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OCR for page 244
Appendix B Issues of Resistance: Microbes, Vectors, and the Host February 6–7, 2002 Lecture Room National Academy of Sciences 2101 Constitution Avenue, NW Washington, DC 20418 AGENDA WEDNESDAY, FEBRUARY 6, 2002 **** A PUBLIC DISSEMINATION PANEL DISCUSSION OF THE BIOLOGICAL THREATS REPORT will take place from 9:00–10:00 am. Breakfast will be served. **** 10:30 am Welcome and Opening Remarks Adel Mahmoud, Chair, Forum on Emerging Infections President, Merck Vaccines 10:45 Arms Races with Evolving Diseases: Patterns, Costs and Containment Stephen Palumbi, Harvard University Session I: Case Studies of Antimicrobial Resistance Moderator: Carlos Lopez, Eli Lilly 11:15 The Cost of Antimicrobial Resistance Richard Smith, University of East Anglia, United Kingdom 11:45 Resistant Strains of Pneumococci, Staphylococci, and Enterococci Alexander Tomasz, Laboratory of Microbiology, Rockefeller University 12:15 pm LUNCH

OCR for page 244
1:30 Resistance to HIV-1 Drug Therapies Robert Redfield, The Institute of Human Virology, University of Maryland 2:00 Chloroquine-Resistant Malaria Thomas Wellems, National Institute for Allergy and Infectious Diseases, NIH 2:30 Schistosomiasis and Antihelminth Resistance Charles King, Division of Geographic Medicine, Case Western Reserve University 3:00 Epitope Escape Variants Robert Webster, St. Jude Children’s Research Hospital and World Health Organization Collaborating Center for Studies on the Ecology of Influenza in Animals and Birds Session II: Vector Resistance Moderator: Barry Beaty, Colorado State University 3:30 Pesticide Resistance: Implications for Disease Emergence and Control Janet Hemingway, Liverpool School of Tropical Medicine, United Kingdom 4:00 Studies in Antibiotic Resistance and Insecticide Resistance: Commonalties, Differences, and New Directions Steven Peck, Zoology Department, Brigham Young University 4:30 Managing the Emergence of Pesticide Resistance in Disease Vectors William Brogdon, Division of Parasitic Diseases, Centers for Disease Control and Prevention Session III: Discussion Panel Moderator: Carole Heilman, National Institute for Allergy and Infectious Diseases 5:00 William Jack, Georgetown University Lynn Marks, GlaxoSmith Kline Steve Brickner, Pfizer 6:00 Adjournment of the first day 6:15 DINNER MEETING OF THE FORUM ON EMERGING INFECTIONS

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THURSDAY, FEBRUARY 7, 2002 8:30 am Continental Breakfast 9:00 Opening Remarks / Summary of Day 1 Stanley Lemon, Vice Chair, Forum on Emerging Infections Dean of Medicine, The University of Texas Medical Branch, Galveston 9:15 Antibiotic Resistance 1992–2002: A Decade’s Journey Stuart Levy, School of Medicine, Tufts University Session IV: Factors of Emergence Moderator: Mary Wilson, Harvard University 9:45 Patterns of Use for Antimicrobials in Developing Countries Iruka Okeke, University of Bradford, United Kingdom 10:15 Health Care-Acquired Infections: Hospitals and Long-Term Care Facilities as Breeding Grounds for Antimicrobial Resistance Lindsay Nicolle, University of Manitoba, Canada 10:45 The Use of Antimicrobials in Food-Producing Animals Thomas Shryock, Elanco Lilly Research 11:15 Special Considerations: Anthrax, Large-Scale/Long-Term Prophylaxis or Therapy and the Emergence of Microbial Resistance Thomas Elliott, Armed Forces Radiobiology Research Institute, Uniformed Services University of the Health Sciences Session V: Containing the Development of Resistance Moderator: James Hughes, Centers for Disease Control and Prevention 11:45 Emergence of Multiple Mechanisms of Resistance to Antibacterials Shahriar Mobashery, Department of Biochemistry, Wayne State University 12:15 pm Emerging Technologies to Combat Resistance: Opportunities and Limitations Vincent Fischetti, Laboratory of Bacterial Pathogenesis, Rockefeller University 12:45 LUNCH

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1:30 Interagency Action Plan to Combat Antimicrobial Resistance David Bell, National Center for Infectious Diseases, Centers for Disease Control and Prevention Murray Lumpkin, Office of the Commissioner, Food and Drug Administration 2:15 Using Pharmacokinetics and Pharmacodynamics to Manage Resistance in the Hospital, at the Bedside, and in Drug Development Jerome Schentag, University at Buffalo School of Pharmacy 2:45 FDA Regulatory Approaches to Controlling Antimicrobial Resistance Mark Goldberger, Center for Drug Evaluation and Research, Food and Drug Administration 3:15 CDC’s 12-Step Program to Address Antimicrobial Resistance Julie Gerberding, National Center for Infectious Diseases, Centers for Disease Control and Prevention 3:45 The Challenges to Implementing Global Policy for the Control of Antimicrobial Resistance Anthony Savelli and Terry Green, Management Sciences for Health 4:15 BREAK Session VI: Priorities for the Next Steps in Addressing Resistance Moderator: Fredrick Sparling, University of North Carolina, Chapel Hill 4:30 With the backdrop of the previous days’ presentations and discussion, Forum members, panel discussants, and the audience will comment on the issues and next steps that they would identify as priority areas for consideration within industry, academia, public health organizations, and other government sectors. The discussion of priorities will summarize the issues surrounding emerging opportunities for more effective collaboration as well as the remaining research and programmatic needs. The confounding issues of the major obstacles to preparing an optimal response, particularly as it relates to the complexities of interaction between private industry, research and public health agencies, regulatory agencies, policymakers, academic researchers, and the public will be explored with an eye toward innovative responses to such challenges.

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Panel Discussants:   Ramanan Laxminarayan, Resources for the Future Mary Torrence, U.S. Department of Agriculture, Cooperative State Research Education and Extension Service Donald Roberts, Uniformed Services University of the Health Sciences 5:30 Adjourn