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Scientific and Medical of Aspects: Human Reproductive Cloning
TABLE 1 Rates of Success/Failure of Somatic Cell Nuclear Transfer in Mammals
1
2
3
4
5
6
Speciesa
Cell typeb
# Embryos producedc
# Embryos developed into morula/ blastocyst (%)d
# Fetuses after embryo transfere
# Fetuses miscarried (%)f
Sheep
Embryo-derived epithelial-like
244
34 (14)
8
3 (38)
Adult mammary gland
277
29 (12)
1
0 (0)
Fetal fibroblast
172
47 (27)
5
2 (40)
Embryo-derived epithelial-like
385
126 (33)
15
11 (73)
Fetal fibroblast
507
69 (13.6)
14
7 (50)
ES cell line-derived epithelial-like
128
31 (24.2)
>9
>7 (~78)
ES cell line-derived epithelial-like
258
44 (17)
>11
>10 (~91)
ES cell line-derived epithelial-like
423
75 (18)
8
5 (63)
ES cell line-derived fibroblast-like
158
39 (31)
10
7 (70)
ES cell line-derived fibroblast-like
187
51 (27)
15
8 (53)
Fetal fibroblast
417
80 (19)
20
6 (30)
Cattle
Blastomere (embryonic)
641
152 (24)
>13
>4 (~31)
Blastomere (embryonic)
132
84 (64)
N/A
N/A
Embryonic stem cell
239
42 (18)
N/A
N/A
Fetal fibroblast
276
33 (12)
6
2 (33)
Adult mural granulosa from 13 yr old cow
621
259 (42)
28
26 (93)
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