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OCR for page 98
Appendix C
Chronology of Important Events Regarding
Vaccine Safety
Year
Vaccine
Licensure
Legislation and/or
Policy Statements
IOM Reports on
Vaccine Safety
1955
1963
Inactivated
poliomyelitis
vaccine (IPV) available
Oral poliomyelitis
vaccine (OPV)
available, replaces IPV
Measles vaccine available
1967 Mumps vaccine available
1969
Rubella vaccine available
197 1 Measles-Mumps-Rubella
(MMR) vaccine available
1977
1979 Current formulation of
rubella vaccine available,
replaces earlier versions
1982
Plasma-derived hepatitis B
vaccine available
Mumps vaccination
recommended
98
Evaluation of
Poliomyelitis Vaccines
OCR for page 99
APPENDIX C
99
Vaccine
Year Licensure
Legislation and/or
Policy Statements
IOM Reports on
Vaccine Safety
1985 Hib vaccine licensed for
children >15 months
1986
1988
1990
Congress passes Public
Law 99-660, the National
Childhood Vaccine
Injury Act (introduced
in 1984) calls for:
· est. of NVPO
· est. of NVAC
· est. of VICP
· est. of ACCV
IOM review of 1)
pertussis and rubella,
2) routine child vaccines
2 Hib conjugate vaccines
licensed for use beginning
at 2 months
Evaluation of Poliomyelitis
Vaccine Policy Options
1991 Acellular pertussis Hepatitis B Adverse Effects of Pertussis
component licensed for the recommended by ACIP and Rubella Vaccines
4th and 5th doses of the for addition to
5-part DTP series in
ACEL-IMUNE
childhood immunization
schedule
ACIP recommends Hib
be added to childhood
immunization schedule
1992 Acellular pertussis Hepatitis B vaccine:
component licensed for the Added universal
4th and 5th doses of the vaccination for all
5-part DTP series in infants, high-risk
Tripedia adolescents (e.g., IV
drug users, persons with
multiple sex partners)
1993 Combined DTP and Hib
vaccine (Tetramune)
licensed
OCR for page 100
100
IMMUNIZATION SAFETY REVIEW
Vaccine
Year Licensure
Legislation and/or
Policy Statements
IOM Reports on
Vaccine Safety
1994
1995 Varicella virus vaccine
available (Varivax)
1996
DTaP vaccine licensed for
first three doses given in
infancy (Tripedia and
ACEL-IMUNE were
ACIP recommends
using IPV for the first
2 polio vaccinations,
followed by OPV for
previously licensed for only remaining doses.
the 4th and 5th doses). Intended to be a
transitional schedule for
3-5 years until an
all-IPV series is available
ACIP recommends
children 12months-
12 years receive
Varicella vaccine
1997 Additional DTaP vaccine ACIP recommends
(Infanrix) licensed for first DTaP in place of DTP
4 doses of 5-part series
1998 Additional DTaP vaccine
(Certiva) licensed for first
4 doses of 5-part series
1999
Adverse Events Associated
with Childhood Vaccines:
Evidence Bearing on
Causality
DPT and Chronic Nervous
System Dysfunction: A
New Analysis
Options for Poliomyelitis
Vaccinations in the United
States: Workshop Summary
Vaccine Safety Forum:
Summary of Two
Workshops
Risk Communication and
Vaccination: Workshop
Summary
ACIP updates MMR
recommendation,
encouraging use of the
combined MMR vaccine
ACIP updates varicella
vaccine recommendation,
. . . r
requiring Immunity for
child care and school entry
OCR for page 101
APPENDIX C
10
Vaccine
Year Licensure
Legislation and/or
Policy Statements
IOM Reports on
Vaccine Safety
ACIP recommends an
all-IPV schedule begin
January 2000 to prevent
cases of vaccine-associated
paralytic polio
AAP and PHS recommend
removal of thimerosal
r
Irom vaccines
Also recommended
postponement of hepatitis
B vaccine from birth to
2-6 months for infants
of hepatitis B surface
antigen-negative mothers
Additional supply of
thimerosal-free hepatitis
B vaccine made available
2000
2001
MMWR notifies readers
of the availability of a
thimerosal-free hepatitis
B vaccine, enabling the
resumption of the birth
dose
Pneumococcal vaccine
for infants and young
children licensed (Prevnar)
ACIP recommends
pneumococcal
vaccination for all
children 2-23 months,
and at-risk children
24-59 months (e.g.,
immunocompromised)
October: ACIP drafts
statement expressing a
preference for use of
thimerosal-free DTaP,
Hib, and Hep B vaccines
by March 2002
Immunization Safety
Review: Measles-Mumps-
Rubella Vaccine and
Autism
Immunization Safety
Review: Thimerosal-
Containing Vaccines and
Neuro-developmental
Disorders
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102
IMMUNIZATION SAFETY REVIEW
Vaccine
Year Licensure
Legislation and/or
Policy Statements
TOM Reports on
Vaccine Safety
2002
Immunization Safety
Review: Multiple
Immunizations and Immune
Dysfunction
Immunization Safety
Review: Hepatitis B
Vaccine and Demyelinating
Neurological Disorders
Immunization Safety
Review: SV40
Contamination of Polio
Vaccine and Cancer
Representative terms from entire chapter:
vaccine safety