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Gulf War Veterans: Treating Symptoms and Syndromes (2001)

Chapter: Appendix C: Unique Considerations in Chronic Fatigue Syndrome

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Suggested Citation:"Appendix C: Unique Considerations in Chronic Fatigue Syndrome." Institute of Medicine. 2001. Gulf War Veterans: Treating Symptoms and Syndromes. Washington, DC: The National Academies Press. doi: 10.17226/10185.
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Appendix C Unique Considerations in Chronic Fatigue Syndrome

Although fatigue is a common symptom, it is also one that is vague, imprecise, and nonspecific. One of the essential problems in the study and measurement of fatigue, either as a singular entity or as a component of a more well-defined disorder, is the failure to differentiate various types of fatigue. In Chronic Fatigue and Its Syndromes (Wessely et al. 1998), the authors challenge the reader to try a “thought experiment” that clearly illustrates the dilemma encountered in defining and assessing fatigue. Below, their experiment has been expanded and modified; however, the message regarding the problems encountered in defining fatigue remains intact.

  • You run 5 miles under adverse conditions; even before starting you feel weak and daunted at the prospect. After completing only a portion of the course, you stop; the next day you are sore and tired.

  • You are asked to carefully check the references for a 600-page book on fatigue. You feel overwhelmed and really just want to ride your bike. After a few hours your eyes hurt, you are weary, your concentration diminishes, and you are making many mistakes.

  • It's flu season and you are feeling achy and weak. Your nose is running, your throat is sore, and all you want to do is go to bed.

  • You have just been up for two days finishing a grant proposal, then had to take a “red eye” and deliver the application in person to make the grant deadline.

  • You have been driving in your car for an hour. The landscape is

Suggested Citation:"Appendix C: Unique Considerations in Chronic Fatigue Syndrome." Institute of Medicine. 2001. Gulf War Veterans: Treating Symptoms and Syndromes. Washington, DC: The National Academies Press. doi: 10.17226/10185.
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Page 152

boring and you can hardly keep your eyes open. All you want to do is sleep. You also often feel like this when at home watching TV.

  • Climbing stairs has become progressively, though subtly, more difficult over the last two years.

  • Although at first, exertion is not bothersome, after 10-15 minutes, you experience constant cramping in your extremities.

  • These examples illustrate the multidimensionality of fatigue. Fatigue can occur in anticipation of a task and be influenced by both physical (e.g., the length of the run) and psychological factors (e.g., how rewarding it will be). Fatigue can also be interpreted as a sense of effort needed to perform a task, and both physical and mental tasks may result in fatigue. In conjunction with the sensation or perception of fatigue, the effort associated with a task may be manifested as a change in behavior, especially a decrement in performance (e.g., information processing declines when one feels tired). Fatigue is also most often acute, and in such cases typically resolves after completion of the task. In cases in which fatigue is more chronic and pervasive, it is frequently associated with illness, stress, and sleep disturbances. Finally, as the last two vignettes illustrate, fatigue must be distinguished from sleepiness or drowsiness and true muscle weakness since these symptoms are associated with a different array of conditions, usually primary sleep and muscle disorders.

    Thus, it is clear that a simple question regarding “fatigue” is not likely to be very informative or precise. Yet elements of fatigue can be ascertained if care is taken in questioning an individual or in constructing an instrument. However, complicating matters even more is the fact that patients often have additional meanings for fatigue. Sometimes, the word fatigue is used as a synonym for other complaints while at other times it becomes a general term to encompass an array of symptoms that occur together.

    Patients will often equate fatigue with weakness, dizziness, lack of coordination or stamina, feeling “spacey,” poor concentration/cognitive abilities, having “rubber legs,” boredom, lack of motivation, malaise, or feeling blue or depressed. Despite the further ambiguity introduced by these descriptors, it is clear that fatigue has distinct physical and mental aspects that must be considered in measurement.

    Suggested Citation:"Appendix C: Unique Considerations in Chronic Fatigue Syndrome." Institute of Medicine. 2001. Gulf War Veterans: Treating Symptoms and Syndromes. Washington, DC: The National Academies Press. doi: 10.17226/10185.
    ×
    Page 151
    Suggested Citation:"Appendix C: Unique Considerations in Chronic Fatigue Syndrome." Institute of Medicine. 2001. Gulf War Veterans: Treating Symptoms and Syndromes. Washington, DC: The National Academies Press. doi: 10.17226/10185.
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    Page 152
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    Ten years after the end of the Gulf War, questions continue to be raised about the health of U.S. service personnel who fought in that war. A primary concern is whether Gulf War veterans are receiving effective treatments for their health problems. Section 105 of the Veterans Program Enhancement Act of 1998 mandates that the Department of Veterans Affairs (VA) ask the Institute of Medicine (IOM) to convene a committee that would identify a method for assessing treatment effectiveness and describe already-validated treatments for Gulf War veterans' health problems, including the problem of medically unexplained symptoms. The specific charge to the committee is to (1) identify and describe approaches for assessing treatment effectiveness; (2) identify illnesses and conditions among veterans of the Gulf War, using data obtained from the VA and the Department of Defense (DoD) Gulf War Registries, as well as information in published articles; and (3) for these identified conditions and illnesses, identify validated models of treatment (to the extent that such treatments exist), or identify new approaches, theories, or research on the management of patients with these conditions if validated treatment models are not available.

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