FIGURE D-14 Proposed in-market surveillance algorithm: Application by using the probiotics Generally Recognized as Safe (GRAS) Notification 000049 as a case study. An asterisk (*) along with the corresponding text underlined indicate steps that were either not apparent or not carried out within the GRAS notification 000049 provided to the committee. = a state or condition, = a decision point, = an action, sidebar = an elaboration of recommendation or statement.

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