethal Toxicity   10     2.2.1. Acute Studies   10     2.2.2. Epidemiologic Studies   11     2.3. Developmental/Reproductive Toxicity   11     2.4. Genotoxicity   11     2.5. Carcinogenicity   11     2.6. Summary   11

OCR for page 179
Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals 3.   ANIMAL TOXICITY DATA   11     3.1. Acute Lethality   12     3.1.1. Nonhuman Primates   12     3.1.2. Dogs   12     3.1.3. Rats   12     3.1.4. Mice   13     3.1.5. Hamsters   14     3.2. Nonlethal Toxicity   14     3.2.1. Nonhuman Primates   14     3.2.2. Dogs   14     3.2.3. Rats   15     3.2.4. Mice   15     3.3. Developmental/Reproductive Toxicity   15     3.4. Genotoxicity   18     3.5. Carcinogenicity   19     3.6. Summary   19 4.   SPECIAL CONSIDERATIONS   20     4.1. Metabolism and Disposition   20     4.2. Mechanism of Toxicity   20     4.3. Structure-Activity Relationships   21     4.4. Other Relevant Information   21     4.4.1. Species Variability   21     4.4.2. Unique Physicochemical Properties   22     4.4.3. Concurrent Exposure Issues   22 5.   DATA ANALYSIS FOR AEGL-1   22     5.1. Summary of Human Data Relevant to AEGL-1   22     5.2. Summary of Animal Data Relevant to AEGL-1   22     5.3. Derivation of AEGL-1   22 6.   DATA ANALYSIS FOR AEGL-2   23     6.1. Summary of Human Data Relevant to AEGL-2   23     6.2. Summary of Animal Data Relevant to AEGL-2   23     6.3. Derivation of AEGL-2   23 7.   DATA ANALYSIS FOR AEGL-3   24     7.1. Summary of Human Data Relevant to AEGL-3   24     7.2. Summary of Animal Data Relevant to AEGL-3   24     7.3. Derivation of AEGL-3   24

OCR for page 179
Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals 8.   SUMMARY OF AEGLS   25     8.1. AEGL Values and Toxicity Endpoints   25     8.2. Comparison with Other Standards and Criteria   26     8.3. Data Adequacy and Research Needs   27 9.   REFERENCES CITED   29 Appendix A   (Derivation of AEGL Values)   32 Appendix B   (Time Scaling Calculations for Dimethylhydrazine AEGLs)   36 Appendix C   (Carcinogenicity Assessment for Dimethylhydrazine)   39 Appendix D   (Derivation Summary for Dimethylhydrazine AEGLs)   41