Appendix A
Biological Threats and Terrorism: How Prepared Are We? Assessing the Science and Our Response Capabilities

November 27–29, 2001

Lecture Room

National Academy of Sciences

2101 Constitution Avenue, NW

Washington, DC 20418

AGENDA

TUESDAY, NOVEMBER 27, 2001

8:30 am

Continental Breakfast

9:00

Welcome and Opening Remarks

Adel Mahmoud, Chair, Forum on Emerging Infections President, Merck Vaccines

Stanley Lemon, Vice-Chair, Forum on Emerging Infections Dean of Medicine, The University of Texas Branch at Galveston

9:15

Framing the Debate: Real-Time Considerations for Addressing Bioterrorism

Hon. William Frist, United States Senate

Anthony Fauci, National Institute of Allergy and Infectious Diseases

Edward Eitzen, U.S. Army Medical Research Institute of Infectious Diseases

James Hughes, Centers for Disease Control and Prevention

Michael Osterholm, University of Minnesota

Margaret Hamburg, Nuclear Threat Initiative



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Biological Threats and Terrorism: Assessing the Science and Response Capabilities - Workshop Summary Appendix A Biological Threats and Terrorism: How Prepared Are We? Assessing the Science and Our Response Capabilities November 27–29, 2001 Lecture Room National Academy of Sciences 2101 Constitution Avenue, NW Washington, DC 20418 AGENDA TUESDAY, NOVEMBER 27, 2001 8:30 am Continental Breakfast 9:00 Welcome and Opening Remarks Adel Mahmoud, Chair, Forum on Emerging Infections President, Merck Vaccines Stanley Lemon, Vice-Chair, Forum on Emerging Infections Dean of Medicine, The University of Texas Branch at Galveston 9:15 Framing the Debate: Real-Time Considerations for Addressing Bioterrorism Hon. William Frist, United States Senate Anthony Fauci, National Institute of Allergy and Infectious Diseases Edward Eitzen, U.S. Army Medical Research Institute of Infectious Diseases James Hughes, Centers for Disease Control and Prevention Michael Osterholm, University of Minnesota Margaret Hamburg, Nuclear Threat Initiative

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Biological Threats and Terrorism: Assessing the Science and Response Capabilities - Workshop Summary Session I: Assessing Our Understanding of the Threats Moderator: Joshua Lederberg, The Rockefeller University 10:15 Anthrax Arthur Friedlander, U.S. Army Medical Research Institute of Infectious Diseases 10:45 Smallpox Peter Jahrling, U.S. Army Medical Research Institute of Infectious Diseases 11:15 Tularemia and Plague David Dennis, NCID, Centers for Disease Control and Prevention 11:45 Botulinum Toxin Stephen Arnon, Infant Botulism Treatment and Prevention Program, California Department of Health Services 12:15 pm Innovative Surveillance Methods for Monitoring Dangerous Pathogens Patrick Kelley, Walter Reed Army Institute for Research 1:00 Lunch Session II: Vaccines: Development, Production, Supply, and Procurement Issues Moderator: Carole Heilman, National Institute of Allergy and Infectious Diseases 2:00 Vaccines for Threatening Agents: Ensuring the Availability of Countermeasures to Bioterrorism Philip Russell, Office of the Secretary, Department of Health and Human Services 2:30 The Department of Defense and the Development and Procurement of Vaccines Against Dangerous Pathogens: A Role in the Military and Civilian Sector? Anna Johnson-Winegar, Office of the Secretary of Defense, Chemical and Biological Matters

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Biological Threats and Terrorism: Assessing the Science and Response Capabilities - Workshop Summary 3:00 Applications of Modern Technology to Emerging Infections and Vaccine Development Gary Nabel, National Institute of Allergy and Infectious Diseases, Vaccine Research Center 3:30 Meeting the Regulatory and Product Development Challenges for Vaccines and Other Biologics to Address Terrorism Jesse Goodman, Center for Biologics Evaluation and Research, Food and Drug Administration Session III: Discussion Panel of Biological Threats and the Research Implications 4:30 Moderator: Adel Mahmoud, Merck Vaccines Donald Burke, Johns Hopkins University Stanley Plotkin, Aventis Pasteur Ken Alibek, Hadron, Inc. 6:30 Adjournment of the first day WEDNESDAY, NOVEMBER 28, 2001 8:00 am Continental Breakfast 8:30 Opening Remarks / Summary of Day 1 Stanley Lemon, Vice Chair, Forum on Emerging Infections Session IV: The Research Agenda and Emerging Technologies Moderator: Gail Cassell, Eli Lilly and Company 9:30 The Role of Antivirals C.J. Peters, University of Texas-Galveston 10:00 New Research in Antitoxins John Collier, Harvard Medical School 10:30 Recombinant Human Antibody: Immediate Immunity for Botulinum Neurotoxin and Other Class A Agents James Marks, University of California, San Francisco 11:00 Diagnostics and Detection Methods: Improving Rapid Response Capabilities David Relman, Stanford University

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Biological Threats and Terrorism: Assessing the Science and Response Capabilities - Workshop Summary 11:30 Meeting the Regulatory and Product Development Challenges for Drugs to Address Terrorism Andrea Meyerhoff, Office of the Commissioner, Food and Drug Administration 12:30 pm Q & A Session/Working Lunch Session V: The Response Infrastructure Moderator: Michael Osterholm, University of Minnesota 1:30 Lessons Being Learned: The Challenges and Opportunities Scott Lillibridge, Office of the Secretary, Department of Health and Human Services Julie Gerberding, Centers for Disease Control and Prevention Bradley Perkins, Centers for Disease Control and Prevention Kevin Yeskey, Centers for Disease Control and Prevention 3:00 The Progress, Priorities, and Concerns of Public Health Laboratories Mary Gilchrist, University Hygienic Laboratory, Iowa 3:30 Centers for Public Health Preparedness Stephen S. Morse, Mailman School of Public Health, Columbia University 4:00 The Role of Coordinated Information Dissemination: The CASCADE program in the United Kingdom John Simpson, Head of Emergency Planning Co-ordination Unit, Department of Health, UK 4:30 The Legal Infrastructure for an Effective Public Health Response David Fidler, Indiana University School of Law Session VI: Discussion Panel of the Spectrum of Research and Public Health Responses 5:00 Moderator: James Hughes, NCID, Centers for Disease Control and Prevention Michael Ascher, Office of the Secretary, Department of Health and Human Services Craig Watz, Federal Bureau of Investigation Donald Wetter, U.S. Public Health Service David Shlaes, Wyeth-Ayerst Research

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Biological Threats and Terrorism: Assessing the Science and Response Capabilities - Workshop Summary   Jerry Gibson, South Carolina Department of Health and Environmental Control Eric Eisenstadt, Defense Advanced Research Projects Agency Renu Gupta, Novartis 6:30 Closing Remarks /Adjournment Stanley Lemon, Vice-Chair, Forum on Emerging Infections THURSDAY, NOVEMBER 29, 2001 8:30 am Continental Breakfast 9:00 Opening Remarks Adel Mahmoud, Chair Stanley Lemon, Vice-Chair Priorities for the Next Steps in Countering Bioterrorism 9:15 am Panel Discussion Moderator: Fred Sparling, UNC-Chapel Hill Panelists: D.A. Henderson, Office of the Secretary, Department of Health and Human Services Ruth Berkelman, Emory University Scott Layne, UCLA Susan Maslanka, Centers for Disease Control and Prevention Kristi Koenig, Department of Veterans Affairs Tom Milne, National Association of County and City Health Officials Ronald Atlas, University of Louisville, President-Elect, American Society of Microbiology 11:15 Round-the-Table Discussion (Lunch will be served) 2:00 pm Closing Remarks/Adjournment