TABLE 2 Phenotypes Observed in Cloned Animals

1

2

3

4

Speciesb

Cell typec

Defects seen in miscarried fetusesd

# Live birthse

Sheep

Embryo-derived epithelial-like

N/A

5

Adult mammary gland

N/A

1

Fetal fibroblast

2 fetuses from one of the cell types showed abnormal liver development

3

Embryo-derived epithelial-like

N/A

4

Fetal fibroblast

1 died after delayed delivery, 2 died after sibling (2) died in utero, 2 stillborn

7

ES cell line-derived epithelial-like injected into in vivo-matured oocytes

3 late aborted fetuses underdeveloped for age; edema, hydronephrosis, testicular hypoplasia; also fetuses had variety of other defects, including cleft palate and interventricular septal defect

2

ES cell line-derived epithelial-like injected into in vitro-matured oocytes

1 late aborted fetus underdeveloped for age; edema, hydronephrosis, testicular hypoplasia

1

ES cell line-derived epithelial like

N/A

3

ES cell line-derived fibroblast-like

N/A

3

ES cell line-derived fibroblast-like

N/A

7

Fetal fibroblast

N/A

14



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