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TABLE 5-5 Clinical Trials on the Effects of Potassium Supplements on Blood Pressure in Hypertensive Individuals in Order of Increasing Duration of Intervention

Reference

Subjects

Study Design

Potassium Intake,b g/d (mmol/d)

Smith et al., 1992a

12 men

9 women

4-d crossover

4.6 g (200 mmol) Na

Placebo

4.7 (120) KCl

Krishna and Kapoor, 1991

10 men

2 women

10-d parallel; K restriction

2.8 g (120 mmol) Na

3.8 (96) [80 mmol KCl supplement]

0.62 (16) diet

Zoccali et al., 1985a

10 men

9 women

2-wk crossover

Placebo

3.9 (100) KCl supplement

MacGregor et al., 1982a

12 men

11 women

4-wk crossover

Placebo

2.5 (64) KCl supplement

Richards et al., 1984a

8 men

4 women

4- to 6-wk crossover; 4.1g (180 mmol) Na

2.3 (60)

7.8 (200)

Smith et al., 1985a

11 men

9 women

4-wk crossover; 1.6 g (70 mmol) Na

Placebo

2.5 (64) KCl supplement

Valdes et al., 1991a

13 men

11 women

4-wk crossover

Placebo

2.5 (64) KCl supplement

Fotherby and Potter, 1992a

5 men

13 women

4-wk crossover

Placebo

2.3 (60) KCl supplement

Kaplan et al., 1985a

6 men

10 women

6-wk crossover

Placebo

2.3 (60) KCl supplement

Matlou et al., 1986a

32 women

6-wk crossover

Placebo

2.5 (65) KCl supplement

Grobbee et al., 1987a

34 men

6 women

6-wk crossover

Placebo

2.8 (72) KCl supplement

Svetkey et al., 1987a

75 men

26 women

8-wk parallel

Placebo

4.7 (120) KCl supplement

Patki et al., 1990a

8 men

29 women

8-wk crossover

Placebo

2.3 (60) KCl supplement



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