|
1
|
2
|
3
|
4
|
|
Speciesb
|
Cell typec
|
Defects seen in miscarried fetusesd
|
# Live birthse
|
|
Sheep
|
Embryo-derived epithelial-like
|
N/A
|
5
|
|
Adult mammary gland
|
N/A
|
1
|
|
Fetal fibroblast
|
2 fetuses from one of the cell types showed abnormal liver development
|
3
|
|
Embryo-derived epithelial-like
|
N/A
|
4
|
|
Fetal fibroblast
|
1 died after delayed delivery, 2 died after sibling (2) died in utero, 2 stillborn
|
7
|
|
ES cell line-derived epithelial-like injected into in vivo-matured oocytes
|
3 late aborted fetuses underdeveloped for age; edema, hydronephrosis, testicular hypoplasia; also fetuses had variety of other defects, including cleft palate and interventricular septal defect
|
2
|
|
ES cell line-derived epithelial-like injected into in vitro-matured oocytes
|
1 late aborted fetus underdeveloped for age; edema, hydronephrosis, testicular hypoplasia
|
1
|
|
ES cell line-derived epithelial like
|
N/A
|
3
|
|
ES cell line-derived fibroblast-like
|
N/A
|
3
|
|
ES cell line-derived fibroblast-like
|
N/A
|
7
|
|
Fetal fibroblast
|
N/A
|
14
|