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TABLE 5-4 Clinical Trials on the Effects of Potassium Supplements on Blood Pressure in Nonhypertensive Individuals in Order of Increasing Duration of Intervention

Reference

Subjects

Study Design

Potassium Intake,b g/d (mmol/d)

Barden et al., 1991a

37 women

4-d crossover

Placebo

3.1 (80) KCl supplement

Gallen et al., 1998

10 men, 11 women

9-d crossover; K restriction; 4.1 g (180 mmol) Na

0.78 (20) diet plus placebo

3.1 (80) KCl supplement

Krishna et al., 1989a

10 men

10-d crossover; 2.8–4.6 (120–200 mmol) Na

0.4 (10) diet plus placebo

3.5 (90) [80 KCl supplement]

Skrabal et al., 1981a

20 men

2-wk crossover

3.1 (80) KCl supplement [4.6 (200) Na]

3.1 (80) KCl supplement [1.2 (50) Na]

7.8 (200) KCl supplement [4.6 (200) Na]

7.8 (200) KCl supplement [1.2 (50) Na]

Khaw and Thom, 1982a

20 men

2-wk crossover

1.6 (41) diet

2.5 (64) KCl supplement

Poulter and Sever, 1986a

19 men

2-wk crossover

Placebo

2.5 (64) KCl supplement

Mullen and O’Connor, 1990a

24 men

2-wk crossover

Placebo

2.9 (75) KCl supplement

2.9 (75) K citrate supplement

Brancati et al., 1996a

31 men, 56 women

3-wk parallel, 2.9–4.0g (127–175 mmol) Na

Placebo plus 1.3-1.4 (32-35) K from diet

3.1 (80) KCl supplement plus 1.3-1.4 (32-35) K from diet



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