DeStefano et al. (2001)

Case- control

252 children from 4 HMOs that participate in Vaccine Safety Datalink project of the CDC along with their 768 matched controls (United States)

From chart review: vaccine exposure prior to diabetes incidence date: DTaP, DTwP, measles-mumps-rubella, varicella; Hib, HepB;

Timing of Hep B (never vaccinated; birth to 4 days, 15 to 55 days, and GTE 56 days); Hib schedule (3 doses in first 8 mos + 4^th dose at 12–18 mos vs. 1 dose at 21–27 months)

Cases in HMO registries with ICD-9 diagnosis of type 1 diabetes

Adjusted OR (95% CI):

Vaccines and Type I diabetes

Varicella = 1.02 (0.61- 1.71)

Hep B timing and risk of type 1 diabetes

Hib schedule and risk of type 1 diabetes:

Limited ability in comparing Hib schedules since only a few children received no Hib or only 1 dose at 21–27 months

Weak evidence relevant to causality. Favors no effect of specific vaccine or the timing of Hepatitis B and Hib.

EURODIAB Study Group (2000)

Case- control

900 cases with diabetes and 2302 controls matched on age

Vaccination history by interview or questionnaire; Vaccines included BCG, polio,

Diabetes cases from a population-based register

Adjusted OR (95% CI)

Ascertainment bias

Weak evidence relevant to causality;

Favors no effect