References

Aboody, K.S., Brown, A., Rainov, N.G., Bower, K.A., Liu, Shaoxiong, Yang, W., Small, J.E., Herrlinger, U., Ourednik, V., Black, P.M., Breakefield, X.O., and Snyder, E.Y. (2000). Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas. Proc Natl Acad Sci USA 97(23):12846-51.


Beattie, G.M., Otonkoski, T., Lopez, A.D., and Hayek, A. (1997). Functional beta-cell mass after transplantation of human fetal pancreatic cells: differentiation or proliferation? Diabetes 46:244-8.

Bhardwaj, G., Murdoch, B., Wu, D., Baker, D.P., Williams, K.P., Chadwick, K., Ling, L.E., Karanu, F.N., Bhatia, M. (2001). Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation. Nat Immunol 2:172-80.

Bittner, R.E., Schofer, C., Weipoltshammer, K., Ivanova, S., Streubel, B., Hauser, E., Freilinger, M., Hoger, H., Elbe-Burger, A., and Wacthler, F. (1999). Recruitment of bone-marrow-derived cells by skeletal and cardiac muscle in adult dystrophic mdx mice. Anat Embryol (Berl) 199:391-6.

Bjornson, C.R., Rietze, R.L., Reynolds, B.A., Magli, M.C., and Vecovi, A.L. (1999). Turning brain into blood: a hematopoietic fate adopted by adult neural stem cells in vivo. Science 283:534-7.

Blau, H.M., Brazelton, T.R., and Weimann, J.M. (2001). The evolving concept of a stem cell: entity or function? Cell 105:829-41.

Brazelton, T.R., Rossi, F.M., Keshet, G.I., and Blau, H.M. (2000). From marrow to brain: expression of neuronal phenotypes in adult mice. Science 290:1775-9.

Brustle, O., Choudhary, K., Karram, K., Huttner, A., Murray, K., Dubois, D.M., and McKay, R.D. (1998). Chimeric brains generated by intraventricular transplantation of human brain cells into embryonic rats. Nat Biotechnol 16 (11):1040-4.


Cashman, J.D. and Eaves, C.J. (2000). High marrow seeding efficiency of human lymphomyeloid repopulating cells in irradiated NOD/SCID mice. Blood 96:3979-81.

Chen J., Li, Y., Wang, L., Zhang, Z., Lu, D., Lu, M., and Chopp, M. (2001) Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats. Stroke 32:1005-1.

Clarke, D.L., Johansson, C.B., Wilbertz, J., Veress, B., Nilsson, E., Karlstrom, H., Lendahl, U., and Frisen, J. (2000). Generalized potential of adult neural stem cells. Science 288:1660-3.



The National Academies | 500 Fifth St. N.W. | Washington, D.C. 20001
Copyright © National Academy of Sciences. All rights reserved.
Terms of Use and Privacy Statement



Below are the first 10 and last 10 pages of uncorrected machine-read text (when available) of this chapter, followed by the top 30 algorithmically extracted key phrases from the chapter as a whole.
Intended to provide our own search engines and external engines with highly rich, chapter-representative searchable text on the opening pages of each chapter. Because it is UNCORRECTED material, please consider the following text as a useful but insufficient proxy for the authoritative book pages.

Do not use for reproduction, copying, pasting, or reading; exclusively for search engines.

OCR for page 61
Stem Cells and the Future of Regenerative Medicine References Aboody, K.S., Brown, A., Rainov, N.G., Bower, K.A., Liu, Shaoxiong, Yang, W., Small, J.E., Herrlinger, U., Ourednik, V., Black, P.M., Breakefield, X.O., and Snyder, E.Y. (2000). Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas. Proc Natl Acad Sci USA 97(23):12846-51. Beattie, G.M., Otonkoski, T., Lopez, A.D., and Hayek, A. (1997). Functional beta-cell mass after transplantation of human fetal pancreatic cells: differentiation or proliferation? Diabetes 46:244-8. Bhardwaj, G., Murdoch, B., Wu, D., Baker, D.P., Williams, K.P., Chadwick, K., Ling, L.E., Karanu, F.N., Bhatia, M. (2001). Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation. Nat Immunol 2:172-80. Bittner, R.E., Schofer, C., Weipoltshammer, K., Ivanova, S., Streubel, B., Hauser, E., Freilinger, M., Hoger, H., Elbe-Burger, A., and Wacthler, F. (1999). Recruitment of bone-marrow-derived cells by skeletal and cardiac muscle in adult dystrophic mdx mice. Anat Embryol (Berl) 199:391-6. Bjornson, C.R., Rietze, R.L., Reynolds, B.A., Magli, M.C., and Vecovi, A.L. (1999). Turning brain into blood: a hematopoietic fate adopted by adult neural stem cells in vivo. Science 283:534-7. Blau, H.M., Brazelton, T.R., and Weimann, J.M. (2001). The evolving concept of a stem cell: entity or function? Cell 105:829-41. Brazelton, T.R., Rossi, F.M., Keshet, G.I., and Blau, H.M. (2000). From marrow to brain: expression of neuronal phenotypes in adult mice. Science 290:1775-9. Brustle, O., Choudhary, K., Karram, K., Huttner, A., Murray, K., Dubois, D.M., and McKay, R.D. (1998). Chimeric brains generated by intraventricular transplantation of human brain cells into embryonic rats. Nat Biotechnol 16 (11):1040-4. Cashman, J.D. and Eaves, C.J. (2000). High marrow seeding efficiency of human lymphomyeloid repopulating cells in irradiated NOD/SCID mice. Blood 96:3979-81. Chen J., Li, Y., Wang, L., Zhang, Z., Lu, D., Lu, M., and Chopp, M. (2001) Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats. Stroke 32:1005-1. Clarke, D.L., Johansson, C.B., Wilbertz, J., Veress, B., Nilsson, E., Karlstrom, H., Lendahl, U., and Frisen, J. (2000). Generalized potential of adult neural stem cells. Science 288:1660-3.

OCR for page 61
Stem Cells and the Future of Regenerative Medicine Colter, D.C., Class, R., DiGirolamo, C.M., and Prockop, D.J. (2000). Rapid expansion of recycling stem cells in cultures of plastic-adherent cells from human bone marrow. Proc Natl Acad Sci USA 97:3213-8. Duncan, S.A., Navas, M.A., Dufor, D., Rossant, J., and Stoffel, M. (1998). Regulation of a transcription factor network required for differentiation and metabolism. Science 281: 692-5. Ema, H., Takano, H., Sudo, K., and Nakauchi, H. (2000). In vitro self-renewal division of hematopoietic stem cells. J Exp Med 192:1281-8. Ferrari, G., Cusella-DeAngelis, G., Coletta, M., Paolucci, E., Stornaiuolo, A., Cossu, G., and Mavilio, F. (1998). Muscle regeneration by bone marrow-derived myogenic progenitors. Science 279:1528-30. Gilmore, G.L., DePasquale, D.K., Lister, J., and Shadduck, R.K. (2000). Ex vivo expansion of human umbilical cord blood and peripheral blood CD34(+) hematopoietic stem cells. Exp Hematol 28:1297-1305. Gluckman, E., Rocha, V., and Chevret, S. (2001). Results of unrelated umbilical cord blood hematopoietic stem cell transplant. Transfus Clin Biol 8(3):146-54. Gulbrandsen, C.E. August 1, 2001, Testimony to the US Senate Subcommittee on Labor, Health, Human Services, Education, and Related agencies, Committee on Appropriations. Washington, D.C. Gussoni, E., Soneoka, Y., Stickland, C.D., Buzney, E.A., Khan, M.K., Fline, A.F., Kunkel, L.M., and Mulligan, R.C. (1999). Dystrophin expression in the mdx mouse restored by stem cell transplantation. Nature 401:390-4. Institute of Medicine. (1995). Society’s choices: social and ethical decision making in biomedicine. Washington, D.C.: National Academy Press. Institute of Medicine. (1998). Scientific opportunities and public needs: improving priority setting and public input at the National Institutes of Health. Washington, D.C.: National Academy Press. Itskovitz-Eldor, J., Schulding M., Karesenti, D., Eden., A., Yanuka, O., Amit, M., Soreq, H., and Benvenisty, N. (2000). Differentiation of human embryonic stem cells into embryoid bodies comprising the three embryonic germ layers. Mole Med 5:88-95. Jackson K.A., Majka, S.M., Wang, H., Pocius, J., Hartley, C.J., Majesky, M.W., Entman, M.L., Michael, L.H., Hirschi, K.K., and Goodell, M.A. (2001). Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. J Clin Invest 107:1395-1402. Kaufman, D.S., Lewis, R.L., Auerbach, R., et al. (1999). Directed differentiation of human embryonic stem cells into hematopoeitic colony forming cells. Blood 94 (supplement 1, part 1 of 2):34a. Kocher, A.A., Schuster, M.D., Szabolcs, M.J., Takuma, S., Burkhoff, D., Wang, J., Homma, S., Edwards, N.M., and Itescu, S. (2001). Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat Med 7:430-6. Kondo, T., and Raff, M. (2000). Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cells. Science 289(5485):1754-7. Krause, D.S., Theise, N.D., Collector, M.I., Henegariu, O., Hwang, S., Gardner, R., Neutzel, S., and Sharkis, S.J. (2001). Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 105:369-77. Kunkel, T.A., and Bebenek, K. (2000). DNA replication fidelity. Annu Rev Biochem 69:497-529. Lagasse, E., Connors, H., Al-Dhalimy, M., Reitsma, M., Dohse, M., Osborne, L., Wang, X., Finegold, M., Weissman, I.L., and Grompe, M. (2000). Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med 6:1229-34.

OCR for page 61
Stem Cells and the Future of Regenerative Medicine Laughlin, M.J. (2001). Umbilical cord blood for allogeneic transplantation in children and adults. Bone Marrow Transpl 27:1-6. Laughlin, M.J., Barker, J., Bambach, B., Koc, O.N., Rizzieri, D.A., Wagner, J.E., Gerson, S.L., Lazarus, H.M., Cairo, M., Stevens, C.E., Rubinstein, P., and Kurtzberg, J. (2001). Hematopoietic engraftment and survival in adult recipients of umbilical-cord blood from unrelated donors. New Eng J Med 344:1815-22. Li, M. Pevny, L., Lovell-Badge, R., and Snith, A. (1998). Generation of purified neural precursors from embryonic stem cells by lineage selection. Curr Biol 8:971-4. Lumelsky, N., Blondel, O., Laeng, P., Velasco, I., Ravin, R., and McKay, R. (2001). Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science 292:1389-94. McDonald, J.W., Liu, X.Z., Qu Y Liu, S., Mickey, S.K., Turetsky, D., Gottlieb,D.I., and Choi, D.W. (1999) Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord. Nat Med 5:1410-2. Mezey, E., Chandross, K.J., Harta, G., Maki, R.A., and McKercher, S.R. (2000). Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science 290:1779-82. Moore, K.A., Ema H., and Lemischka, I.R. (1997). In vitro maintenance of highly purified, transplantable hematopoietic stem cells. Blood 89:4337-47. Morrison, S.J. (2001). Neuronal differentiation: proneural genes inhibit gliogenesis. Curr Bio 11:R349-51. Nathan, D.G., Fontanarosa, P.B., and Wilson, J.D. (2001). Opportunities for medical research in the 21st century. JAMA 285(5):533-4. National Bioethics Advisory Commission. (1999). Ethical issues in human stem cell research, volume III, Religious Perspectives. Rockville, Md.: National Bioethics Advisory Commission. National Institutes of Health. (July 2001). Stem cells: scientific progress and future research directions, p 46. http://www.nih.gov/news/stemcell/scireport.htm. National Research Council. (2001). Trends in federal support of research and graduate education. Washington, D.C.: National Academy Press. Negrin, R.S., Atkinson, K., Leemhuis, T., Hanania, E., Juttner, C., Tierney, K., Hu, W.W., Johnston, L.J., Shizuru J.A., Stockerl-Goldstein, K.E., Blume, K.G., Weissman, I.L., Bower S., Baynes, R., Dansey, R., Karanes, C., Peters, W., and Klein, J. (2000). Transplantation of highly purified CD32+Thy-1+ hematopoietic stem cells in patients with metastatic breast cancer. Biol Blood Marrow Transpl 6:262-71. Noble, M. (2000). Can neural stem cells be used to track down and destroy migratory brain tumor cells while also providing a means of repairing tumor-associated damage? Proc Natl Acad Sci USA 97(23):12393-5. Noonan, J.T. (1970). An almost absolute value in history, pp. 1-59. In Noonan, J.T., editor, The morality of abortion — legal and historical perspectives. Cambridge, Mass.: Harvard University Press. Odorico, J.S., Kaufman, D.S., and Thomson, J.A. (2001). Multilineage differentiation from human embryonic stem cell lines. Stem Cells 19:193-204. Orlic D., Kajstura, J., Chimenti, S. Jakoniuk, I., Anderson, S.M., Li, B. Pickel, J., McKay, R., Nadal-Ginard, B., Bodine, D.M., Leri, A., and Anversa, P. (2001). Bone marrow cells regenerate infarcted myocardium. Nature 410:701-5. Palmer, T.D., Schwartz, P.H., Taupin, P., Kaspar, B., Stein, S.A., and Gage, F.H. (2001). Cell culture: progenitor cells from human brain after death. Nature 411(6833):42-3. Perry, D. (2000). Patients’ voices: the powerful sound in the stem cell debate. Science 287:1423.

OCR for page 61
Stem Cells and the Future of Regenerative Medicine Phillips, R.L., Ernst, R.E., Brunk, B., Ivanova, N., Mahan, M.A., Deanehan, J.K. , Moore, K.A., Overton, G.C., and Lemischka, I.R. (2000). The genetic program of hematopoietic stems cells. Science 288(5471):1635-40. Ramiya, V.K., Maraist, M., Arfors, K.E., Schatz, D.A., Peck, A.B., and Cornelius, J.G. (2000). Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells. Nat Med 6:278-82. Reubinoff, B.E., Per, M.F., Fong, C.Y., Trounson, A., and Bongso, A. (2000). Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro. [published erratum, Nat Biotechno 2000; 18:559.] Nat Biotechno 18:299-404. Saito, Y., Uzuka, Y., Sakai, N., Suzuki, S., and Toyota, T. (2000). Bone marrow transplant 25(11):1209-11. Sawamoto K, Nakao N, Kakishita K, Ogawa Y, Toyama Y, Yamamoto A, Yamaguchi M, Mori K, Goldman SA, Itakura T, and Okano H. (2001). Generation of dopaminergic neurons in the adult brain from mesencephalic precursor cells labeled with a nestin-GFP transgene. J Neurosci 21:3895-3903. Schuldiner, M., Yanuka, O., Istkovitz-Eldor, J. Melton, D., and Benvenistry, N. (2000). Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells. Proc Natl Acad Sci USA 907:11307-12. Shamblott, M.J., Axelman, J., Wang S., Bugg, E.M., Littlefield, J.W., Donovan, P.J., Blumenthal, P.D., Huggins, G.R., and Gearhart, J.D. (1998). Derivation of pluripotent stem cells from cultured human primordial germ cells. Proc Natl Acad Sci wS.A. 95:13726-31. Shizuru, J.A., Jerabeck, L., Edwards, C.T., and Weissman, I.L. (1996). Biol Blood Marrow Transpl 2:3. Studer, L., Tabar, V., and Mckay, R.D.G. (1998). Transplantation of expanded mesencephalic precursors leads to recovery in Parkinsonian rats. Nat Neurosci 1:290-5. Taniguchi, H., Toyoshima, T., Fukau, K., and Nakauchi, H. (1996). Presence of hematopoietic stem cells in the adult liver. Nat Med 2:198-203. Theise, N.D., Nimmakayalu, M., Gardner, R., Illei, P.B., Morgan, G., Teperman, L., Henegariu, O., and Krause, D.S. (2001). Liver from bone marrow in humans. Hepatology 32:11-16. Thomas, E.D., and Blume, K.G. (1999). Historical markers in the development of allogeneic hematopoietic cell transplantation. Biol Blood Marrow Transpl 5:341-6. Thomson, J.A., Itskovitz-Eldor, J., Shapiro, S.S., Waknitz, M.A., Swiergiel, J.J., Marshall, V.S., and Jones, J.M. (1998). Embryonic stem cell lines derived from human blastocysts. Science 282:1145-7. Till, J.E., and McCullough, E.A. (1961). A direct measurement of the radiation sensitivity of normal mouse bone marrow cells. Radiat Res 14:213-22. Torrente Y, Tremblay, J.P., Pisati, F., Belicchi, M., Rossi, B., Sironi, M., Fortunato, F., El Fahime, M., D’Angelo, M.G., Caron, N.J., Constantin, G., Paulin, D., Scarlato, G., and Bresolin, N. (2001). Intraarterial injection of muscle-derived CD34+Sca-1+ stem cells restores dystrophin in mdx mice. J Cell Biol 152:335-48. Torres, M. (1998). The use of embryonic stem cells for the genetic manipulation of the mouse. Curr Top Dev Biol 36:99-114. Uchida, N., Tsukamoto, A., He, D., Friera, A.M., Scollay, R., and Weissman, I.L. (1998). High doses of purified stem cells cause early hematopoietic recovery in syngeneic and allogeneic hosts. J Clin Invest 101:961-6. Villa A., Snyder, E.Y., Vescovi, A., and Martinez-Serrano, A. (2000) Establishment and properties of a growth factor-dependent perpetual neural stem cell line from the human CNS. Exp Neurol 161(1):67-84.

OCR for page 61
Stem Cells and the Future of Regenerative Medicine Wang, J.S., Shum-Tim, D., Galipeau, J., Chedrawy, E., Eliopoulos, N., and Chiu Ray, C.J. (2000). Marrow stromal cells for cellular cardiomyoplasty: feasibility and potential clinical advantages. J Thorac Cardiovasc Surg 120:999-1006. Wobus, A.M., and Boheler, K.R. (1999). Embryonic stem cells as a developmental model in vitro. Cells Tissues Organs 165:3-4. Zuk, P.A., Zhu, M., Mizuno, H., Huang, J., Futrell, J.W., Katz, A.J., Benhaim, P., Lorenz, P., and Hedrick, M.H. (2001). Multilineage cells from human adipose tissue: implications for cell-based therapies. Tiss Eng 7(2):211-28.

OCR for page 61
Stem Cells and the Future of Regenerative Medicine This page in the original is blank.