differentiation, 7, 19

embryonic, 32, 33

Brain

adult stem cells, 2, 12, 16, 23, 24, 25, 27-28

Alzheimer’s disease, 8

committee workshop agenda, 80

embryonic stem cells, 32, 38

fetal stem cells, 13

Parkinson’s disease, 8, 13, 27, 35, 84

Breast cancer, 22, 85

Burns, 8

C

Cancer, 8

see also Bone marrow stem cells

adult stem cells, 22, 24

brain, 24

breast, 22, 85

embryonic stem cells, 32, 34, 36, 38

hematopoietic stem cells, 22

neoplastic growth defined, 71

Cardiovascular system, 8

adult stem cells, 21, 28

embryonic stem cells, 32, 33

neural crest cells, 13

Cartilage, 16, 28, 33

Chromosomes, 32, 36

defined, 68

Cloning, reproductive, 10, 11, 47

D

Dendrites

defined, 68

embryonic stem cells, 38

Diabetes, 8, 16, 28, 35, 84

Differentiation, 1, 42, 55

see also Multipotent stem cells;

Plasticity

adult stem cells, 2, 7-8, 16-17, 20, 21, 27-28, 29

blood cells, 19, 20

bone marrow stem cells, 7, 19

defined, 68

embryonic stem cells, 7-8, 19, 21, 32-33, 34, 36-38

undifferentiated cells, defined, 72

Digestive system, 13, 21, 23, 33

DNA

defined, 68

recombinant, 3-4, 51-53, 58

Drugs, immunosuppressive, 4, 34

E

Ectoderm, 13, 21

defined, 68

Embryonic germ cells, 16

defined, 68

Embryonic stem cells (ESCs), 8, 10, 15, 16, 31-39, 55, 86

see also Blastocysts;

Philosophical, ethical and legal issues

adult stem cells vs, 2-3, 17, 56

animal models, 32-34, 35, 36

bone marrow, 32, 33

brain, 32, 38

cancer, 32, 34, 36, 38

cardiovascular system, 32, 33

cloning vs, 11

committee recommendations, 5, 41-42, 43, 56

committee workshop agenda, 79-81

defined, 13, 68-69

differentiation, 7-8, 19, 21, 32-33, 34, 36-38

feeder cells, 33, 36

funding for research, 3-4, 5, 35, 49-51, 58, 59

hematopoietic, 32, 33, 34, 35, 47

hepatic, 34, 38

immune system, 34-35, 36, 38-39, 47

multipotent, 16, 32, 33-34, 41

muscle, 32, 33

neural stem cells, 8, 15, 32, 33-34, 35

pancreatic, 32, 34-35, 36

plasticity, 41;

see also “multipotent” supra

private sector, 3, 49-51

renal, 34-35

skin, 16, 33

Front Matter (R1-R18)

Executive Summary (1-6)

1. Project Overview and Definitions (7-18)

2. Adult Stem Cells (19-30)

3. Embryonic Stem Cells (31-40)

4. Opportunities for and Barriers to Progress in Stem Cell Research for Regenerative Medicine (41-54)

5. Findings and Recommendations (55-60)

References (61-66)

Glossary (67-72)

Appendix A: Committee Biographies (73-78)

Appendix B: Workshop Agenda and Speaker Biographies (79-88)

Index (89-94)