Appendix B
Workshop Agenda

CANCER AND THE ENVIRONMENT: GENE–ENVIRONMENT INTERACTIONS

Sponsored by

The Roundtable on Environmental Health Sciences, Research, and Medicine

———————

National Academy of Sciences Auditorium.

2101 Constitution Avenue, N.W., Washington, D.C.

May 16–17, 2001

Wednesday, May 16, 2001

8:40 a.m.

Remarks from the IOM President

Kenneth Shine, M.D.

8:55 a.m.

Remarks and Charge to Participants

Samuel Wilson, M.D.

Deputy Director, NIEHS

9:10 a.m.

Statement of Workshop Objectives

Franklin Mirer, Ph.D. (Workshop Co-chair)

9:20 a.m.

Cancer, the Environment, and the Media

Mr. Samuel Donaldson (ABC News)



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Cancer and the Environment: Gene-Enviroment Interaction Appendix B Workshop Agenda CANCER AND THE ENVIRONMENT: GENE–ENVIRONMENT INTERACTIONS Sponsored by The Roundtable on Environmental Health Sciences, Research, and Medicine ——————— National Academy of Sciences Auditorium. 2101 Constitution Avenue, N.W., Washington, D.C. May 16–17, 2001 Wednesday, May 16, 2001 8:40 a.m. Remarks from the IOM President Kenneth Shine, M.D. 8:55 a.m. Remarks and Charge to Participants Samuel Wilson, M.D. Deputy Director, NIEHS 9:10 a.m. Statement of Workshop Objectives Franklin Mirer, Ph.D. (Workshop Co-chair) 9:20 a.m. Cancer, the Environment, and the Media Mr. Samuel Donaldson (ABC News)

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Cancer and the Environment: Gene-Enviroment Interaction SESSION I: LINK BETWEEN ENVIRONMENTAL FACTORS AND THE DEVELOPMENT OF CANCER Moderator: Woodie Kessel, M.D., M.P.H. 9:50 a.m. Genes and the Environment in Cancer Etiology Joseph Fraumeni, Jr., M.D. (NCI) 10:30 a.m. Diet and Other Environmental Factors as Modifiers of Cancer Risk John Milner, Ph.D. (Pennsylvania State University and NCI) 11:10 a.m. Break 11:25 a.m. Genetic Epidemiology as a Tool for Gene–Environment Interactions Kari Hemminki, M.D., Ph.D. (Karolinska Institute) 12:05 a.m. The p53 Pathway: At the Crossroads of Molecular Carcinogenesis and Molecular Epidemiology Curtis C. Harris, M.D. (NCI) 12:45 p.m. General Discussion 1:00 p.m. Lunch SESSION II: GENETIC–ENVIRONMENTAL INTERACTION IN SPECIAL POPULATIONS Moderator: Lovell A. Jones, Ph.D. Vulnerable Populations 1:45 p.m. Health Disparities: Do Gene–Environment Interactions Play a Role? Lovell A. Jones, Ph.D. (M.D. Anderson Cancer Center) 2:05 p.m. Cancer Disparities in Appalachia Gilbert Friedell, M.D. (Markey Cancer Center) 2:20 p.m. Migrant Farmworkers’ Children and Pesticides: A High-Risk Population María A. Hernández-Valero, Dr.P.H. (M.D. Anderson Cancer Center)

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Cancer and the Environment: Gene-Enviroment Interaction 2:35 p.m. Priorities and Special Populations: Ties That Bind Armin Weinberg, Ph.D. (Baylor College of Medicine) 2:50 p.m. General Discussion 3:05 p.m. Break Cancer in Children 3:20 p.m. Childhood Cancer and Diet: Preliminary Evidence Greta Bunin, Ph.D. (Children’s Hospital of Philadelphia) 3:35 p.m. Trends: Incidents and Survivorship Leslie Robison, Ph.D. (University of Minnesota) 3:50 p.m. Chemicals and Chromosomes, Children and Cancer, Clusters and Cohorts in a New Century Richard Jackson, M.D., M.P.H. (CDC) 4:10 p.m. General Discussion Women and Cancer 4:25 p.m. Epidemiology and Genetic Susceptibility to Breast Cancer Brian Henderson, M.D. (University of Southern California, Keck School of Medicine) 4:40 p.m. Gene-Environment Risk Factors for Breast Cancer Mary Wolff, Ph.D. (Derald H. Ruttenberg Cancer Center, Mount Sinai School of Medicine) 4:55 p.m. Breast Cancer Genetics: BRCA1 and BRCA2 Genes Olufunmilayo Olopade, M.D. (The University of Chicago, Pritzker School of Medicine) 5:10 p.m. General Discussion 5:30 p.m. Reception Thursday, May 17, 2001 8:30 a.m. Welcome Back The Honorable Paul G. Rogers, Roundtable Chair Special Address

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Cancer and the Environment: Gene-Enviroment Interaction 8:35 a.m. Cancer Treatment Based on Immune Stimulation Steven Rosenberg, M.D., Ph.D. (NCI) SESSION III: GENETIC–ENVIRONMENTAL INTERACTION IN SPECIFIC CANCERS Moderator: John Minna, M.D. Lung Cancer 9:30 a.m. Molecular Pathogenesis of Lung Cancer John Minna, M.D. (University of Texas Southwestern Medical Center) 9:50 a.m. Genetic Susceptibility to Lung Cancer Margaret Spitz, M.D., M.P.H. (M.D. Anderson Cancer Center) 10:10 a.m. General Discussion 10:30 a.m. Break Colon Cancer 10:50 a.m. Environmental and Genetic Factors Involved in Colorectal Carcinogenesis Raymond DuBois, M.D., Ph.D. (Vanderbilt University—Ingram Cancer Center) 11:10 a.m. Environmental Issues Related to Colon Cancer David Alberts, M.D. (Arizona Cancer Center) 11:30 a.m. General Discussion Prostate Cancer 11:50 a.m. Similarities of Prostate and Breast Cancer: Evolution, Diet, and Estrogens Donald Coffey, Ph.D. (Johns Hopkins University) 12:10 a.m. The Effect of Herbal Therapies in Prostate Cancer Robert S. DiPaola, M.D. (Cancer Institute of New Jersey) 12:30 p.m. General Discussion

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Cancer and the Environment: Gene-Enviroment Interaction 12:50 p.m. Lunch SESSION IV: MOVING FORWARD Moderator: Samuel Wilson, M.D. 1:30 p.m. Introduction and Remarks The Honorable Paul G. Rogers, J.D. 2:00 p.m. Cancer and the Environment: A View from “the Hill” The Honorable John E. Porter, J.D. Roundtable Summation and General Discussion 2:30 p.m. Summation of the Workshop Lovell A. Jones, Ph.D. Roundtable Member 2:45 p.m. Roundtable Discussion Discussion of the workshop and future needs of cancer research   Ms. Susan Braun President and CEO Susan G. Komen Breast Cancer Foundation   Donald Coffey, Ph.D. Johns Hopkins University   Ms. Linda Frame, R.N., M.S., ACON Senior Clinical Advisor Susan G. Komen Breast Cancer Foundation   Lovell A. Jones, Ph.D. Professor, Gynecologic Oncology M.D. Anderson Cancer Center   Martha Linet, M.D., M.P.H. National Cancer Institute   David Ringer, Ph.D., M.P.H. Scientific Program Director American Cancer Society 4:00 p.m. Adjournment