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Biological Threats and Terrorism: Assessing the Science and Response Capabilities: Workshop Summary (2002)

Chapter: Appendix L Forum Member, Speaker, and Staff Biographies

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Suggested Citation:"Appendix L Forum Member, Speaker, and Staff Biographies." Institute of Medicine. 2002. Biological Threats and Terrorism: Assessing the Science and Response Capabilities: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10290.
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Suggested Citation:"Appendix L Forum Member, Speaker, and Staff Biographies." Institute of Medicine. 2002. Biological Threats and Terrorism: Assessing the Science and Response Capabilities: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10290.
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Suggested Citation:"Appendix L Forum Member, Speaker, and Staff Biographies." Institute of Medicine. 2002. Biological Threats and Terrorism: Assessing the Science and Response Capabilities: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10290.
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Suggested Citation:"Appendix L Forum Member, Speaker, and Staff Biographies." Institute of Medicine. 2002. Biological Threats and Terrorism: Assessing the Science and Response Capabilities: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10290.
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Suggested Citation:"Appendix L Forum Member, Speaker, and Staff Biographies." Institute of Medicine. 2002. Biological Threats and Terrorism: Assessing the Science and Response Capabilities: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10290.
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Suggested Citation:"Appendix L Forum Member, Speaker, and Staff Biographies." Institute of Medicine. 2002. Biological Threats and Terrorism: Assessing the Science and Response Capabilities: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10290.
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Suggested Citation:"Appendix L Forum Member, Speaker, and Staff Biographies." Institute of Medicine. 2002. Biological Threats and Terrorism: Assessing the Science and Response Capabilities: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10290.
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Suggested Citation:"Appendix L Forum Member, Speaker, and Staff Biographies." Institute of Medicine. 2002. Biological Threats and Terrorism: Assessing the Science and Response Capabilities: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10290.
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Suggested Citation:"Appendix L Forum Member, Speaker, and Staff Biographies." Institute of Medicine. 2002. Biological Threats and Terrorism: Assessing the Science and Response Capabilities: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10290.
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Suggested Citation:"Appendix L Forum Member, Speaker, and Staff Biographies." Institute of Medicine. 2002. Biological Threats and Terrorism: Assessing the Science and Response Capabilities: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10290.
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Suggested Citation:"Appendix L Forum Member, Speaker, and Staff Biographies." Institute of Medicine. 2002. Biological Threats and Terrorism: Assessing the Science and Response Capabilities: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10290.
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Suggested Citation:"Appendix L Forum Member, Speaker, and Staff Biographies." Institute of Medicine. 2002. Biological Threats and Terrorism: Assessing the Science and Response Capabilities: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10290.
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Suggested Citation:"Appendix L Forum Member, Speaker, and Staff Biographies." Institute of Medicine. 2002. Biological Threats and Terrorism: Assessing the Science and Response Capabilities: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10290.
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Suggested Citation:"Appendix L Forum Member, Speaker, and Staff Biographies." Institute of Medicine. 2002. Biological Threats and Terrorism: Assessing the Science and Response Capabilities: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10290.
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Suggested Citation:"Appendix L Forum Member, Speaker, and Staff Biographies." Institute of Medicine. 2002. Biological Threats and Terrorism: Assessing the Science and Response Capabilities: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10290.
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Suggested Citation:"Appendix L Forum Member, Speaker, and Staff Biographies." Institute of Medicine. 2002. Biological Threats and Terrorism: Assessing the Science and Response Capabilities: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10290.
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Suggested Citation:"Appendix L Forum Member, Speaker, and Staff Biographies." Institute of Medicine. 2002. Biological Threats and Terrorism: Assessing the Science and Response Capabilities: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10290.
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Suggested Citation:"Appendix L Forum Member, Speaker, and Staff Biographies." Institute of Medicine. 2002. Biological Threats and Terrorism: Assessing the Science and Response Capabilities: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10290.
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Suggested Citation:"Appendix L Forum Member, Speaker, and Staff Biographies." Institute of Medicine. 2002. Biological Threats and Terrorism: Assessing the Science and Response Capabilities: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10290.
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Suggested Citation:"Appendix L Forum Member, Speaker, and Staff Biographies." Institute of Medicine. 2002. Biological Threats and Terrorism: Assessing the Science and Response Capabilities: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10290.
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Suggested Citation:"Appendix L Forum Member, Speaker, and Staff Biographies." Institute of Medicine. 2002. Biological Threats and Terrorism: Assessing the Science and Response Capabilities: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10290.
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Suggested Citation:"Appendix L Forum Member, Speaker, and Staff Biographies." Institute of Medicine. 2002. Biological Threats and Terrorism: Assessing the Science and Response Capabilities: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10290.
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Suggested Citation:"Appendix L Forum Member, Speaker, and Staff Biographies." Institute of Medicine. 2002. Biological Threats and Terrorism: Assessing the Science and Response Capabilities: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10290.
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Suggested Citation:"Appendix L Forum Member, Speaker, and Staff Biographies." Institute of Medicine. 2002. Biological Threats and Terrorism: Assessing the Science and Response Capabilities: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10290.
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Suggested Citation:"Appendix L Forum Member, Speaker, and Staff Biographies." Institute of Medicine. 2002. Biological Threats and Terrorism: Assessing the Science and Response Capabilities: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10290.
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Suggested Citation:"Appendix L Forum Member, Speaker, and Staff Biographies." Institute of Medicine. 2002. Biological Threats and Terrorism: Assessing the Science and Response Capabilities: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10290.
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Suggested Citation:"Appendix L Forum Member, Speaker, and Staff Biographies." Institute of Medicine. 2002. Biological Threats and Terrorism: Assessing the Science and Response Capabilities: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10290.
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Suggested Citation:"Appendix L Forum Member, Speaker, and Staff Biographies." Institute of Medicine. 2002. Biological Threats and Terrorism: Assessing the Science and Response Capabilities: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10290.
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Suggested Citation:"Appendix L Forum Member, Speaker, and Staff Biographies." Institute of Medicine. 2002. Biological Threats and Terrorism: Assessing the Science and Response Capabilities: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10290.
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Suggested Citation:"Appendix L Forum Member, Speaker, and Staff Biographies." Institute of Medicine. 2002. Biological Threats and Terrorism: Assessing the Science and Response Capabilities: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10290.
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Suggested Citation:"Appendix L Forum Member, Speaker, and Staff Biographies." Institute of Medicine. 2002. Biological Threats and Terrorism: Assessing the Science and Response Capabilities: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/10290.
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Appendix L Forum Member, Speaker, and Staff Biographies FORUM MEMBERS ADEL A.F. MAHMOUD, M.D., Ph.D., (chair), is President of Merck Vac- cines at Merck & Co., Inc. He formerly served Case Western Reserve University and University Hospitals of Cleveland as Chairman of Medicine and Physician- in-Chief from 1987 to 1998. Prior to that, Dr. Mahmoud held several positions, spanning 25 years, at the same institutions. Dr. Mahmoud and his colleagues conducted pioneering investigations on the biology and function of eosinophils. He prepared the first specific anti-eosinophil serum, which was used to define the role of these cells in host resistance to helminthic infections. Dr. Mahmoud also established clinical and laboratory investigations in several developing countries including Kenya, Egypt, and The Philippines to examine the determi- nants of infection and disease in schistosomiasis and other infectious agents. This work led to the development of innovative strategies to control those infec- tions, which has been adopted by the World Health Organization as selective population chemotherapy. In recent years, Dr. Mahmoud turned his attention to developing a comprehensive set of responses to the problems associated with emerging infections in the developing world. He was elected to membership of the American Society for Clinical Investigation in 1978, the Association of American Physicians in 1980 and the Institute of Medicine of the National Academy of Sciences in 1987. He received the Bailey K. Ashford Award of the American Society of Tropical Medicine and Hygiene in 1983, and the Squibb Award of the Infectious Diseases Society of America in 1984. Dr. Mahmoud currently serves as Chair of the Forum on Emerging Infections and is a member 287

288 BIOLOGICAL THREATS AND TERRORISM of the Board on Global Health, both of the Institute of Medicine. He also chairs the U.S. Delegation to the U.S.-Japan Cooperative Medical Science Program. STANLEY M. LEMON, M.D., (vice-chair), is Dean of the School of Medicine at the University of Texas Medical Branch at Galveston. He received his under- graduate degree in biochemical sciences from Princeton University summa cum laude, and his M.D. with honor from the University of Rochester. He completed postgraduate training in internal medicine and infectious diseases at the Univer- sity of North Carolina at Chapel Hill, and is board certified in both. From 1977 to 1983, he served with the U.S. Army Medical Research and Development Command, directing the Hepatitis Laboratory at the Walter Reed Army Institute of Research. He joined the faculty of the University of North Carolina School of Medicine in 1983, serving first as Chief of the Division of Infectious Diseases, and then Vice Chair for Research of the Department of Medicine. In 1997, Dr. Lemon moved to the University of Texas Medical Branch as Professor and Chair of the Department of Microbiology & Immunology. He was subsequently appointed Dean pro tem of the School of Medicine in 1999, and permanent Dean of Medicine in 2000. Dr. Lemon’s research interests relate to the molecular vi- rology and pathogenesis of the positive-stranded RNA viruses responsible for hepatitis C and hepatitis A. He is particularly interested in the molecular mecha- nisms controlling cap-independent viral translation, and the replication of these RNA genomes. He has published over 180 papers, and numerous textbook chapters related to hepatitis and other viral infections, and has a longstanding interest in vaccine development. He has served previously as chair of the Anti- Infective Drugs Advisory Committee and the Vaccines and Related Biologics Advisory Committee of the U.S. Food and Drug Administration, and is past chair of the Steering Committee on Hepatitis and Poliomyelitis of the World Health Organization’s Programme on Vaccine Development. He presently serves as Chairman of the U.S. Hepatitis Panel of the U.S.-Japan Cooperative Medical Sciences Program, and chairs an Institute of Medicine study committee related to vaccines for the protection of the military against naturally occurring infectious disease threats. STEVEN J. BRICKNER, Ph.D., is Research Advisor, Antibacterials Chemis- try, at Pfizer Global Research and Development. He received his Ph.D. in or- ganic chemistry from Cornell University and was a NIH Postdoctoral Research Fellow at the University of Wisconsin-Madison. Dr. Brickner is a medicinal chemist with nearly 20 years of research experience in the pharmaceutical in- dustry, all focused on the discovery and development of novel antibacterial agents. He is an inventor/co-inventor on 21 U.S. patents, and has published nu- merous scientific papers, primarily within the area of the oxazolidinones. Prior to joining Pfizer in 1996, he led a team at Pharmacia and Upjohn that discovered

APPENDIX L: BIOGRAPHIES 289 and developed linezolid, the first member of a new class of antibiotics to be ap- proved in the last 35 years. GAIL H. CASSELL, Ph.D., is Vice President, Infectious Diseases Research, Drug Discovery Research, and Clinical Investigation at Eli Lilly & Company. Previously, she was the Charles H. McCauley Professor and (since 1987) Chair, Department of Microbiology, University of Alabama Schools of Medicine and Dentistry at Birmingham, a department which, under her leadership, has ranked first in research funding from the National Institutes of Health since 1989. She is a member of the Director’s Advisory Committee of the Centers for Disease Control and Prevention. Dr. Cassell is past president of the American Society for Microbiology (ASM) and is serving her third three-year term as chairman of the Public and Scientific Affairs Board of ASM. She is a former member of the Na- tional Institutes of Health Director’s Advisory Committee and a former member of the Advisory Council of the National Institute of Allergy and Infectious Dis- eases. She has also served as an advisor on infectious diseases and indirect costs of research to the White House Office on Science and Technology and was pre- viously chair of the Board of Scientific Counselors of the National Center for Infectious Diseases, Centers for Disease Control and Prevention. Dr. Cassell served eight years on the Bacteriology-Mycology-II Study Section and served as its chair for three years. She serves on the editorial boards of several prestigious scientific journals and has authored over 275 articles and book chapters. She has been intimately involved in the establishment of science policy and legislation related to biomedical research and public health. Dr. Cassell has received sev- eral national and international awards and an honorary degree for her research on infectious diseases. GORDON DEFRIESE, Ph.D., is Professor of Social Medicine and Professor of Medicine (in the Division of General Medicine and Clinical Epidemiology) at the UNC-CH School of Medicine. In addition, he holds appointments as Professor of Epidemiology and Health Policy and Administration in the UNC-CH School of Public Health and as Professor of Dental Ecology in the UNC-CH School of Dentistry. From 1986–2000, he served as Co-Director of the Robert Wood John- son Clinical Scholars Program, co-sponsored by the UNC-CH School of Medi- cine and the Cecil G. Sheps Center for Health Services Research. He received his Ph.D. from the University of Kentucky College of Medicine. Some of his re- search interests are in the areas of health promotion and disease prevention, medical sociology, primary health care, rural health care, cost-benefit analysis, and cost-effectiveness. He is a past president of the Association for Health Serv- ices Research and a fellow of the New York Academy of Medicine. He is foun- der of the Partnership for Prevention, a coalition of private-sector business and industry organizations, voluntary health organizations, and state and federal pub- lic health agencies based in Washington, D.C. that have joined together to work toward the elevation of disease prevention among the nation’s health policy pri-

290 BIOLOGICAL THREATS AND TERRORISM orities. He is an at-large member of the National Board of Medical Examiners. Since 1994 he has served as President and CEO of the North Carolina Institute of Medicine. He is Editor-in-Chief and Publisher of the North Carolina Medical Journal. CEDRIC E. DUMONT, M.D., is Medical Director for the Office of Medical Services (MED) at the U.S. Department of State. Dr. Dumont graduated from Columbia University with a B.A. in 1975 and obtained his medical degree from Tufts University School of Medicine in 1980. Dr. Dumont is a board-certified internist with subspecialty training in infectious diseases. He completed his in- ternal medicine residency in 1983 and infectious diseases fellowship in 1988 at Georgetown University Hospital in Washington, D.C. Dr. Dumont has been a medical practitioner for over 19 years, 2 of which included service in the Peace Corps. Since joining the Department of State in 1990, he has had substantial experience overseas in Dakar, Bamako, Kinshasa, and Brazzaville. For the past 3 years, as the Medical Director for the Department of State, Dr. Dumont has promoted the health of all United States Government employees serving over- seas by encouraging their participation in a comprehensive health maintenance program and by facilitating their access to high-quality medical care. Dr. Dumont is a very strong supporter of the professional development and ad- vancement of MED’s highly qualified professional staff. In addition, he has supported and encouraged the use of an electronic medical record, which will be able to monitor the health of all its beneficiaries, not only during a specific as- signment but also throughout their career in the Foreign Service. JESSE L. GOODMAN, M.D., M.P.H., was professor of medicine and Chief of Infectious Diseases at the University of Minnesota, and is now serving as Dep- uty Director for the U.S. Food and Drug Administration’s (FDA) Center for Biologics Evaluation and Research, where he is active in a broad range of scien- tific, public health, and policy issues. After joining the FDA commissioner’s office, he has worked closely with several centers and helped coordinate FDA’s response to the antimicrobial resistance problem. He was co-chair of a recently formed federal interagency task force which developed the national Public Health Action Plan on antimicrobial resistance. He graduated from Harvard College and attended the Albert Einstein College of Medicine followed by inter- nal medicine, hematology, oncology, and infectious diseases training at the Uni- versity of Pennsylvania and University of California Los Angeles, where he was also chief medical resident. He received his master’s of public health from the University of Minnesota. He has been active in community public health activi- ties, including creating an environmental health partnership in St. Paul, Minne- sota. In recent years, his laboratory’s research has focused on the molecular pathogenesis of tickborne diseases. His laboratory isolated the etiological intra- cellular agent of the emerging tickborne infection, human granulocytic ehrli-

APPENDIX L: BIOGRAPHIES 291 chiosis, and identified its leukocyte receptor. He has also been an active clini- cian and teacher and has directed or participated in major multi-center clinical studies. He is a Fellow of the Infectious Diseases Society of America and, among several honors, has been elected to the American Society for Clinical Investigation. RENU GUPTA, M.D., is Vice President and Head, U.S. Clinical Research and Development at Novartis Pharmaceuticals. Previously, she was Vice President, Medical, Safety, and Therapeutics at Covance. Dr. Gupta is a board certified Pediatrician, with subspeciality training in Infectious Diseases from Children’s Hospital of Philadelphia, and the University of Pennsylvania. She was also Postdoctoral Research Fellow in Microbiology at the University of Pennsylvania and the Wistar Institute of Anatomy and Biology, where she conducted research on the pathogenesis of infectious diseases. Dr. Gupta received her M.B.,Ch.B with distinction from the University of Zambia, where she examined the prob- lem of poor compliance in the treatment of tuberculosis in rural and urban Af- rica. She is currently active in a number of professional societies, including the Infectious Diseases Society of America and the American Society of Microbiol- ogy. She is a frequent presenter at the Interscience Conference on Antimicrobial Agents and Chemotherapy and other major congresses, and has been published in leading infectious diseases periodicals. From 1989 to mid-1998, Dr. Gupta was with Bristol-Myers Squibb Company, where she directed clinical research as well as strategic planning for the Infectious Diseases and Immunology Divi- sions. For the past several years, her work has focused on a better understanding of the problem of emerging infections. This has led to her pioneering efforts in establishing the Global Antimicrobial Surveillance Program, SENTRY, a pri- vate-academic-public sector partnership. Dr. Gupta chaired the steering com- mittee for the SENTRY Antimicrobial Surveillance Program. She remains active in women and children’s health issues, and is currently furthering education and outreach initiatives. More recently Dr. Gupta has been instrumental in the for- mation of the Harvard-Pharma Management Board, of which she is a member, to further the educational goals of the Scholars in Clinical Science Program at the Harvard Medical School. MARGARET A. HAMBURG, M.D., is Vice President for Biological Pro- grams, Nuclear Threat Initiative, Washington, D.C. The Nuclear Threat Initia- tive (NTI) is a new organization whose mission is to strengthen global security by reducing the risk of use of nuclear and other weapons of mass destruction and preventing their spread. Dr Hamburg is in charge of the biological program area. Before taking on her current position, Dr. Hamburg was the Assistant Secretary for Planning and Evaluation, U.S. Department of Health and Human Services, serving as a principal policy advisor to the Secretary of Health and Human Services with responsibilities including policy formulation and analysis, the

292 BIOLOGICAL THREATS AND TERRORISM development and review of regulations and/or legislation, budget analysis, stra- tegic planning, and the conduct and coordination of policy research and program evaluation. Prior to this, she served for almost six years as the Commissioner of Health for the City of New York. As chief health officer in the nation’s largest city, Dr. Hamburg’s many accomplishments included: the design and imple- mentation of an internationally recognized tuberculosis control program that produced dramatic declines in tuberculosis cases; the development of initiatives that raised childhood immunization rates to record levels; and the creation of the first public health bioterrorism preparedness program in the nation. She com- pleted her internship and residency in Internal Medicine at the New York Hos- pital/Cornell University Medical Center and is certified by the American Board of Internal Medicine. Dr. Hamburg is a graduate of Harvard College and Har- vard Medical School. She currently serves on the Harvard University Board of Overseers. She has been elected to membership in the Institute of Medicine, the New York Academy of Medicine, the Council on Foreign Relations, and is a Fellow of the American Association of the Advancement of Science. CAROLE A. HEILMAN, Ph.D., is Director of the Division of Microbiology and Infectious Diseases (DMID) of the National Institute of Allergy and Infec- tious Diseases (NIAID). Dr. Heilman received her bachelor’s degree in biology from Boston University in 1972, and earned her master’s degree and doctorate in microbiology from Rutgers University in 1976 and 1979. Dr. Heilman began her career at the National Institutes of Health as a postdoctoral research associ- ate with the National Cancer Institute where she carried out research on the regulation of gene expression during cancer development. In 1986, she came to NIAID as the influenza and viral respiratory diseases program officer in DMID and, in 1988, she was appointed chief of the respiratory diseases branch where she coordinated the development of acellular pertussis vaccines. She joined the Division of AIDS as deputy director in 1997 and was responsible for developing the Innovation Grant Program for Approaches in human immunodeficiency virus vaccine research. She is the recipient of several notable awards for outstanding achievement. Throughout her extramural career, Dr. Heilman has contributed articles on vaccine design and development to many scientific journals and has served as a consultant to the World Bank and the World Health Organization in this area. She is also a member of several professional societies, including the Infectious Diseases Society of America, the American Society for Microbiology, and the American Society of Virology. DAVID L. HEYMANN, M.D., is currently the Executive Director of the World Health Organization (WHO) Communicable Diseases Cluster. From October 1995 to July 1998 he was Director of the WHO Programme on Emerging and other Communicable Diseases Surveillance and Control. Prior to becoming di- rector of this programme, he was the chief of research activities in the Global

APPENDIX L: BIOGRAPHIES 293 Programme on AIDS. From 1976 to 1989 prior to joining WHO, Dr Heymann spent thirteen years working as a medical epidemiologist in sub-Saharan Africa (Cameroon, Cote d’ Ivoire, the former Zaire and Malawi) on assignment from the Centers for Disease Control and Prevention (CDC) in CDC-supported ac- tivities aimed at strengthening capacity in surveillance of infectious diseases and their control, with special emphasis on the childhood immunizable diseases, African haemorrhagic fevers, pox viruses, and malaria. While based in Africa, Dr Heymann participated in the investigation of the first outbreak of Ebola in Yambuku (former Zaire) in 1976, then again investigated the second outbreak of Ebola in 1977 in Tandala, and in 1995 directed the international response to the Ebola outbreak in Kikwit. Prior to 1976, Dr Heymann spent two years in India as a medical officer in the WHO Smallpox Eradication Programme. Dr Hey- mann holds a B.A. from the Pennsylvania State University, an M.D. from Wake Forest University, a Diploma in Tropical Medicine and Hygiene from the Lon- don School of Hygiene and Tropical Medicine, and completed practical epide- miology training in the Epidemic Intelligence Service (EIS) training program of the CDC. He has published 131 scientific articles on infectious diseases in peer- reviewed medical and scientific journals. JAMES M. HUGHES, M.D., received his B.A. in 1966 and M.D. in 1971 from Stanford University. He completed a residency in internal medicine at the Uni- versity of Washington and a fellowship in infectious diseases at the University of Virginia. He is board-certified in internal medicine, infectious diseases, and preventive medicine. He first joined CDC as an Epidemic Intelligence Service officer in 1973. During his CDC career, he has worked primarily in the areas of foodborne disease and infection control in healthcare settings. He became Di- rector of the National Center for Infectious Diseases in 1992. The center is cur- rently working to address domestic and global challenges posed by emerging infectious diseases and the threat of bioterrorism. He is a fellow of the American College of Physicians, the Infectious Diseases Society of America, and the American Association for the Advancement of Science. He is an Assistant Sur- geon General in the Public Health Service. SAMUEL L. KATZ, M.D., is Wilburt C. Davison Professor and chairman emeritus of pediatrics at Duke University Medical Center. He has concentrated his research on infectious diseases, focusing primarily on vaccine research, de- velopment and policy. Dr. Katz has served on a number of scientific advisory committees and is the recipient of many prestigious awards and honorary fel- lowships in international organizations. He attained his M.D. from Harvard Medical School and completed his residency training at Boston hospitals. He became a staff member at Children’s Hospital, working with Nobel laureate John Enders, during which time they developed the attenuated measles virus vaccine now used throughout the world. He has chaired the Committee on In- fectious Diseases of the American Academy of Pediatrics (the Redbook Com-

294 BIOLOGICAL THREATS AND TERRORISM mittee), the Advisory Committee on Immunization Practices (ACIP) of the Centers for Disease Control and Prevention, the Vaccine Priorities Study of the Institute of Medicine (IOM), and several World Health Organization (WHO) and Children’s Vaccine Initiative panels on vaccines. He is a member of many scientific advisory committees including those of the NIH, IOM, and WHO. Dr. Katz’s published studies include abundant original scientific articles, chapters in textbooks, and many abstracts, editorials, and reviews. He is the coeditor of a textbook on pediatric infectious diseases and has given many named lectures in the United States and abroad. Currently he co-chairs the Indo-US Vaccine Ac- tion Program as well as the National Network for Immunization Information (NNii). COLONEL PATRICK KELLEY, M.D., M.P.H., Dr.P.H., is Director of the Department of Defense Global Emerging Infections System and the Director of the Division of Preventive Medicine at the Walter Reed Army Institute of Re- search (WRAIR), Silver Spring, Maryland. He obtained his M.D. from the Uni- versity of Virginia and a Dr.P.H. in infectious disease epidemiology from the Johns Hopkins Bloomberg School of Public Health. He is board-certified in general preventive medicine and a fellow of the American College of Preventive Medicine. For many years he directed the Army General Preventive Medicine Residency at WRAIR. Colonel Kelley has extensive experience leading military infectious disease studies and in managing domestic and international public health surveillance efforts. He has spoken before professional audiences in over 15 countries and has authored or co-authored over 40 scientific papers and book chapters on a variety of infectious disease and preventive medicine topics. He serves as the specialty editor for a textbook entitled, Military Preventive Medi- cine: Mobilization and Deployment. MARCELLE LAYTON, M.D., is the Assistant Commissioner for the Bureau of Communicable Diseases at the New York City Department of Health. This bureau is responsible for the surveillance and control of 51 infectious diseases and conditions reportable under the New York City Health Code. Current areas of concern include antibiotic resistance; foodborne, waterborne, and tickborne diseases; hepatitis C and biological disaster planning for the potential threats of bioterrorism and pandemic influenza. Dr. Layton received her medical degree from Duke University. She completed an internal medicine residency at the University Health Science Center in Syracuse, New York, and an infectious dis- ease fellowship at Yale University. In addition, Dr. Layton spent two years with the Centers for Disease Control and Prevention as a fellow in the Epidemic In- telligence Service, where she was assigned to the New York City Department of Health. In the past, she has volunteered or worked with the Indian Health Serv- ice, the Alaskan Native Health Service, and clinics in northwestern Thailand and central Nepal.

APPENDIX L: BIOGRAPHIES 295 JOSHUA LEDERBERG, Ph.D., is Professor emeritus of Molecular Genetics and Informatics and Sackler Foundation Scholar at The Rockefeller University, New York, New York. His lifelong research, for which he received the Nobel Prize in 1958, has been in genetic structure and function in microorganisms. He has a keen interest in international health and was co-chair of a previous Institute of Medicine Committee on Emerging Microbial Threats to Health (1990–1992) and currently is co-chair of the Committee on Emerging Microbial Threats to Health in the 21st Century. He has been a member of the National Academy of Sciences since 1957 and is a charter member of the Institute of Medicine. CARLOS LOPEZ, Ph.D., is Research Fellow, Research Acquisitions, Eli Lilly Research Laboratories. He received his Ph.D. from the University of Minnesota in 1970. Dr. Lopez was awarded the NTRDA postdoctoral fellowship. After his fellowship he was appointed assistant professor of pathology at the University of Minnesota, where he did his research on cytomegalovirus infections in renal transplant recipients and the consequences of those infections. He was next ap- pointed assistant member and head of the Laboratory of Herpesvirus Infections at the Sloan Kettering Institute for Cancer Research, where his research focused on herpes virus infections and the resistance mechanisms involved. Dr. Lopez’s laboratory contributed to the immunological analysis of the earliest AIDS pa- tients at the beginning of the AIDS epidemic in New York. He is co-author of one of the seminal publications on this disease, as well as many scientific papers and co-editor of six books. Dr. Lopez has been a consultant to numerous agen- cies and organizations including the National Institutes of Health, the Depart- ment of Veterans Affairs, and the American Cancer Society. LYNN MARKS, M.D., is board certified in internal medicine and infectious diseases. He was on faculty at the University of South Alabama College of Medicine in the Infectious Diseases department focusing on patient care, teach- ing and research. His academic research interest was on the molecular genetics of bacterial pathogenicity. He subsequently joined SmithKline Beecham’s (now GlaxoSmithKline) anti-infectives clinical group and later progressed to global head of the Consumer Healthcare division Medical and Regulatory group. He then returned to pharmaceutical research and development as global head of the Infectious Diseases Therapeutic Area Strategy Team for GlaxoSmithKline. STEPHEN S. MORSE, Ph.D., is Director of the Center for Public Health Pre- paredness at the Mailman School of Public Health of Columbia University, and a faculty member in the Epidemiology Department. Dr. Morse recently returned to Columbia from 4 years in government service as Program Manager at the Defense Advanced Research Projects Agency (DARPA), where he co-directed the Pathogen Countermeasures program and subsequently directed the Ad-

296 BIOLOGICAL THREATS AND TERRORISM vanced Diagnostics program. Before coming to Columbia, he was Assistant Pro- fessor (Virology) at The Rockefeller University in New York, where he remains an adjunct faculty member. Dr. Morse is the editor of two books, Emerging Vi- ruses (Oxford University Press, 1993; paperback, 1996) (selected by “American Scientist” for its list of “100 Top Science Books of the 20th Century”), and The Evolutionary Biology of Viruses (Raven Press, 1994). He currently serves as a Section Editor of the CDC journal “Emerging Infectious Diseases” and was formerly an Editor-in-Chief of the Pasteur Institute’s journal “Research in Vi- rology”. Dr. Morse was Chair and principal organizer of the 1989 NIAID/NIH Conference on Emerging Viruses (for which he originated the term and concept of emerging viruses/infections); served as a member of the Institute of Medi- cine-National Academy of Sciences’ Committee on Emerging Microbial Threats to Health (and chaired its Task Force on Viruses), and was a contributor to its report, Emerging Infections (1992); was a member of the IOM’s Committee on Xenograft Transplantation; currently serves on the Steering Committee of the Institute of Medicine’s Forum on Emerging Infections, and has served as an adviser to WHO (World Health Organization), PAHO (Pan-American Health Organization), FDA, the Defense Threat Reduction Agency (DTRA), and other agencies. He is a Fellow of the New York Academy of Sciences and a past Chair of its Microbiology Section. He was the founding Chair of ProMED (the non- profit international Program to Monitor Emerging Diseases) and was one of the originators of ProMED-mail, an international network inaugurated by ProMED in 1994 for outbreak reporting and disease monitoring using the Internet. Dr. Morse received his Ph.D. from the University of Wisconsin-Madison. MICHAEL T. OSTERHOLM, Ph.D., M.P.H., is Director of the Center for Infectious Disease Research and Policy at the University of Minnesota where he is also Professor at the School of Public Health. Previously, Dr. Osterholm was the state epidemiologist and Chief of the Acute Disease Epidemiology Section for the Minnesota Department of Health. He has received numerous research awards from the National Institute of Allergy and Infectious Diseases and the Centers for Disease Control and Prevention (CDC). He served as principal in- vestigator for the CDC-sponsored Emerging Infections Program in Minnesota. He has published more than 240 articles and abstracts on various emerging in- fectious disease problems and is the author of the best selling book, Living Ter- rors: What America Needs to Know to Survive the Coming Bioterrorist Catas- trophe. He is past president of the Council of State and Territorial Epidemiologists. He currently serves on the National Academy of Sciences, Institute of Medicine (IOM) Forum on Emerging Infections. He has also served on the IOM Committee, Food Safety, Production to Consumption, the IOM Committee on the Department of Defense Persian Gulf Syndrome Comprehen- sive Clinical Evaluation Program and as a reviewer for the IOM report on chemical and biological terrorism.

APPENDIX L: BIOGRAPHIES 297 GARY A. ROSELLE, M.D., received his M.D. from Ohio State University School of Medicine in 1973. He served his residency at Northwestern University School of Medicine and his Infectious Diseases fellowship at the University of Cincinnati School of Medicine. Dr. Roselle is the Program Director for Infec- tious Diseases for VA Central Office in Washington, D.C., as well as the Chief of the Medical Service at the Cincinnati VA Medical Center. He is a professor of medicine in the Department of Internal Medicine, Division of Infectious Dis- eases at the University of Cincinnati College of Medicine. Dr. Roselle serves on several national advisory committees. In addition, he is currently heading the Emerging Pathogens Initiative for the Department of Veterans Affairs. Dr. Roselle has received commendations from the Cincinnati Medical Center Di- rector, the Under Secretary for Health for the Department of Veterans Affairs, and the Secretary of Veterans Affairs for his work in the infectious diseases pro- gram for the Department of Veterans Affairs. He has been an invited speaker at several national and international meetings, and has published over 80 papers and several book chapters. DAVID M. SHLAES, M.D., Ph.D., is Vice President and Therapeutic Area Co-Leader for Infectious Diseases at Wyeth. Before joining Wyeth, Dr. Shlaes was professor of medicine at the Case Western Reserve University School of Medicine and chief of the Infectious Diseases Section and the Clinical Microbi- ology Unit at the Veterans Affairs Medical Center in Cleveland, Ohio. His major research interest has been the mechanisms and epidemiology of antimicrobial resistance in bacteria where he has published widely. He has recently become more involved in the area of public policy as it relates to the discovery and de- velopment of antibiotics. He has served on the Institute of Medicine’s Forum on Emerging Infections since 1996. JANET SHOEMAKER, is director of the American Society for Microbiol- ogy’s Public Affairs Office, a position she has held since 1989. She is responsi- ble for managing the legislative and regulatory affairs of this 42,000-member organization, the largest single biological science society in the world. She has served as principal investigator for a project funded by the National Science Foundation (NSF) to collect and disseminate data on the job market for recent doctorates in microbiology and has played a key role in American Society for Microbiology (ASM) projects, including the production of the ASM Employ- ment Outlook in the Microbiological Sciences and The Impact of Managed Care and Health System Change on Clinical Microbiology. Previously, she held posi- tions as Assistant Director of Public Affairs for ASM, as ASM coordinator of the U.S./U.S.S.R. Exchange Program in Microbiology, a program sponsored and coordinated by the National Science Foundation and the U.S. Department of State, and as a freelance editor and writer. She received her baccalaureate, cum laude, from the University of Massachusetts, and is a graduate of the George

298 BIOLOGICAL THREATS AND TERRORISM Washington University programs in public policy and in editing and publica- tions. She has served as commissioner to the Commission on Professionals in Science and Technology, and as the ASM representative to the ad hoc Group for Medical Research Funding, and is a member of Women in Government Rela- tions, the American Society of Association Executives, and the American Asso- ciation for the Advancement of Science. She has co-authored published articles on research funding, biotechnology, biological weapons control, and public policy issues related to microbiology. P. FREDERICK SPARLING, M.D., is J. Herbert Bate Professor emeritus of Medicine, Microbiology and Immunology at the University of North Carolina (UNC) at Chapel Hill and is Director of the North Carolina Sexually Transmit- ted Infections Research Center. Previously, he served as chair of the Department of Medicine and chair of the Department of Microbiology and Immunology at UNC. He was president of the Infectious Disease Society of America in 1996–1997. He was also a member of the Institute of Medicine’s Committee on Microbial Threats to Health (1991–1992). Dr. Sparling’s laboratory research is in the molecular biology of bacterial outer membrane proteins involved in pathogenesis, with a major emphasis on gonococci and meningococci. His cur- rent studies focus on the biochemistry and genetics of iron-scavenging mecha- nisms used by gonococci and meningococci and the structure and function of the gonococcal porin proteins. He is pursuing the goal of a vaccine for gonorrhea. I. KAYE WACHSMUTH, Ph.D., serves as Deputy Administrator of the Office of Public Health and Science in USDA’s Food Safety and Inspection Service. Before joining USDA, she was the Deputy Director for Programs at the Food and Drug Administration’s Center for Food Safety and Applied Nutrition. Dr. Wachsmuth was with the Centers for Disease Control and Prevention in Atlanta from 1972–1994, where she was Deputy Director, Division of Bacterial and Mycotic Diseases from 1991–1994, and Chief, Enteric Diseases Laboratory Section from 1985–1991. While at CDC, she developed programs and con- ducted studies in the areas of molecular epidemiology and bacterial pathogene- sis. She also worked extensively in Southeast Asia and South America to estab- lish laboratory-based diarrheal disease surveillance programs. In addition to her positions at FDA and CDC, Dr. Wachsmuth chairs the National Advisory Committee on Microbiological Criteria for Foods and the Codex Committee for Food Hygiene, and is a member of the World Health Organization (WHO) Ex- pert Advisory Panel on Food Safety. She has been director of WHO’s Interna- tional Collaborating Center for Shigella. Through adjunct faculty appointments at the University of North Carolina School of Public Health, Emory University, and Georgia State University, Dr. Wachsmuth was doctoral research advisor to students in the microbial sciences. She also mentored postdoctoral students through the National Research Council, WHO, and Fogarty and Fulbright fel-

APPENDIX L: BIOGRAPHIES 299 lowship programs. At CDC in the early 1990s, she directed the summer research program for students enrolled in the University of Tuskegee Veterinary School and Morehouse University Medical School. Dr. Wachsmuth received her B.S. degree from Stetson University, Deland, Florida and Ph.D. degree in Microbiol- ogy from the University of Tennessee. She is a fellow of the Infectious Diseases Society of America and the American Academy of Microbiology. She has re- ceived awards for benchmark epidemiological investigations of Legionnaire’s disease, cholera in Latin America, drug-resistant tuberculosis, hantavirus in the western United States, and diphtheria in the former Soviet Union. Author of more than 160 scientific papers, she is on the editorial board of scientific jour- nals and is editor of a book on cholera. C. DOUGLAS WEBB, Jr., Ph.D., received his bachelor’s degree in biology from Emory University and his master’s and doctoral degrees in microbiology from the University of Georgia. He served in the Public Health Service at the Centers for Disease Control and Prevention (CDC) as both a research microbi- ologist and supervisory microbiologist. After the CDC, Dr. Webb went to Pfizer Pharmaceuticals and was involved in the development of ampicillin-sulbactam, carbenicillin, cefoperazone, fluconazole, azithromycin, and trovafloxacin. Dr. Webb is Senior Medical Director in Infectious Diseases in U.S. Medicines at Bristol-Myers Squibb, working on the strategy and development for the anti- infective portfolio. MICHAEL ZEILINGER, D.P.M, M.P.H., is Infectious Disease Team Leader at the Office of Health and Nutrition, Environmental Health Division at the U.S. Agency for International Development. Dr. Zeilinger serves as the senior advi- sor and manager of the infectious disease strategic objective team which encom- passes four sub-teams: malaria, tuberculosis, antimicrobial resistance, and sur- veillance. He is also the Cognizant Technical Officer for USAID’s umbrella Inter-Agency Agreement with the Centers for Disease Control and Prevention. Prior to his work at USAID/W, Dr. Zeilinger was the Program Director for Pro- ject HOPE in the Central Asian republics, which included public and private sector-funded TB control projects in Kazakhstan, Uzbekistan, Kyrgyzstan and Turkmenistan. His work in Central Asia also included humanitarian assistance and child survival programs. Prior to that, he worked with Birch and Davis on the Department of Defense’s Military Health Service System, and the Public Health Foundation on a U.S. Department of Health and Human Services funded Empowerment Zones/Enterprise Communities Health Benchmarks Demonstra- tion Project. Dr. Zeilinger is a Doctor of Podiatric Medicine and managed sev- eral community health programs during his surgical residency. He also has a master’s degree in public health (International Health Promotion) from George Washington University and is currently an Adjunct Professor at their School of Public Health.

300 BIOLOGICAL THREATS AND TERRORISM SPEAKERS KENNETH ALIBEK, M.D., Ph.D., Sc.D., is President of Hadron Advanced Biosystems, and corporate vice president of its publicly held parent company, Hadron. Dr. Alibek also holds the position of Distinguished Professor at George Mason University. He leads medical and scientific research programs dedicated to developing new forms of medical protection against biological weapons and other infectious diseases. Dr. Alibek served as first deputy chief of the civilian branch of the Soviet Union’s offensive biological weapons program and has more than 20 years of experience in development, management, and supervision of high containment (BL-4) pathogen laboratories. He has extensive knowledge of biotechnology, including large-scale bioprocessing and production of biological weapons; antibacterial and antiviral drug development; development of regimens for urgent prophylaxis and treatment of the diseases caused by biological weap- ons; and mass casualty handling. He is a former Soviet Army colonel. Dr. Alibek has published more than 80 articles in classified journals on the development of new types of biological weapons and on medical aspects of biodefense. Dr. Alibek defected to the United States from the Soviet Union in 1992 and subse- quently served as a consultant to numerous U.S. government agencies in the areas of industrial technology, medical microbiology, biological weapons defense, and biological weapons nonproliferation. He has worked with the National Institutes of Health, testified extensively before the U.S. Congress on nonproliferation of biological weapons and is the author of Biohazard, published by Random House. Dr. Alibek holds an M.D. in epidemiology and infectious diseases, a Ph.D. in medical microbiology, and an Sc.D. in industrial biotechnology. STEPHEN S. ARNON, M.D., is the co-discoverer of infant botulism who in 1976 founded the State of California’s research program into this and patho- physiologically related diseases that is now known as the Infant Botulism Treatment and Prevention Program. For the past 13 years he has led the Califor- nia effort to develop the first specific treatment for infant botulism, the orphan drug known as botulism immune globulin intravenous (human), for which he is one of the volunteer donors of hyperimmune source plasma. Dr. Arnon trained in internal medicine at the University of Colorado Hospitals in Denver, after which he joined the Epidemic Intelligence Service of the Centers for Disease Control and Prevention (CDC) and served in the Enteric Disease Branch. During medical school and residency he did medical work and mountaineering in Af- ghanistan, India, and Nepal. Dr. Arnon received his undergraduate, public health, and medical degrees from Harvard University and in 1989 was elected directly to fellowship in the Infectious Diseases Society of America. MICHAEL S. ASCHER, M.D., FACP, graduated from Dartmouth and Har- vard medical schools and trained in internal medicine, infectious disease, and

APPENDIX L: BIOGRAPHIES 301 immunology at Bellevue Hospital Center in New York City. He served in the U.S. Army as chief of medicine and in the Bacteriology Division at the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) and as a traveling fellow at the Royal College of Surgeons of the United Kingdom. After working with the Division of Infectious Disease at the U.C. Irvine College of Medicine, he was a public health medical officer in the Viral and Rickettsial Disease Laboratory of the California Department of Health Services and was appointed chief of the laboratory in 1995. He is a lecturer in the School of Public Health/U.C. Berkeley and a colonel in the U.S. Army Reserve as well as com- mander of the 1488th Medical Team in Oakland. He chaired the Disease Control Subcommittee of the Armed Forces Epidemiological Board and served on an interagency advisory panel on Biological Warfare Preparedness for the 21st Century. He has 28 years of biological defense experience and currently consults to the Department of Defense, Department of Health and Human Services, the Centers for Disease Control and Prevention, Mitre Corporation, the National Domestic Preparedness Office of the FBI, the Association of Public Health Laboratories, the Nuclear Threat Initiative, the National Research Council, and the Lawrence Livermore National Laboratory. He is a founding member of the Working Group on Civilian Biodefense of the Center for Civilian Biodefense Studies of the Johns Hopkins Bloomberg School of Public Health. He is a mem- ber of the bioterrorism subcommittee of the Emerging Infections Committee of the Infectious Diseases Society of America and the Infectious Disease Commit- tee of the Association of Public Health Laboratories. He is a founding member of the board of Epi-X, the electronic epidemiology information exchange of the CDC. He is the lead medical officer for biological defense activities in the Cali- fornia Department of Health Services and Principal Investigator of the CDC cooperative agreement to the state for preparedness and response to bioter- rorism. Dr. Ascher’s research interests include mechanisms of protective immu- nogenicity of microbial vaccines, advanced methods for diagnosis of infectious diseases, and fundamental issues of HIV pathogenesis. He is a member of nu- merous scientific societies and has over 90 publications. RONALD M. ATLAS, Ph.D., is currently a professor of biology, dean of the graduate school, and Co-Director of the Center for the Deterrence of Biowarfare and Bioterrorism at the University of Louisville. He is president-elect of the American Society for Microbiology and co-chair of the ASM task force on bio- logical weapons. Dr. Atlas’ recent studies have focused on the application of molecular techniques to environmental problems. His studies have included the development of “suicide vectors” for the containment of genetically engineered microorganisms and the use of gene probes and the polymerase chain reaction for environmental monitoring, including the detection of pathogens in water, soil, and air. He received a B.S. degree from the State University of New York at Stony Brook in 1968, an M.S. from Rutgers University in 1970, and a Ph.D.

302 BIOLOGICAL THREATS AND TERRORISM from Rutgers University in 1972. After one year as a National Research Council Research Associate at the Jet Propulsion Laboratory he joined the faculty of the University of Louisville in 1973. He is a member of the American Academy of Microbiology and was the recipient of the American Society for Microbiology award in Applied and Environmental Sciences. RUTH L. BERKELMAN, M.D., is currently with the Rollins School of Public Health, Emory University. An Assistant Surgeon General, she has served as a Senior Adviser to the Director, Centers for Disease Control and Prevention (CDC) and is a member of the Board of Trustees of Princeton University. She was formerly the deputy director of the National Center for Infectious Diseases and led CDC’s efforts to respond to the threat of emerging infectious diseases. Board-certified in pediatrics and internal medicine, she also serves on the American Society of Microbiology’s Committee on Public Health and is a member of the American Epidemiological Society and a fellow of the Infectious Diseases Society of America. She has extensive experience in disease surveil- lance and is a member of the Institute of Medicine Committee to Review the DoD Global Emerging Infectious Surveillance and Response System (DoD) Strategic Plan. DONALD S. BURKE, M.D., is professor of international health and epidemi- ology and Director of the Center for Immunization Research at the Johns Hop- kins Bloomberg School of Public Health. Previously, he served 23 years at the Walter Reed Army Institute of Research, including six years at the Armed Forces Research Institute of Medical Sciences in Bangkok. His research focuses on the epidemiology and prevention of human epidemic virus diseases including HIV/AIDS, dengue, flavivirus encephalitis, and hepatitis. He is past president of the American Society of Tropical Medicine. He has served on the NRC Round- table for the Development of Drugs and Vaccines Against AIDS, and the NRC Committee on Climate, Ecology, Infectious Diseases, and Human Health (as chairman), and is currently a member of the IOM Committee to Review the De- partment of Defense Global Emerging Infections Surveillance and Response System and the IOM Committee on Emerging Microbial Threats to Health in the 21st Century. R. JOHN COLLIER, Ph.D., is currently Maude and Lillian Presley Professor of Microbiology and Molecular Genetics at the Harvard Medical School where he has been since 1984. His career has been devoted to understanding at a molecular level how bacterial toxins cause the symptoms of disease. After graduating from Rice University summa cum laude, he earned his doctorate in biology from Har- vard University. He completed post-doctoral studies at the Molecular Biology Institute in Geneva. Subsequently, he was professor of microbiology at the Uni- versity of California, Los Angeles. At Harvard Medical School, he has held the

APPENDIX L: BIOGRAPHIES 303 positions of Faculty Dean for Graduate Education and Chairman of the Division of Medical Sciences. In recent years, he has served on the Advisory Panel for Defense Advanced Research Projects Agency (DARPA) Biological Warfare De- fense Unconventional Pathogen Countermeasures. Dr. Collier has been a consult- ant to Cetus Corporation, Virus Research Institute, AVANT Immunotherapeutics and is co-founder of PharmAthene, Inc. Dr. Collier was initiated as a member of the National Academy of Sciences in 1991 which awarded him the Selman A. Waksman Award in Microbiology in 1999. In addition, he is a fellow at the American Academy of Arts and Sciences and the American Academy of Micro- biology and a member of the Norwegian Academy of Science and Letters. One of his research articles was chosen for inclusion in Microbiology, a Centenary Per- spective, a compilation of one hundred landmark research articles in microbiol- ogy over the past century. Dr. Collier has authored nearly 200 publications, was associate editor of Protein Science for several years and has served on the edito- rial boards of several scientific journals. DAVID T. DENNIS, M.D., M.P.H., is currently Chief of the Bacterial Zoonoses Branch at the Division of Vector-Borne Infectious Diseases at the Centers for Disease Control and Prevention (CDC). He graduated from Whit- man College and attended the Cornell University Medical College followed by training in internal medicine at San Francisco General Hospital and Tulane Charity Hospital and in infectious diseases at New York Hospital-Cornell Medi- cal Center. Dr. Dennis received his master’s of public health from Harvard Uni- versity and was a resident in preventive medicine and Epidemic Intelligence Service officer at CDC. Prior positions include that of research medical officer in Ethiopia and Indonesia for the U.S. Naval Medical Research Detachment as well as team leader for the Regional Center for Research and Training in Tropi- cal Diseases, Malaysia. Dr. Dennis has served as medical epidemiologist to the Pennsylvania Department of Health and the New Hampshire Division of Public Health Services, where he was also Chief of the Bureau of Disease Control. His international activities also include consultancies in Mongolia, Kosovo, China, India, Vietnam, Saudi Arabia, Bahrain, United Arab Emirates, Brazil, Sudan, Nicaragua, and South Africa (Zululand). His scientific interests include research into the epidemiology and control of communicable diseases as well as the ecol- ogy of vector-borne infectious diseases. Dr. Dennis has authored or co-authored nearly 160 scientific publications. ERIC EISENSTADT, Ph.D., joined the Defense Advanced Research Projects Agency (DARPA) as a program manager in 1999. He is an active program officer for the Office of Naval Research and also serves as a Navy representative to the Joint Service Technical Panel for Chemical and Biological Warfare Defense. Prior to government service, Dr. Eisenstadt was on the faculty of the Harvard University School of Public Health in the Department of Microbiology and the

304 BIOLOGICAL THREATS AND TERRORISM Laboratory of Toxicology. Dr. Eisenstadt earned his bachelor’s degree and doc- torate in biology from Washington University in St. Louis. Following his gradu- ate studies, he completed a one-year NSF-NATO Postdoctoral Fellowship at the Université de Paris, Orsay, and a two-year Deutsche Forschungsgemeinschaft Postdoctoral Fellowship at the Universität zu Köln. Dr. Eisenstadt was also a NIH Staff Fellow at the Laboratory of Molecular Biology, NINDS. In addition to authoring and co-authoring numerous journal articles, books, and monographs, Dr. Eisenstadt is a member of the American Association for the Advancement of Science and the American Society for Microbiology. COLONEL EDWARD M. EITZEN, Jr., M.D., M.P.H., is currently Com- mander at the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID). He graduated from Auburn University as a ROTC Distinguished Military Graduate and with honors from the University of Alabama School of Medicine in Birmingham. After completing training in pediatrics at Fitzsimons Army Medical Center, he became chief of pediatrics at the 121st Evacuation Hospital in Seoul, Korea. Since then, he has taught residents at Brooke Army Medical Center and Madigan Army Medical Center, completed an M.P.H. de- gree at the University of Washington in Seattle, and completed a preventive medicine residency at Madigan Army Medical Center. He served in Operation Desert Storm as the DCCS and Surgeon of the 62nd Medical Group, 18th Air- borne Corps, before coming to USAMRIID. Before taking command of USAMRIID, Colonel Eitzen served as chief of operational medicine, a division he established at USAMRIID in 1991. Colonel Eitzen is board-certified in pedi- atrics, emergency medicine, and preventive medicine, and is subspecialty board- certified in pediatric emergency medicine and in tropical medicine and traveler’s health. Colonel Eitzen holds the Bronze Star Medal for his service in the Gulf War, the Meritorious Service Medal with four oak leaf clusters, the Army Commendation Medal, and the Army Achievement Medal. He is a member of the Order of Military Medical Merit and a recipient of the Army’s “A” Profi- ciency Designator in Pediatrics. Colonel Eitzen has served on several commit- tees for both the American Academy of Pediatrics and the American College of Emergency Physicians and has appeared as a speaker and consultant at numer- ous conferences. He has published extensively on the medical effects of biologi- cal agents and the medical management of biological casualties. He also main- tains clinical appointments in pediatrics, emergency medicine, and preventive medicine at Walter Reed Army Medical Center. Colonel Eitzen holds a dual appointment as Adjunct Associate Clinical Professor of Pediatrics and Emer- gency Medicine at the Uniformed Services University of Health Sciences. In 1998 he was selected as one of ten finalists for the Frank Brown Berry Prize in Federal Medicine awarded by U.S. Medicine.

APPENDIX L: BIOGRAPHIES 305 ANTHONY S. FAUCI, M.D., received his medical degree from Cornell Uni- versity Medical College and subsequently completed an internship and resi- dency at the New York Hospital-Cornell Medical Center. Dr. Fauci came to the NIH as a clinical associate in the Laboratory of Clinical Investigation (LCI) at NIAID. Dr. Fauci became Head of the Clinical Physiology Section, LCI, and in 1980, he was appointed Chief of the Laboratory of Immunoregulation, a position he still holds. Dr. Fauci became Director of NIAID in 1984. Dr. Fauci has made many contributions to clinical research on the pathogenesis and treatment of immune-mediated and infectious diseases. He has pioneered the field of human immunoregulation by making observations that serve as the basis for current understanding of the regulation of the human immune response. Dr. Fauci is widely recognized for delineating the precise mechanisms whereby immunosup- pressive agents modulate the human immune response. He has developed effec- tive therapies for several formerly fatal diseases. Dr. Fauci has contributed to the understanding of how the AIDS virus destroys the body’s defenses leading to its susceptibility to deadly infections. He has also delineated the mechanisms of induction of HIV expression by endogenous cytokines. Furthermore, he has been instrumental in developing strategies for the therapy and immune recon- stitution of patients with this serious disease as well as for a vaccine to prevent HIV infection. He continues to devote much of his research time to identifying the nature of the immunopathogenic mechanisms of HIV infection and the scope of the body’s immune responses to the AIDS retrovirus. Dr. Fauci has served as visiting professor at major medical centers nationwide. He is the recipient of numerous prestigious awards for his scientific accomplishments, including 22 honorary doctorate degrees. Dr. Fauci is a member of the National Academy of Sciences, the American Philosophical Society, the Institute of Medicine (Coun- cil Member), the American Academy of Arts and Sciences, and the Royal Dan- ish Academy of Science and Letters, as well as a number of other professional societies. He serves on the editorial boards of many scientific journals; as an editor of Harrison’s Principles of Internal Medicine; and as author, co-author, or editor of more than 1,000 scientific publications. ARTHUR M. FRIEDLANDER, M.D., is currently Senior Military Scientist at the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID). He received his medical degree from the University of Pittsburgh after graduat- ing from Harvard College. After completing his medical training at SUNY in Brooklyn, and a postdoctoral fellowship at the National Cancer Institute, Dr. Friedlander was a NIH Postdoctoral Research Fellow in Infectious Diseases at the University of California School of Medicine in San Diego where he subse- quently became Assistant Professor. He then joined USAMRIID as a Principal Research Investigator, and in the following years was Chief of Airborne Dis- eases Division; Chief of Department of Pathobiology, Pathology Division; and Chief of the Bacteriology Division. He is currently Adjunct Professor of Medi-

306 BIOLOGICAL THREATS AND TERRORISM cine, Uniformed Services University of the Health Sciences as well as Chairman of the Human Scientific Review Committee at USAMRIID. Dr. Friedlander’s research interests are in the pathogenesis of infectious diseases and more re- cently in vaccine development. He has patents filed for both the development of an attenuated strain of Bacillus anthracis for production of a recombinant an- thrax vaccine and an improved recombinant F1-V fusion protein vaccine against plague. He is a fellow of the Infectious Diseases Society of America and has served as a member of their Committee on Emerging Infections and Bio- Defense. Dr. Friedlander has authored or co-authored nearly 70 articles and 13 book chapters on anthrax and other biological agents. WILLIAM FRIST, M.D., has been a U.S. Senator from Tennessee since 1994 and is the first practicing physician elected to the Senate since 1928. After graduating from Princeton University, he earned his medical degree with honors from Harvard Medical School and spent the next several years in surgical train- ing at Massachusetts General Hospital; Southampton General Hospital, South- ampton, England; and Stanford University Medical Center. He is board-certified in both general surgery and heart surgery. Senator Frist taught at Vanderbilt University Medical Center where he founded and subsequently directed the multidisciplinary Vanderbilt Transplant Center, which under his leadership be- came an internationally renowned center of multi-organ transplantation. In addi- tion to performing 200 heart and lung transplant procedures, he has written more than 100 articles on medical research and three books: Transplant, which ex- amines the social and ethical issues of transplantation and organ donation; Grand Rounds in Transplantation, which he co-authored with J. H. Helderman, and Tennessee Senators, 1911–2001: Portraits of Leadership in a Century of Change, which he wrote with Lee J. Annis. In the Senate, Senator Frist serves on the Budget; Foreign Relations; and Health, Education, Labor and Pensions committees, and chairs both the Subcommittee on Public Health and Safety and the Subcommittee on African Affairs. In 1999, he was named a Deputy Whip of the Senate; in 2000 he was tapped to head the National Republican Senatorial Committee; and in 2001 he was named one of two congressional representatives to the United Nations General Assembly. U.S. Senate Liaison to the George W. Bush for President Committee, Senator Frist is now the Senate’s Liaison to the White House. JULIE L. GERBERDING, M.D., M.P.H., is the Acting Director, National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), an associate clinical professor of medicine (infectious diseases) at Emory University, and an associate professor of medicine (infectious diseases) and epidemiology and biostatistics at the University of California, San Francisco (UCSF). She earned her B.A. degree magna cum laude in chemistry and biology and M.D. degree at Case Western Reserve University and then completed her

APPENDIX L: BIOGRAPHIES 307 internship and residency in internal medicine at UCSF, where she also served as chief medical resident before completing her fellowship in clinical pharmacol- ogy and infectious diseases at UCSF. She earned her M.P.H. at the University of California, Berkeley in 1990. Dr. Gerberding is a member of Phi Beta Kappa, Alpha Omega Alpha, the American Society for Clinical Investigation (ASCI), and the American College of Physicians, and is a fellow in the Infectious Dis- eases Society of America (IDSA). She has served as chair and co-chair of the IDSA’s Committee on Professional Development and Diversity and co-chair of the Annual Program Committee, and was elected to serve as a member of the nominations committee. Dr. Gerberding is also a member of the Society for Healthcare Epidemiology of America and has served as a member of the AIDS/Tuberculosis Committee and as Academic Counselor on the SHEA Board, and will be president of SHEA in 2003. In the past, she served as a member of NCID/CDC Board of Scientific Counselors, the CDC HIV Advisory Committee, and the Scientific Program Committee, National Conference on Human Retroviruses. She has also been a consultant to NIH, AMA, CDC, OSHA, the National AIDS Commission, Office of Technology Assessment, and WHO. Her editorial activities have included appointments to the Editorial Board, Annals of Internal Medicine; Associate Editor, American Journal of Medicine, and service as a peer-reviewer for numerous journals. She has authored/co-authored more than 120 publications. Her scientific interests en- compass infection prevention/healthcare quality promotion among patients and their healthcare providers and emerging infectious diseases threats. Currently, she is actively engaged in CDC’s response to the recent bioterrorist anthrax at- tacks through the U. S. mail delivery system. JAMES J. GIBSON, M.D., M.P.H., is State Epidemiologist and Director of the Bureau of Disease Control of the South Carolina Department of Health and En- vironmental Control. In that job he is responsible for communicable and other acute disease surveillance, epidemiology, and control programs including plan- ning, management, and evaluation of HIV, STD, TB, and vaccine-preventable disease control programs. In his prior career he represented the Centers for Dis- ease Control at the U.S. Agency for International Development as medical offi- cer for child survival programs, and as a tenured associate professor of preven- tive and internal medicine at the University of South Carolina School of Medicine. He has published on the epidemiology of herpes simplex infection, syphilis, and other infectious diseases, as well as complications of therapeutic abortions. His training included service in the Epidemic Intelligence Service of the Centers for Disease Control and Prevention, and a fellowship in infectious diseases. He is board-certified in internal medicine and in preventive medicine. MARY J. R. GILCHRIST, Ph.D., was named the director of the University Hygienic Laboratory on July 1, 1995. She holds a bachelor’s degree in microbi-

308 BIOLOGICAL THREATS AND TERRORISM ology from the University of Iowa and an M.S. and Ph.D. in microbiology from the University of Illinois at Champaign-Urbana. She is a Diplomate of the American Board of Medical Microbiology. After a fellowship in clinical and public health microbiology at the Mayo Clinic, Dr. Gilchrist served in the state public health laboratories of Minnesota and Iowa and in two hospitals in Ohio. She was Director of Clinical Microbiology at the Children’s Hospital Medical Center and at the Veteran’s Affairs Medical Center in Cincinnati and Associate Professor at the University of Cincinnati. In 1991, after the Persian Gulf War, she was nominated as Federal Employee of the Year for her contributions to the bioterrorism response and planning for the Department of Veterans Affairs. In 1994, Dr. Gilchrist was named the Eagleson Institute Lecturer of the American Biological Safety Association. Dr. Gilchrist is an active member of the Ameri- can Society for Microbiology and currently serves as president of the Associa- tion of Public Health Laboratories. She is a member of the CDC’s National Center for Infectious Diseases, Board of Scientific Counselors. Dr. Gilchrist is very active in the public health response to bioterrorism on the local, state, and national levels and has several committee appointments related to bioterrorism. She has recently been appointed to the Secretary of Health and Human Services’ Advisory Council on Public Health Preparedness. DONALD A. HENDERSON, M.D., currently is director of the newly created Office of Public Health Preparedness, which coordinates national response to public health emergencies. Dr. Henderson directed the World Health Organiza- tion’s global smallpox eradication campaign and was instrumental in 1974 in initiating WHO’s global program of immunization, which is now vaccinating 80 percent of the world’s children against six major diseases and has a goal of eradicating of poliomyelitis. Dr. Henderson is a Johns Hopkins University Dis- tinguished Service Professor with appointments in the departments of Epidemi- ology and International Health at the Bloomberg School of Public Health. For the past four years, he has directed the Johns Hopkins Center for Civilian Biode- fense Studies, of which he is a founding director. The center was established to increase awareness of the medical and public health threats posed by biological weapons. From 1977 through August 1990, Dr. Henderson was dean of the Johns Hopkins School of Public Health. He rejoined the Hopkins faculty in June 1995 after five years of federal government service in which he served initially as Associate Director, Office of Science and Technology Policy, Executive Of- fice of the President and later as Deputy Assistant Secretary and Senior Science Advisor in the Department of Health and Human Services. Dr. Henderson has been recognized for his work by many institutions and governments. In 1986, he received the National Medal of Science, presented by the President of the United States. He is the recipient of the National Academy of Sciences’ highest award, the Public Welfare Medal, and, with two colleagues, he shared the Japan Prize. Most recently he received from the Royal Society of Medicine the Edward Jen-

APPENDIX L: BIOGRAPHIES 309 ner Medal. In all, 13 universities have conferred honorary degrees and 14 coun- tries have honored him with awards and decorations. PETER B. JAHRLING, Ph.D., is Principal Scientific Advisor at the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID) based in Fort Detrick, Maryland, where he advises the Commander of USAMRIID on the development and coordination of research programs directed at prevention, treatment, and surveillance of infectious disease threats. He also conducts re- search to evaluate countermeasures, especially vaccines, against viral infectious disease and biological warfare threats. Dr. Jahrling is a consultant to the World Health Organization (WHO), the Department of Health and Human Services, and the National Research Council. He is also head of the WHO Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research at USAMRIID. Since 1996, Dr. Jahrling has served as a consultant to the National Academy of Sciences/Institute of Medicine’s Russian/U.S. Collaborative Pro- gram for Research and Monitoring of Pathogens of Global Importance. He has authored more than 140 scientific papers and chapters on viruses, biological warfare agents, and vaccines. Dr. Jahrling received his A.B. in biology from Cornell University and his Ph.D. in microbiology from Cornell University Graduate School of Medical Sciences. ANNA JOHNSON-WINEGAR, Ph.D., is the Deputy Assistant to the Secre- tary of Defense, Chemical and Biological Matters (DATSD(CBM)). She serves as the single focal point within OSD responsible for oversight, coordination, and integration of the chemical/biological defense, counterproliferation support, chemical demilitarization, and Assembled Chemical Weapons Assessment (ACWA) programs. She is a member of the OSD Steering Committee for Chemical-Biological Defense, and represents the DoD on numerous interagency and international groups addressing CB issues. Before joining the Pentagon staff, Dr. Johnson-Winegar was head of the Human Systems Department at the Office of Naval Research (ONR), where she was responsible for the direction, program planning, management, and oversight of their programs in biomedical, cognitive and neural sciences, human factors, and training technologies. Prior to that, she served as Director of Environmental and Life Sciences in the Office of the Director of Defense Research and Engineering (DDR&E) and Director of Medical, Chemical, and Biological Defense Research Programs at the United States Army Medical Research and Materiel Command at Fort Detrick, Mary- land. Her previous positions included product manager at the U. S. Army Medi- cal Materiel Development Activity, and research investigator at the U. S. Army Medical Research Institute of Infectious Diseases. She also participated as a biological weapons inspector in Iraq for UNSCOM. Dr. Johnson-Winegar re- ceived a B.A. in biology from Hood College, as well as an M.S. and Ph.D in microbiology from Catholic University of America. She has published numerous

310 BIOLOGICAL THREATS AND TERRORISM technical manuscripts, and authored/co-authored several book chapters. She is a long-standing member of many professional societies, serves as a member of the National Board of Directors of the American Cancer Society (ACS), and is President of the ACS Mid-Atlantic Division. In 1998, she received the lifetime achievement award from Women in Science and Engineering. KRISTI L. KOENIG, M.D., FACEP, a board-certified emergency physician and Director of Emergency Management Strategic Healthcare Group, serves as the principal advisor on emergency management and disaster medicine to the Office of the Under Secretary for Health, Veterans Health Administration, De- partment of Veterans Affairs. Prior to joining the department, she served as the Director of Prehospital and Disaster Medicine at Alameda County Medical Center in Oakland, California, and was associate professor on the Emergency Medicine Faculty at the University of California at San Francisco. She was in- vited on sabbatical to be the Co-Director of the Accident and Emergency De- partment at St. George’s Hospital National Health Service Trust in London, England where she concurrently served as the Director of Undergraduate Medi- cal Student Education and Honorary Senior Lecturer at the University of Lon- don. Dr. Koenig has held appointments on multiple committees and boards in- cluding the Joint Commission on Accreditation of Healthcare Organizations’ (JCAHO) Committee on Healthcare Safety, chair of the Society for Academic Emergency Medicine Disaster Medicine Task Force, the American College of Emergency Physicians liaison to the Federal Emergency Management Agency, the National Association of EMS Physicians Standards and Practice Committee, a California Senate appointment as the California Medical Association repre- sentative to the State Emergency Medical Services Commission, the California Health Policy and Data Advisory Commission, Advance Directive Subcommit- tee, the California Association of Hospitals and Health Systems EMS/Trauma Committee, and the London Ambulance Service Accreditation Ambulance Standards Working Group. Dr. Koenig is an honors graduate in applied mathe- matics from the University of California at San Diego, received her medical degree from Mount Sinai School of Medicine in New York, and completed an emergency medicine residency at Highland Hospital in Oakland, California, serving as chief resident in her final year. She is a fellow of the American Col- lege of Emergency Physicians and a clinical professor of emergency medicine at the George Washington University School of Medicine and Health Sciences. Dr. Koenig has also been an associate editor for Academic Emergency Medicine and serves on the editorial board for Journal Watch Emergency Medicine. She has authored numerous articles on emergency and disaster management. SCOTT P. LAYNE, M.D., Ph.D., is a tenured associate professor of epidemi- ology at the UCLA School of Public Health. He is board-certified in internal medicine and infectious diseases and trained in applied physics. Before joining

APPENDIX L: BIOGRAPHIES 311 UCLA, Dr. Layne was a staff member at the Los Alamos and Lawrence Livermore national laboratories. There, his work in infectious diseases utilized mathematical models and epidemiological data to understand the spread of HIV/AIDS in the United States. His further work in virology utilized mathe- matical models and laboratory experiments to understand the kinetics of HIV infection and biological blocking activities of immunoglobulins against HIV. In 1999, Dr. Layne organized a meeting under the auspices of the Institute of Medicine and National Academy of Engineering to discuss infectious disease threats such as influenza, multidrug-resistant tuberculosis, and HIV and consider new approaches against them. What emerged was a plan to create new kinds of high-throughput laboratory and database resources that expedite disease sur- veillance and intervention efforts on an international scale. Dr. Layne is cur- rently organizing a new effort to build a global lab against influenza in collabo- ration with the World Health Organization Influenza Program. He also is proposing a plan to build a high-throughput automated lab and database against bioweapons agents to strengthen homeland security and facilitate compliance and verification procedures for the Biological Weapons Convention. Dr. Layne has authored many publications and is editor of the book, Firepower in the Lab: Automation in the Fight Against Infectious Diseases and Bioterrorism. SCOTT R. LILLIBRIDGE, M.D., is Special Assistant to the Secretary of Health and Human Services for National Security and Emergency Management. Dr. Lillibridge works with HHS Secretary Tommy G. Thompson to enhance national preparedness for bioterrorism and other health emergencies. These ef- forts have included support to the various departmental initiatives in response to the recent anthrax crimes following the September 11 attacks. Until July 2001, Dr. Lillibridge was the first director of the CDC Bioterrorism Preparedness and Response Program. This program was charged with enhancing CDC’s capacities to assist states and other partners in responding to bioterrorism. In addition to infectious disease concerns, the CDC program included consideration of chemi- cal terrorism, the development of a National Pharmaceutical Stockpile, and sup- port for a National Laboratory Response Network for bioterrorism. The CDC’s program was initiated in 1999. Dr. Lillibridge’s career has focused on emer- gency public health issues. He was the lead physician during the initial U.S. Public Health Service (PHS) response to the Oklahoma City bombing and also led the U.S. medical delegation to Tokyo following the Sarin release in 1995. During the 1996 Olympics, he served as the PHS science advisor to the multi- agency task force that was assembled to protect the public against biological and chemical terrorism. From 1990–1992, Dr. Lillibridge was a member of CDC’s Epidemic Intelligence Service (EIS). JAMES D. MARKS, M.D., Ph.D., currently is Professor of Anesthesia and Pharmaceutical Chemistry at the University of California, San Francisco. Dr.

312 BIOLOGICAL THREATS AND TERRORISM Marks received his undergraduate training at UC Berkeley, majoring in Bio- chemistry, and received his M.D. from UCSF. He completed residencies in in- ternal medicine and anesthesia and a fellowship in critical care medicine. He is board-certified in all three specialties. He was a graduate student at the Medical Research Council Laboratory of Molecular Biology under the supervision of Dr. Greg Winter and received his Ph.D. in 1992 for a dissertation titled, Making Human Antibody Fragments in Bacteria and Bacteriophage. From 1996–2001 he was the medical director of the Medical-Surgical Intensive Care Unit at San Francisco General Hospital and continues to be an attending physician in the intensive care unit and operating rooms at San Francisco General Hospital. Dr Marks is a world recognized pioneer in the field of antibody engineering. He directs a research group using antibody diversity libraries and molecular evolu- tion to dissect the molecular basis of infectious diseases and cancer and develop novel antibody based therapeutic approaches for these diseases. For the last 8 years he has worked on understanding the requirements for potent antibody neutralization of the botulinum neurotoxins under funding from the Department of Defense. He has 86 relevant publications in the field and is a co-inventor on 7 issued patents and 6 patent applications. ANDREA MEYERHOFF, M.D., M.Sc., DTMH, is the Director, Anti- terrorism Programs, U.S. Food and Drug Administration (FDA). FDA anti- terrorism activities refer to the agency’s dual missions in public health and law enforcement. These include the protection of regulated products from terrorist tampering, and the availability of safe and effective medical products. FDA anti- terrorism preparedness and response planning to meet these public health needs is developed and coordinated by the director, who serves as the point of contact for anti-terrorism issues at FDA. Dr. Meyerhoff joined the FDA in 1996 as a medical officer in the Division of Special Pathogens, and assumed her present position in July 2001. She is board-certified in infectious disease and internal medicine, and holds a M.Sc. in clinical tropical medicine. She is a Clinical As- sistant Professor of Medicine at Georgetown University. THOMAS L. MILNE, is the executive director of the National Association of City and County Health Officials (NACCHO), a position he has held since January 1998. NACCHO serves the 3,000 local health departments in the coun- try, providing a broad range of membership services, national policy advocacy, and cutting-edge tools and services for local public health practitioners. Mr. Milne reports to a thirty-member board of health officials who are elected by their member peers. He is a member of several national committees and boards addressing such issues as workforce development, bioterrorism, public health infrastructure, academics, and leadership, and was recently appointed to the HHS secretary’s Advisory Council on Public Health Preparedness. Prior to his current position, Mr. Milne served for 15 years as the executive director of the

APPENDIX L: BIOGRAPHIES 313 Southwest Washington Health District, a three county public health department in Washington State. While there, he conceived and helped lead a dynamic healthy community process that has received national attention. Mr. Milne was a member of the steering committee that developed the innovative Public Health Improvement Plan in the state, and served on a variety of state and local boards relating to HIV/AIDS, managed care, and higher education. He has also served on a number of national boards, including those for NACCHO, the American Public Health Association, and the Public Health Leadership Society. Mr. Milne was a scholar in the inaugural year of the Public Health Leadership Institute. GARY J. NABEL, M.D., Ph.D., is currently Director of the Vaccine Research Center at the National Institutes of Health. He came from the University of Michigan in Ann Arbor, where he was the Henry Sewall Professor of Internal Medicine and professor of biological chemistry, as well as a Howard Hughes Medical Institute investigator. Dr. Nabel graduated magna cum laude from Har- vard College, and then earned his M.D. and Ph.D. from Harvard University. He completed his postdoctoral fellowship in the laboratory of David Baltimore at the Whitehead Institute, MIT. Dr. Nabel is well known as a molecular virologist and immunologist for his work in the fields of HIV, cancer, and Ebola virus research. Dr. Nabel’s laboratory has studied mechanisms by which cells coordi- nate in the regulation of the expression of genes during viral infection and de- velopment. Specifically, they have examined the molecular basis of HIV tran- scriptional activation. In late 1997, Dr. Nabel led a group of researchers who demonstrated in guinea pigs that a DNA-based vaccine could generate protective immune responses to Ebola virus. He and his colleagues were also the first to use direct gene transfer to introduce therapeutic proteins into patients with melanoma, showing the feasibility and safety of this approach. Dr. Nabel is a member of the Institute of Medicine and his honors include the James Tolbert Shipley Prize for Research for Harvard Medical School, the Midwest American Federation for Clinical Research Young Investigator Award, and the ASBMB- Amgen Scientific Achievement Award. Dr. Nabel currently is associate editor of the Journal of Virology and the Journal of Clinical Investigation and serves on the editorial boards of several other journals. C.J. PETERS, M.D., is a professor in the Department of Microbiology, Immu- nology and Pathology at the University of Texas Medical Branch in Galveston. Dr. Peters has recently been named director of the Center for Biodefense at UTMB, which will serve as a catalyst for research and development efforts on effective medical countermeasures against bioterrorism and biological warfare. He had been Chief of Special Pathogens at the Centers for Disease Control and Prevention in Atlanta. Formerly chief of the Disease Assessment Division at USAMRIID, he has worked in the field of infectious diseases for three decades with the CDC, the U.S. Army, and the U.S. Public Health Service. He was the

314 BIOLOGICAL THREATS AND TERRORISM head of the unit that contained the outbreak of Ebola virus at Reston, Virginia. He was also called in to contain an outbreak of deadly hemorrhagic fever in Bo- livia. He received his M.D. from Johns Hopkins University and has more than 275 publications in the area of virology and viral immunology. Dr. Peters is cur- rently a member of the National Research Council Committee on Occupational Health and Safety in Care of Nonhuman Primates and the Institute of Medicine Committee on Emerging Microbial Threats to Health in the 21st Century. STANLEY PLOTKIN, M.D., is currently a medical and scientific consultant, Aventis Pasteur, after seven years as Medical and Scientific Director, Pasteur Merieux Connaught Vaccines, Paris. He is also Emeritus Professor of Pediatrics at the University of Pennsylvania and Emeritus Professor of Virology at the Wistar Institute. Over the course of his career he has served as Senior Assistant Surgeon, Epidemic Intelligence Service, USPHS, director of the Division of Infectious Diseases at Children’s Hospital of Philadelphia, and as associate chairman, Department of Pediatrics, University of Pennsylvania. Dr. Plotkin has developed many vaccines, including the Rubella vaccine, RA27/3 strain, now exclusively used in the United States and throughout the world. He has held editorial positions with many scholarly journals and is a member of numerous professional and scientific societies, including the American Academy for the Advancement of Science, the Society for Pediatric Research, the American So- ciety for Microbiology, the Infectious Diseases Society of America, and the American Epidemiologic Society. Dr. Plotkin has received several professional awards including the French Legion Medal of Honor (1998); the Clinical Virol- ogy Award, Pan American Group for Rapid Viral Diagnosis (1995); the Distin- guished Physician Award, Pediatric Infectious Disease Society (1993); and the Bruce Medal of the American College of Physicians. DAVID A. RELMAN, M.D., is associate professor of medicine (infectious diseases) and of microbiology and immunology at Stanford University, and Acting Chief of Infectious Diseases at the Veterans Affairs Palo Alto Health Care System. Dr. Relman received his clinical training at Harvard Medical School and Massachusetts General Hospital, and his postdoctoral research training at Stanford. He joined the Stanford faculty in 1992. Since then, his re- search activities have focused on the molecular mechanisms of bacterial patho- genesis, and on the discovery of previously unrecognized microbial pathogens and commensals. He has described a number of novel disease-causing infectious agents for the first time, and expanded our understanding of human microbial ecology. Recent work includes efforts to employ human and microbial genomic approaches for detection and classification of infectious diseases. Dr. Relman serves on advisory panels for federal agencies, such as the departments of De- fense and Energy, CDC, and NIH, and committees for professional societies,

APPENDIX L: BIOGRAPHIES 315 such as the Infectious Diseases Society of America and the American Society for Microbiology. PHILIP K. RUSSELL, M.D., received his bachelor’s degree from Johns Hop- kins University and his medical degree from the University of Rochester. He is board-certified in internal medicine and has authored or co-authored over 100 publications on infectious diseases. He is a professor emeritus at Johns Hopkins School of Hygiene and Public Health. Prior to joining the university in 1990, Dr. Russell served in the U.S. Army Medical Department where he pursued a career in infectious disease research, retiring as a major general. Military assignments included Director, Walter Reed Army Institute of Research; Commander, Fitzsimons Army Medical Center; and Commander, U.S. Army Medical Re- search and Development Command. Overseas tours included Pakistan, Thailand, and Vietnam. His military awards include the Legion of Merit and the Distin- guished Service Medal. Academic appointments included professor of preven- tive Medicine at the Uniformed Services University of the Health Sciences. Dr. Russell is a past president of the American Society of Tropical Medicine and Hygiene, and a fellow of the Infectious Disease Society of America. He served as special adviser to the international Children’s Vaccine Initiative. He was a member of the Board of Scientific Counselors of the National Center for Infec- tious Diseases and served on the President’s Advisory Committee on Human Radiation Experiments. He has served on numerous boards and advisory com- mittees for national and international agencies and now serves on the boards of directors of the International AIDS Vaccine Initiative and the Albert B. Sabin Vaccine Institute. He is member of the Strategic Advisory Committee of the Bill and Melinda Gates Children’s Vaccine Program. and a consultant to the Bill and Melinda Gates Foundation. He chairs the Malaria Vaccine Task Force of the National Institute of Allergy and Infectious Diseases. He currently serves as special adviser in the Office of Public Health Preparedness, Department of Health and Human Services. JOHN SIMPSON, M.B.B.S., M.F.P.H.M., received his medical degree from University College, London. He trained as a general practitioner and was a prin- cipal in general practice in Croydon, London. He then trained in public health and was a consultant in communicable disease control in Surrey (where he set up the countywide service), and Wiltshire, England. These posts entailed considerable involvement in emergency planning and response. Since October 2000 he has been Regional Epidemiologist, Communicable Disease Surveillance Centre, South East, covering a population of 8 million in southern England. As part of this post he has recently coordinated a major study of the health effects of the flooding in Lewes, Sussex, England, in October/November 2000. He was sec- onded part-time to be head of the Emergency Planning Co-Ordination Unit at the Department of Health in London and subsequent to this has been working at the

316 BIOLOGICAL THREATS AND TERRORISM Department of Health since September as part of the team coordinating the U.K. Health Response to the September 11 and deliberate anthrax release incidents in the United States. He is also a senior research fellow at the University of Bath. KATHRYN E. STEIN, Ph.D., is the Director of the Division of Monoclonal Antibodies (DMA), Office of Therapeutics Research and Review, Center for Biologics Evaluation and Research (CBER), FDA, and Acting Chief, Laboratory of Molecular and Developmental Immunology (LMDI), DMA. Dr. Stein re- ceived her B.A. in chemistry from Bard College and her Ph.D. in microbiology and immunology from Albert Einstein College of Medicine. She received a Na- tional Research Service Award from the National Institutes of Health (NIH) for post-doctoral studies at Harvard with Dr. Harvey Cantor and at the NIH with Dr. William Paul prior to her joining CBER’s Division of Bacterial Products in 1980. She has been the director of DMA since 1992 and prior to that time was chief of the LMDI in the Division of Bacterial Products, Office of Vaccines Re- search and Review. She has an active research laboratory at CBER and is an expert in the field of immune responses to polysaccharide antigens, including the polysaccharide capsules of human pathogens. LIEUTENANT COMMANDER DONALD C. WETTER, P.A.-C, M.P.H., is an Emergency Coordinator with the Office of Emergency Preparedness in the U.S. Public Health Service. He has been involved in emergency services since 1968, primarily emergency medicine hospital, prehospital, and urgent care. He has had experience in disaster response since 1995. Mr. Wetter received his bachelor’s in microbiology from Arizona State University and his physician assistant degree from the University of Alabama in Birmingham. He has a mas- ter’s of public health degree from the University of Washington. KEVIN YESKEY, M.D., an active duty 0-6 in the U.S. Public Health Service, is the director of the Bioterrorism Preparedness and Response Program, National Center for Infectious Diseases, Centers for Disease Control and Prevention. He has served as the deputy director, Emergency Public Health in the Division of Emergency and Environmental Health Services, National Center for Environ- mental Health, CDC. Dr. Yeskey is board-certified in emergency medicine. His previous assignments include associate professor and vice chair, Department of Military and Emergency Medicine, Uniformed Services University School of Medicine, and chief medical officer, PHS Office of Emergency Preparedness. His disaster response experience includes deployments to hurricanes, earth- quakes, floods, mass migrations, and terrorist bombings.

APPENDIX L: BIOGRAPHIES 317 FORUM STAFF STACEY L. KNOBLER, is Director of the Forum on Emerging Infections at the Institute of Medicine (IOM). She previously served as the co-director of the IOM Board on Global Health’s study, Neurological, Psychiatric, and Develop- mental Disorders in Developing Countries, and research associate for the As- sessment of Future Scientific Needs for Live Variola Virus. Ms. Knobler is ac- tively involved in program research and development for the Board on Global Health. Previously, she has held positions as a Research Associate at the Brookings Institution, Foreign Policy Studies Program and as an Arms Control and Democratization Consultant for the Organization for Security and Coopera- tion in Europe in Vienna and Bosnia-Herzegovina. Ms. Knobler has also worked as a research and negotiations analyst in Israel and Palestine. She is currently a member of the CBACI Senior Working Group for Health, Security, and U.S. Global Leadership. Ms. Knobler has conducted research and co-authored pub- lished articles on biological and nuclear weapons control, foreign aid, health in developing countries, poverty and public assistance, and the Arab-Israeli peace process. MARJAN NAJAFI, M.P.H., is a research associate for the Forum on Emerging Infections in the Board on Global Health. She has also worked with the IOM committee that produced Veterans and Agent Orange: Update 2000. She re- ceived her undergraduate degrees in chemical engineering and applied mathe- matics from the University of Rhode Island. Ms. Najafi served as a public health engineer with the Maryland Department of Environment and, later, the Research Triangle Institute. After obtaining a master’s of public health from the Bloom- berg School of Public Health at Johns Hopkins University, she managed a lead poisoning prevention program in Micronesia with a grant from the U.S. Depart- ment of Health and Human Services. Prior to joining IOM, she worked on a study researching the effects of cellular phone radiation on human health. LAURIE A. SPINELLI is a project assistant for the Forum on Emerging In- fections in the Board on Global Health. Ms. Spinelli joined the IOM in July 2000 and has worked with the IOM committee that generated the Neurological, Psychiatric, and Developmental Disorders: Meeting the Challenge in the Devel- oping World report. Currently, she is working on two forthcoming reports: Re- ducing the Impact of Birth Defects in Developing Countries and Improving Birth Outcomes in Developing Countries. Prior to joining IOM, she graduated from Syracuse University with a bachelor of arts degree in speech communications. Ms. Spinelli also teaches an interpersonal communication course at the College of Southern Maryland.

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In the wake of September 11th and recent anthrax events, our nation's bioterrorism response capability has become an imminent priority for policymakers, researchers, public health officials, academia, and the private sector. In a three-day workshop, convened by the Institute of Medicine's Forum on Emerging Infections, experts from each of these communities came together to identify, clarify, and prioritize the next steps that need to be taken in order to prepare and strengthen bioterrorism response capabilities. From the discussions, it became clear that of utmost urgency is the need to cast the issue of a response in an appropriate framework in order to attract the attention of Congress and the public in order to garner sufficient and sustainable support for such initiatives. No matter how the issue is cast, numerous workshop participants agreed that there are many gaps in the public health infrastructure and countermeasure capabilities that must be prioritized and addressed in order to assure a rapid and effective response to another bioterrorist attack.

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