TABLE 6-1 Animal Welfare Considerations Associated with Disease Modelsa

Type of Disease

Potential Problems

Interventions

Occupational Health Issues

Degenerative (Parkinson’s disease, Alzheimer’s disease, frontotemporal dementia)

Adipsia, aphagia, tremor, incoordination, disorientation

Nursing care

MPTP

Trauma (head and spinal cord injury, peripheral nerve repair and regeneration)

Paralysis, distress, self-mutilation, seizures

Nursing care, local anesthetics, analgesia, sedatives, antibiotics, anti-convulsants

 

Infectious disease (HIV, prions, meningitis, encephalitis)

Seizures, debility, paralysis, disorientation

Monitoring, antibiotics, anti-convulsants

Microbial pathogens

Brain and spinal cord tumors

Pain, paralysis, disorientation, seizures

Analgesia, nursing care, anti-convulsants

Human cell lines

Stroke

Surgery complications, paralysis, disorientation, visual deficits

Monitoring, nursing care

 

Seizures (genetic, audiogenic, drug- or lesion-induced)

Kindling, status epilepticus, secondary injury

Monitoring, anti-convulsants

Noise exposure (free field)

Immune-mediated (multiple sclerosis, myasthenia gravis, polymyositis)

Muscle weakness, paralysis

Nursing care

 

Secondary medical conditions (diabetic neuropathy, renal or hepatic encephalopathy)

Self-mutilation, disorientation

Nursing care

 

Pain (peripheral nerve damage, tissue damage, central nervous system damage)

Self-mutilation, guarding, changes in locomotor activity, aggression

Local anesthetics, analgesics, sedatives, environmental management

 

Psychiatric diseases (depression, schizophrenia)

Learned helplessness, social withdrawal

Monitoring, environmental enrichment

 

a These lists are intended to be representative, not all-inclusive.



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