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6
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7
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References
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Significant findings
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Campbell 1996
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Nuclei from cell lines from embryonic discs are able to support development to term.
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Robl 1987
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Cleavage stage embryonic nuclei are unable to direct embryonic or term development when transferred to enucleated zygotes.
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Prather 1987
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Term development from transcriptionally active donor embryonic nuclei.
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Bondioli 1990
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Nuclei from morula stage embryos can direct midgestation development.
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Chesne 1993
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Nuclei from morula stage embryos can direct development to term.
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Collas 1994
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Direct injection of inner cell mass nuclei into Mll cytoplasts can direct development to term.
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Keefer 1994
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Totipotency of inner cell mass nuclei confirmed.
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Sims 1984
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Nuclei from inner cell mass cultured for up to 28 days are able to direct development to term.
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Zakhartchenko 1999
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Fetal germ cells can direct development to term.
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Stice 1988
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First production of genetically verified nuclear transfer rabbits from embryonic donor nuclei.
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Prather 1989
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High rates of development from transcriptionally active embryonic nuclei.
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Collas 1990; Callas 1991
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Normal embryonic development from inner cell mass donor nuclei.
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Prather 1989
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Cleavage stage embryonic nuclei can direct term development in pigs.
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Yong 1998
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Serial nuclear transfer of transcriptionally nuclei results in high rates of development.
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Meng 1997
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Embryonic nuclei can support term development in the monkey.
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gKono T et al. Development of enucleated mouse oocytes reconstituted with embryonic nuclei. J. Reprod. Fertil. 1991; 93:165-72.
SOURCE: Lewis, IM, MJ Munsie, AJ French, R Daniels and AO Trounson, 2001. The Cloning Cycle: From Amphibia to Mammals and Back. Reproductive Medicine Reviews 9:1 pp. 3-33.
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