In summary, the major vaccine manufacturers will not be able to provide all of the needed biodefense vaccines. However, they should be asked to play a significant role. That role will be facilitated by clear directions, clear priority setting, and a tight collaboration between industry and government in order to move animal and clinical testing forward.


A. Johnson-Winegar:

Grabenstein, J.D., and Wilson, J.P. (1999), “Are Vaccines Safe? Risk Communication Applied to Vaccination,” Hospital Pharmacy, Vol.34, No. 6, pp. 713–729.

Institute of Medicine. (1996), Interaction of Drugs, Biologics, and Chemicals in U.S. Military Forces. Washington, D.C.: National Academy Press.

Morbidity and Mortality Weekly Report. (December 15, 2000), 49(RR15);1–20 “Use of Anthrax Vaccine in the United States—Recommendations of the Advisory Committee on Immunization Practices.”

G. Nabel:

Balter, M. 2000. Science 290: 923–925.

Colebunders R, Borchert M. 2000. Journal of Infections. 40: 16–20.

Malashkevich VN, Schneider BJ, McNally ML, Milhollen MA, Pang JX, Kim PS. 1999. Proceeding of the National Academy of Sciences, U S A 96:2662–2667.

Peters CJ, Sanchez A, Rollin PE, Ksiazek TG, Murphy FA. 1996. In: Fields BN, Knipe DM, Howley PM, eds. Fields Virology 1161–1176 (Lippincott-Raven, Philadelphia).

Peters CJ, Khan AS. 1999. In: Klenk, HD, ed. Current Topics in Microbiology and Immunology 235:85–95 (Springer-Verlag, Berlin).

Sanchez A, Khan AS, Zaki SR, Nabel GJ, Ksiazek TG, Peters CJ. 1996a. In: Fields BN, Knipe DM, Howley PM, eds. Fields Virology 1279–1304 (Lippincott-Raven, Philadelphia).

Sanchez A, Trappier SG, Mahy BWJ, Peters CJ, Nichol ST. 1996b. Proceedings of the National Academy of Sciences, USA 93: 3602–3607.

Sullivan NJ, Sanchez A, Rollin PE, Yang ZY, Nabel GJ. 2000. Nature 408: 605–609.

Volchkov VE, Becker S, Volchkova VA, Ternovoj VA, Kotov AN, Netesov SV, Klenk HD. 1995. Virology 214: 421–430.

Watanabe S, Takada A, Watanabe T, Ito H, Kida H, Kawaoka Y. 2000. Journal of Virology. 74: 10194–10201.

Weissenhorn W, Calder LJ, Wharton SA, Skehel JJ, Wiley DC. 1998a. Proceedings of the National Academy of Sciences, USA 95: 6032–6036.

Weissenhorn W, Carfi A, Lee KH, Skehel JJ, Wiley DC. 1998b. Molecular Cell. 5: 605–616. Xu L, Sanchez A, Yang Z, Zaki SR, Nabel EG, Nichol ST, Nabel GJ. 1998. Nature Medicine 4: 37–42.

Yang Z, Delgado R, Xu L, Todd RF, Nabel EG, Sanchez A, Nabel GJ. 1998. Science 279: 1034–1037.

Yang ZY, Duckers HJ, Sullivan NJ, Sanchez A, Nabel EG, Nabel GJ. 2000. Nature Medicine. 6: 886–889.

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