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Duration (days)

Feeding Study

Design

Range of Sodium g/d (mmol/d)

Potassium Level g/d (mmol/d)

Lowest

Highest

5

Yes

Dose-escalation

0.46 (20)

25.9 (1,128)

3.1 (80)

4

Yes

Crossover

0.23 (10)

9.2 (400)

2.3 (60)

3–7

Yes

Dose-escalation

0.23 (10)

34.5 (1,500)

3.1 (80)

9

No

Crossover

3.7 (16)a

5.5 (239)a

≈ 1.9 (50)b

9

No

Crossover

0.18 (8)a

5.6 (245)a

≈ 1.9 (50)b

28

Yes

Crossover

0.23 (10)

9.4 (410)

3.9 (100)

4

Yes

Crossover

1.2 (50)

8.7 (380)

3.1 (80)

14

Yes

Crossover

0.92 (40)

7.8 (340)

≈ 1.2 (30)b

4

Yes

Crossover

1.2 (50)

8.7 (380)

3.1 (80)

14

Yes

Crossover

0.46 (20)

7.4 (320)

2.7 (70)

28

No

Crossover

1.2 (50)

4.6 (200)

2.7 (70)

14

Yes

Crossover

0.92 (40)

7.8 (340)

≈ 1.2 (30)b

14

Yes

Crossover

0.92 (40)

7.8 (340)

≈ 1.2 (30)b

28

Yes

Crossover

1.5 (67)a

3.3 (144)

3.1 (79)b

28

Yes

Crossover

1.5 (64)a

3.2 (141)a

1.6 (41)b

lytes, renal function, and serum lipids of normotensive man. J Lab Clin Med 87:418–434.


Luft FC, Rankin LI, Bloch R, Weyman AE, Willis LR, Murray RH, Grim CE, Weinberger MH. 1979. Cardiovascular and humoral responses to extremes of sodium intake in normal black and white men. Circulation 60:697–706.


MacGregor GA, Markandu ND, Sagnella GA, Singer DRJ, Cappuccio FP. 1989. Double-blind study of three sodium intakes and long-term effects of sodium restriction in essential hypertension. Lancet 2:1244–1247.


Roos JC, Koomans HA, Dorhout-Mees EJ, Delawi IMK 1985. Renal sodium handling in normal humans subjected to low, normal, and extremely high sodium supplies. Am J Physiol 249:F941–F947.


Sacks FM, Svetkey LP, Vollmer WM, Appel LJ, Bray GA, Harsha D, Obarzanek E, Conlin PR, Miller ER, Simons-Morton DG, Karanja N, Lin PH. 2001. Effects of blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. N Engl J Med 344:3–10.

Sullivan JM, Ratts TE, Taylor JC, Kraus DH, Barton BR, Patrick DR, Reed SW. 1980. Hemodynamic effects of dietary sodium in man. Hypertension 2:506–514.



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