animal in New England, rabies is relatively low on my differential list. However, certainly in other places in the world, rabies may be much more problematic. Then I think there should be a risk assessment study performed to determine whether that vaccine might be worthwhile to use. A variety of vaccines that have been used in nonhuman primates; however, the efficacy is unknown. I do not think anyone has done studies to show that they are efficacious.

DR. ROBERTS: The second question is for all of the pathologists on the panel. In this session, we have talked about diseases and about the importance of record keeping and allocation of resources. What do you do in terms of banking tissue samples; how long do you keep them? It is a tremendous information database, but it also takes up a lot of space and requires a lot of inventory. Is there any feedback you would like to give on your policies?

DR. BASKIN (Gary Baskin, Tulane National Primate Research Center): We keep blots and slides forever. We keep wet tissues until the case is signed out. On routine animals, animals that are on specific projects, we ask the investigator whether to store the wet tissues after the pathology work is complete. Our problem is storage capacity. We perform approximately 900 micropsies per year. You can imagine the storage problems with those kinds of samples, and we do not keep them.

DR. MANSFIELD: We have a smaller colony and probably do about 300 to 350 micropsies per year. We keep all paraffin-embedded, wet, and frozen tissue, at least as far back as 1988. All animals’ micropsy have both formal and fixed and frozen tissue on them, but it is becoming a space issue for us also.

DR. MOTZEL: We keep all blots and slides, but we routinely dispose of wet tissues after a period of a few years.

PARTICPANT F: I have been working with John Robertson at the Regional College of Veterinary Medicine at Virginia Tech to begin developing a tissue archive for primates. Hopefully it would be possible to develop a repository there, in a relatively low cost area, where additional slides, tissues, and specimens could be stored for any of you. Those of you who have just mentioned some of the problems with repositories eventually will probably be filled. This project is pursuant to our development of a great ape brain bank, which is now being expanded into a CNS tissue repository beyond great apes. I mention it because it has already been very productive, particularly in alliance with some of the human brain banks that are supported under the Alzheimer’s program.



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