Table 2.7 Risk Groups for Iodine-Induced Hyperthyroidism

Underlying thyroid disease

  • Iodine supplementation for endemic iodine-deficiency goiter

  • Iodine administration to patients with euthyroid Graves disease, especially those in remission after antithyroid drug therapy

  • Nontoxic nodular goiter

  • Autonomous nodules

  • Nontoxic diffuse goiter

No underlying thyroid disease

  • Iodine administration to patients with no recognized underlying thyroid disease, especially in areas of mild to moderate iodine deficiency

Iodine may also be useful in some clinical situations other than a need to prevent iodine deficiency (Table 2.8).

Table 2.8 Medical Uses of Stable Iodine


  • Treatment and prevention of iodine deficiency goiter

  • Thyroid storm

  • Preoperative preparation of toxic goiter

  • Post 131I therapy of Graves disease

  • As sole therapy of Graves disease (when sensitive to antithyroid drugs)

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