TABLE 6 Biological Mechanisms for the Possible Role of Immunizations in Increasing the Risk of Immune Dysfunction

Adverse Health Outcome

Mechanism

Committee Conclusion About the Weight of the Biological Evidence

Autoimmune disease

Molecular mimicry

Theoretical only

 

Bystander effect

Weak

Loss of protection induced by homologous infection

Theoretical only

Via the hygiene hypothesis

Theoretical only

Collective mechanistic possibilities

Weak

Allergic disease

Bystander effect

Weak

 

Via the hygiene hypothesis

Theoretical only

 

Collective mechanistic possibilities

Weak

Heterologous Infections

Carrier-induced epitope suppression

Strong

 

Competition for antigen presentation

 



The National Academies | 500 Fifth St. N.W. | Washington, D.C. 20001
Copyright © National Academy of Sciences. All rights reserved.
Terms of Use and Privacy Statement