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Stem Cells and the Future of Regenerative Medicine
Marcus Grompe, MD, PhD, is a pediatrician in the Department of Molecular and Medical Genetics, Oregon Health Sciences University. Using a mouse model of hereditary tyrosinemia (a genetic disease that is associated with severe liver deficiency in infants), his laboratory has found that more than 90% of host hepatocytes can be replaced by a small number of transplanted donor cells in a process called “therapeutic liver repopulation,” which is analogous to repopulation of the hematopoietic system after bone marrow transplantation.
Ihor Lemischka, PhD, is professor in the Department of Genetics, Genomics, and Bioinformatics at Princeton University. His research analyzes hemopoietic differentiation using retroviruses as markers and has focused on gaining insight into the in vivo clonal behavior of the most primitive fetal liver or adult bone marrow hematopoietic stem cells. In particular, his laboratory is interested in understanding the mechanistic aspects of: (1) self-renewal vs. commitment decisions during stem cell proliferation and (2) the nature of commitment decisions as they partition the complete set of developmental potential into subsets or, in other words, the establishment of the primitive portion of the hematopoietic hierarchy.
Olle Lindvall, MD, PhD, is professor of neurology and chairman of the Department of Clinical Neuroscience, Lund University, Lund, Sweden. Dr. Lindvall’s current main research interests are the use of cell and gene therapy for preservation and restoration of function in acute and chronic brain diseases. Since 1983 he has been in charge of the clinical cell transplantation program for patients with Parkinson’s disease at Lund University.
Ron McKay, MD, is the chief of the Laboratory of Molecular Biology at the National Institute of Neurological Disorders and Stroke. Dr. McKay has made major contributions to the identification of stem cells in the nervous system. His group is developing cell therapies for diabetes, neurological, and cardiac disease.